Evaluation of adjunctive effect of daily dietary supplements with omega 3 and propolis to non-surgical periodontal therapy: Randomized Clinical Trial

Abstract

Background and Objective:This study aimed to investigate the systemic effect of dietary supplement omega 3 (ω-3) polyunsaturated fatty acids (PUFAs ) and propolis as an adjunct to non surgical periodontal therapy and evaluate the gingival crevicular fluid level of receptor activator of nuclear factor κ ligand (RANKL). Material and Methods:Forty-five subjects with stage II or III and grade B periodontitis were included in this study. They were randomly assigned into three groups: Group I: 15 subjects received scaling and root planing (SRP) only. Group II: 15 subjects received SRP combined with daily dietary supplementation of omega 3 for 6 months. Group III: 15 subjects received SRP combined with a daily dietary supplement of propolis for 6 months. Clinical parameter (plaque index, bleeding index, pocket depth, and clinical attachment level) and biochemical analysis of RANKL in GCF were recorded at baseline, 3 months and 6 months after treatments Results: Statistical analysis revealed that both (ω-3) and propolis statistically significant (P≤0.01) reduce PD and CAL at 3 and 6 months compared to its baseline and control group. RANKL level in GCF statistically significant (P≤0.01) reduced at 3 and 6 months in both treated groups compared to its baseline and control group. No statistical significant (P≥0.05) difference between both treated groups concerning clinical and biochemical parameters.Conclusion: The present study suggests that dietary supplementation with ω-3 PUFAs or propolis effective as an adjunct to nonsurgical periodontal therapy in the management of patients with periodontitis.

Effects of omega-3 supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in chronic periodontitis patients: A randomized clinical trial

“…This study assessed the effects of omega-3 fatty acid supplementation on periodontal parameters in patients with CP. The sample size of this study was similar to that in a study by Keskiner et al, [29] higher than that in studies by Martinez et al, [28] and Rampally et al, [33] and smaller than that in studies by Stańdo et al, [34] and Shalaby and Morsy [35]. The dosage of omega-3 administered in the present study was similar to some previous studies [33,36,37].…”

Use and Effectiveness of Propolis on Chronic Periodontitis: a Systematic Review

“…Each subject was randomly assigned to a study group as follows: group 1 with 15 subjects who only received SRP; group 2 with 15 subjects who received SRP accompanied by daily dietary supplementation with omega 3 for 6 months, and group 3 with 15 patients who received SRP with daily propolis supplementation for 6 months. Statistical analysis revealed that both propolis and omega 3 are significant and that they decrease periodontal disease and improve the level of clinical insertion at 6 months (45). Therefore, Shalaby et al suggest dietary supplementation with propolis or omega 3 as an adjuvant of periodontal therapy (46).…”

“…Statistical analysis revealed that both propolis and omega 3 are significant and that they decrease periodontal disease and improve the level of clinical insertion at 6 months (45). Therefore, Shalaby et al suggest dietary supplementation with propolis or omega 3 as an adjuvant of periodontal therapy (46). Sanghani et al analyzed 20 patients with a minimum of two deep periodontal pockets.…”

“…In the majority of studies, the experimental process was carried out during a period of 6 months, which is the time period stipulated, according to the scientific literature, during which there are better results after clinical treatment with adjuvants in CP (50). The presentation of the experimental agent was used locally as an irrigator (38,40,51), such as toothpaste (39), and the former was also tested as an oral systemic agent (tablets/capsules), exhibiting promising results in both patients with DM2 and in those with CP (37) and in patients without systemic alterations (45). Several authors in this review reported that the propolis extract utilized in their experiments was the hydroalcoholic extract at 20% (40,42,43), since it has been observed that this is the best method for extracting the highest amount of polyphenols, in that these compounds are those that confer antimicrobial properties on the propolis (52).…”

“…Several authors in this review reported that the propolis extract utilized in their experiments was the hydroalcoholic extract at 20% (40,42,43), since it has been observed that this is the best method for extracting the highest amount of polyphenols, in that these compounds are those that confer antimicrobial properties on the propolis (52). However, authors such as Shalaby et al and El-Sharkawy et al, who employed propolis in tablets as a vehicle, did not report what type of extract was used for its preparation (45,48). The latter is a disadvantage because it is not known whether the effect is due to the hydroalcoholic preparation or to the phenols of propolis.…”