Aim
The present study aimed to monitor the clinical outcomes and the metabolic response of periodontal therapy (non‐surgical) in patients with periodontitis (chronic) and uncontrolled diabetes (type 2).
Methods
Eighty‐eight subjects with periodontitis (chronic) and uncontrolled diabetes (type 2) were enrolled in this controlled trial and allocated randomly to the test group (44 patients were received immediate periodontal therapy) or the control group (44 patients were received delayed periodontal therapy). The metabolic and clinical evaluations were conducted at baseline and 3 months. This included clinical attachment level, glycated hemoglobin (HbA1c), bleeding on probing, visible plaque, and pocket depth. The periodontal therapy in this study consists of one‐stage scaling and root planning, a combination of systemic antibiotics (amoxicillin 500 mg and metronidazole 400 mg), and oral hygiene instructions.
Results
Regarding clinical and metabolic parameters at baseline, no statistically significant differences were displayed between the two groups. However, at 3‐month follow‐up period the patients within the test group demonstrated significantly better clinical and metabolic outcomes than patients in the control group.
Conclusion
The non‐surgical periodontal treatment using a combination of metronidazole and amoxicillin significantly improved the metabolic outcome in addition to periodontal health in diabetic subjects with chronic periodontitis.
Aim
This study aimed to provide evidence on the impact of chronic periodontitis (CP) on the severity of erectile dysfunction (ED) through the assessment of the salivary level of tumor necrosis factor‐alpha (TNF‐α).
Methods
140 patients with chronic periodontitis and erectile dysfunction were enrolled in this study and then randomly allocated to the control group (70 participants received delayed periodontal treatment) or test group (70 participants were subjected to immediate periodontal therapy). The assessment of the clinical and serological outcomes was done at baseline and 3 months postoperatively. This included pocket depth (PD), visible plaque, clinical attachment level (CAL), bleeding on probing (BOP), level of tumor necrosis factor‐alpha (TNF‐α), and the severity of erectile dysfunction. Periodontal therapy consists of oral hygiene instructions and single‐visit scaling and root planing.
Results
There were no significant differences regarding the serological and clinical outcomes at baseline between the two groups (p > .05). At 3‐month follow‐up, the PD, BOP, CAL, and visible dental plaque means in the control group were significantly higher than those in the test group (PD: 4.94 ± 0.647 mm vs. 4.25 ± 0.619 mm; BOP: 49.03 ± 29.98 vs. 6.20 ± 7.14; CAL: 4.96 ± 0.631 mm vs. 4.31 ± 0.591 mm; visible dental plaque: 48.49 ± 30.07 vs. 5.83 ± 6.51) (p = .00). Compared with baseline findings, both groups showed significant reductions in TNF‐α in serum, salivary TNF‐α, and severity of erectile dysfunction (p < .001).
Conclusion
The non‐surgical periodontal therapy could significantly improve the severity of erectile dysfunction in addition to periodontal and serological parameters. Salivary TNF‐α could be used as a new diagnostic tool to detect the severity of erectile dysfunction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.