Pharmacological Property of Pentacyclic Triterpenoids

Abstract

P LANT terpenoids are utilized generally for their aromatic behaviour. They act as conventional herbal remedies and are under research for antineoplastic activity, antibacterial activity, antidiabetic activity, anti-inflammatory activity, anti-platelet aggregate activity, antiviral activity, antioxidative activity, antiallergic, antihypertensive activity and additional pharmaceutical actions. Plants not only just deposit terpenes for herbariums defence yet in addition emanate essential mixtures in response to herbivory and numerous different abiotic and biotic stresses. Now a day, there is a phenomenal developing enthusiasm for natural triterpenes over the most recent couple of decades because of the revelation of their potential biological and pharmacological activities. Pentacyclic triterpenes are ancillary plant elements broadly spread in stem, leaves, bark and fruit peel. Specifically, the ursane, lupane and oleanane pentacyclic triterpenes show different pharmacological impact. Subsequently, these triterpenes are offering key components for the improvement of novel multi-targeted bioactive agents.

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

“…It also improved the proapoptotic actions of both bortezomib and thalidomide. In another study, celastrol inhibited STAT3 phosphorylation and STAT3-mediated IL-17 expression, and T-helper 17 (Th17) differentiation and proliferation in multiple myeloma cells [186].…”

“…γ-Tocotrienol prevented the phosphorylation of molecules involved in the JAK/STAT pathway, including JAK1, JAK2, and c-Src, in human liver cancer cells [185]. It also induced the expression of SHP-1, which is one type of tyrosine phosphatase engaged in the JAK/STAT signal's negative regulation [79], in liver cancer cells in a concentration-dependent fashion [185,186].…”

Anticancer Potential of Betulonic Acid Derivatives

“…Moreover, pentacyclic triterpenes have been detected in edibles such as mango, apple peel, strawberries, pear peel, green pepper, guava, mulberry, or olives, but also in herbal plants such as rosemary, oregano, basil, and lavender. The individual natural human consumption of triterpenes is reported to be approximately 250 mg per day in the Western world and 400 mg per day in Mediterranean countries [ 42 ]. However, small quantities, estimated to be under 0.1% of the dry weight of the plant organ, are found in plants.…”

Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs

“…Nature remains a rich resource of bioactive and varied chemotypes, and while comparatively very few of the extracted natural products are developed into clinically useful drugs by themselves, these specific molecules also act as preparatory models for more efficacious analogues and prodrugs through the implementation of chemical methodology. The main priority of natural products for the identification and development of new anticarcinogenic pharmaceutical drugs and the value of cross-disciplinary collaboration in the extraction of novel molecular functionalities from natural product resources have been extensively investigated [5].…”

“…Isolated marine cyanobacteria-derivedanthracyclines, phenoxazin-3-one compounds, polyketides and peptides(1)(2)(3)(4)(5)(6)(7)(8).…”