Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway promotes tumorigenesis. Natural agents, including phytochemicals, exhibit potent anticancer activities via various mechanisms. However, the therapeutic potency of phytoconstituents as inhibitors of JAK/STAT signaling against cancer has only come into focus in recent days. The current review highlights phytochemicals that can suppress the JAK/STAT pathway in order to impede cancer cell growth. Various databases, such as PubMed, ScienceDirect, Web of Science, SpringerLink, Scopus, and Google Scholar, were searched using relevant keywords. Once the authors were in agreement regarding the suitability of a study, a full-length form of the relevant article was obtained, and the information was gathered and cited. All the complete articles that were incorporated after the literature collection rejection criteria were applied were perused in-depth and material was extracted based on the importance, relevance, and advancement of the apprehending of the JAK/STAT pathway and their relation to phytochemicals. Based on the critical and comprehensive analysis of literature presented in this review, phytochemicals from diverse plant origins exert therapeutic and cancer preventive effects, at least in part, through regulation of the JAK/STAT pathway. Nevertheless, more preclinical and clinical research is necessary to completely comprehend the capability of modulating JAK/STAT signaling to achieve efficient cancer control and treatment.

Medicinal herbs are one of the imperative sources of drugs all over the world. Star anise (Illicium verum), an evergreen, medium-sized tree with star-shaped fruit, is an important herb with wide distribution throughout southwestern parts of the Asian continent. Besides its use as spice in culinary, star anise is one of the vital ingredients of the Chinese medicinal herbs and is widely known for its antiviral effects. It is also the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu ® ), an antiviral medication for influenza A and influenza B. Besides, several other molecules with numerous biological benefits including the antiviral effects have been reported from the same plant. Except the antiviral potential, star anise possesses a number of other potentials such as antioxidant, antimicrobial, antifungal, anthelmintic, insecticidal, secretolytic, antinociceptive, antiinflammatory, gastroprotective, sedative properties, expectorant and spasmolytic, and estrogenic effects. This review aimed to integrate the information on the customary attributes of the plant star anise with a specific prominence on its antiviral properties and the phytochemical constituents along with its clinical aptness. K E Y W O R D S antiviral, Illicium verum, oseltamivir, shikimic acid, star anise, Tamiflu

Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy. This review contains an extensive critical discussion on the potential of marine microbial compounds and marine microalgae metabolites as anticancer drugs, highlighting their chemical structure and exploring the underlying mechanisms of action. Current limitation, challenges, and future research pathways were also presented.

P LANT terpenoids are utilized generally for their aromatic behaviour. They act as conventional herbal remedies and are under research for antineoplastic activity, antibacterial activity, antidiabetic activity, anti-inflammatory activity, anti-platelet aggregate activity, antiviral activity, antioxidative activity, antiallergic, antihypertensive activity and additional pharmaceutical actions. Plants not only just deposit terpenes for herbariums defence yet in addition emanate essential mixtures in response to herbivory and numerous different abiotic and biotic stresses. Now a day, there is a phenomenal developing enthusiasm for natural triterpenes over the most recent couple of decades because of the revelation of their potential biological and pharmacological activities. Pentacyclic triterpenes are ancillary plant elements broadly spread in stem, leaves, bark and fruit peel. Specifically, the ursane, lupane and oleanane pentacyclic triterpenes show different pharmacological impact. Subsequently, these triterpenes are offering key components for the improvement of novel multi-targeted bioactive agents.

Background:Garlic (Allium sativum L.) has been accepted universally to be applied in food, spice and traditional medicine. The medicinal and other beneficial properties of garlic are attributed to organosulfur compounds.Objective:As of today no simultaneous analysis has been performed; hence the transformation of allicin to its degraded products during cultivation and storage is open into doubt.Materials and Methods:In our present work, we have tried to develop a sensitive and reproducible analytical method to measure allicin by high performance liquid chromatography-ultraviolet analysis with effect of post-acoustic waves and microwave radiation on fresh garlic cloves.Results:The process revealed the effect of different radiation techniques on fresh garlic retains the principle component, allicin in its pure form and generated higher yield than the conventional way of extraction.Conclusion:Therefore, materializing these techniques in the pharmaceutical industry will definitely be proved beneficial in term of time as well as money. Most interestingly, the methods ruled out possibilities of degradation of organosulfur compounds as well.

: Barleria prionitis, a small perpetual, prickly shrub, belongs to the family Acanthaceae, normally called “porcupine flower” or “Vajradanti” with a lot of vernacular names. It is an indigenous herb of Southern Asia and some regions of Africa. The therapeutic use of leaf, flower, stem, seed, shoot, root and in certain cases complete herb of B. prionitis against numerous disorders including cough, fever, jaundice, asthma, severe pain, acne, cut wound are recognized by ayurvedic and other conventional medicinal systems. An exhaustive bibliographic research of this plant has been carried out by means of scientific engines and databases like Google Scholar, PubMed, and Science direct; as a result, it has been found that this herb possesses a rich phytochemical content and a wide range of pharmacological activities such as antimicrobial activity, anthelmintic activity, antidiarrheal activity, antioxidant activity, antifertility activity, anti-diabetic activity, anti-inflammatory activity, cytoprotective activity, antiarthritic activity, diuretic activity, hepatoprotective activity, enzyme inhibitory activity and antinociceptive activity without any toxic effects. The plant has been reported to have tannin, saponin, flavonoid, glycoside, alkaloid and phenolic compounds present in it. It is also a noteworthy origin of secondary metabolites such as β-sitosterol, lupeol, syringic acid, and vanillic acid. However, having a potential therapeutic importance, it is still underutilization.

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Objective: Acne, one among the very fashionable socially distressing skin conditions created by Propionibacterium acne have generally been treated by antibiotics. Within the light of the growing threat of antibiotic resistance, natural plant products are applied as a safer alternative. Keeping the very fact in the background, during this research work, the formulation of gel from the extracts of Murraya koeinigii leaves are prepared and evaluated as an anti-acne drug. Methods: The fresh leaf extracts were subjected to phytochemical and antimicrobial screening. Minimum Inhibitory Concentration (MIC) decided. Gel formulation of the extracts was developed and evaluated. The manufactured formulations were subjected to In vitro antibacterial activity against P. acnes, S. epidermidis and S. aureus. The marker compound, clindamycin, in herbal anti-acne preparation, was kept for the comparison with the zones of inhibition for antibacterial activity. Results: Anti-acne property was explored with the help of a standard curve and by comparing diffusion profiles by taking clindamycin as a reference. Conclusion: From the present study it can be concluded that addition of permeation enhancer in the test formulation will improve the diffusion profile and thus it was designed to add permeation enhancer.