The effect of non- surgical periodontal therapy on periostin level in the gingival crevicular fluid of type II diabetic patients with periodontitis

Abstract

Background and Objective: Periostin is a protein highly expressed within extracellular matrix of bone and periodontal ligament responsible for tissue integrity and play significant role in wound repair and bone remodeling. The present study designed to estimate the effectiveness of non surgical periodontal therapy (NSPT) on level of periostin in the gingival crevicular fluid (GCF) of diabetic patient with periodontitis. Materials and Methods: 36 subjects were admitted in this study. The subjects allocated into 3 groups, Group I involve 12 periodontally healthy subjects, Group II involve 12 participants with periodontitis. Group III: involve 12 participants with periodontitis diagnosed with diabetes mellites type II. Group II and III were received conventional periodontal treatment scaling and root planning (S&RP). Clinical parameters: pocket depth (PD), clinical attachment loss (CAL), gingival index (GI), plaque index (PI) were measured and the GCF samples were gathered for assessment of periostin at baseline and at 3 months postoperatively. Results: Periostin level in the GCF were significantly increased in healthy subjects (P≤0.001) compared to those with diabetic patients with periodontitis and patients with periodontitis only. NSPT in group II and III resulted in significant increase (P≤0.001) in periostin level at 3 months postoperatively. Conclusion: NSPT can significantly increase the level of periostin in the GCF of diabetic patients with periodontitis and those with periodontitis only. Moreover, periostin suggested to be inflammatory marker reliable for diagnosis and evaluation of the outcome of periodontal treatment.

Periostin in the relation between periodontal disease and atherosclerotic coronary artery disease: A pilot randomized clinical study

“…Periostin has been particularly proposed as a marker of susceptibility and activity of periodontal disease because it negatively correlates with the clinical parameters indicative of periodontal health 39–41 . In the presence of systemic diseases such as diabetes, levels of periostin in the GCF in cases of periodontal disease are even lower 42 . Our group made important contributions to the understanding of this association in a number of in vitro, animal, and clinical studies 15,18–21 .…”

“…[39][40][41] In the presence of systemic diseases such as diabetes, levels of periostin in the GCF in cases of periodontal disease are even lower. 42 Our group made important contributions to the understanding of this association in a number of in vitro, animal, and clinical studies. 15,[18][19][20][21] In summary, factors associated to periodontal disease, such as inflammation and bacterial byproducts, can reduce the expression of periostin by periodontal ligament fibroblasts.…”

“…So much so that, although the influence of diabetes, for example, on serum periostin levels has not been specifically analyzed in the current study, there is biological plausibility for the existence of this relationship, similar to that shown by Morsy and Ali. 42 In turn, diabetes influences cardiovascular disease by altering, among others, the normal healing capacity because of changes in the inflammatory capacities and control mechanisms. In this way, periostin could have a role in regulating both.…”

Periostin level in gingival crevicular fluid in periodontal disease: a systematic review and meta-analysis

“…In another study that was not included in our quantitative analysis, Morsey SM et al [ 28 ] examined the effect of non-surgical periodontal treatment on periosteum levels in patients with type 2 diabetes. In that study, there were 36 participants in three groups, including 12 people who were periodontally healthy, 12 periodontitis patients, and 12 participants with periodontitis and type 2 diabetes.…”