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Microfluidic devices have shown promising applications in the bioprocessing industry. However, the lack of modularity and high cost of testing and error limit their implementation in the industry. Advances in 3D printing technologies have facilitated the conversion of microfluidic devices from research output to applicable industrial systems. Here, for the first time, we presented a 3D printed modular microfluidic system consisting of two micromixers, one spiral microfluidic separator, and one microfluidic concentrator. We showed that this system can detach and separate mesenchymal stem cells (MSCs) from microcarriers (MCs) in a short time while maintaining the cell’s viability and functionality. The system can be multiplexed and scaled up to process large volumes of the industry. Importantly, this system is a closed system with no human intervention and is promising for current good manufacturing practices. Graphical Abstract

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In article number 2005363, Majid Ebrahimi Warkiani and co‐workers comprehensively review the existing intracellular delivery technologies at the macro‐ and micro‐/nanoscale based on their impact resolution. This study gives an insight to researchers interested in intracellular delivery, ranging from biologists looking for the most appropriate cargo‐delivery method, to cell physiologists seeking a deeper understanding of intracellular delivery and its underlying mechanisms, to biomanufacturing experts eager to boost production efficiency.

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