Microfluidic Platforms for Cell Sorting

Rapid separation of bacteria from primary nasal samples using inertial microfluidics

“…22 Microfluidic-based particle separation technologies have proven to be well suited for isolating target cells from heterogeneous cell suspensions. 21,[23][24][25][26] However, most of these techniques are limited by low throughput and low separation efficiency. Also, they are often prone to clogging, hindering non-continuous operations.…”

Design and simulation of a novel integrated microfluidic chip for cell isolation and culture

“…For instance, in CTC separation, CTCs are giant cells that can be isolated from blood cells. [29][30][31][32][33] The DLD method has many apparent merits like simplicity, low cost, unique flow field for cells' manipulation, high resolution, and low degrees of clogging. On the other hand, it also has some drawbacks; for instance, the inability to sort cells with similar size and unpredictability of the device performance at high throughputs due to flow-induced cell deformation.…”

“…By choosing a designated critical size, smaller or bigger cells than this vital size can be separated. For instance, in CTC separation, CTCs are giant cells that can be isolated from blood cells 29‐33 …”

Zigzag microchannel for rigid inertial separation and enrichment (Z-RISE) of cells and particles

“…16 These devices have been applied in applications such as microfiltration, microseparation, micromixing, and flow cytometry. [17][18][19][20][21][22][23][24] Inertial particle focusing in serpentine microchannels (curvilinear and square-wave form) have attracted interest due to their small footprint, multiplexing ability, and portability. At optimal flow rates, these devices provide improved control on particle position via an induced secondary recirculating (Dean) flow perpendicular to the main flow direction.…”

“…16 These devices have been applied in applications such as microfiltration, microseparation, micromixing, and flow cytometry. 17–24…”