Advances in TEER measurements of biological barriers in microphysiological systems

Nazari, Hojjatollah; Shrestha, Jesus; Naei, Vahid Yaghoubi; Bazaz, Sajad Razavi; Sabbagh, Milad; Thiéry, Jean Paul; Warkiani, Majid Ebrahimi

doi:10.1016/j.bios.2023.115355

Cited by 11 publications

(4 citation statements)

References 121 publications

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“…They all rely on the same principle: apply a current signal to the barrier and then measure the resulting voltage drop [ 176 ]. The Ohm's law method has advantages that only a single frequency needs to be evaluated, and no data fitting is required to obtain the TEER value [ 193 ]. However, Ohm's law method cannot collect information about the battery layer capacitance contained in the spectrum.…”

Section: Indicators Used To Evaluate Microfluidic Intestinal Barrier ...mentioning

confidence: 99%

Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques

Wang,

Li,

Shi

et al. 2024

Materials Today Bio

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Section: Indicators Used To Evaluate Microfluidic Intestinal Barrier ...mentioning

confidence: 99%

Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques

Wang,

Li,

Shi

et al. 2024

Materials Today Bio

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“…Recent advances in nano- and micro-technology have extended the types of sensors available for in-chip biological processes in so-called lab-on-chips, as well as the 3D structures of the channels. Functional readouts to assess barrier integrity, 37 , 38 oxygen concentrations, and inflammatory responses ( e.g. , cytokine profiles and short-chain fatty acid levels) can be included using on-chip biosensors, or by post-analysis of manually collected samples.…”

Section: Advances In Gut-on-chip Systems and Complementarity With Ani...mentioning

confidence: 99%

From animal models to gut-on-chip: the challenging journey to capture inter-individual variability in chronic digestive disorders

Kriaa,

Mariaule,

De Rudder

et al. 2024

Gut Microbes

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Chronic digestive disorders are of increasing incidence worldwide with expensive treatments and no available cure. Available therapeutic schemes mainly rely on symptom relief, with large degrees of variability in patients’ response to such treatments, underlining the need for new therapeutic strategies. There are strong indications that the gut microbiota’s contribution seems to be a key modulator of disease activity and patients’ treatment responses. Hence, efforts have been devoted to understanding host–microbe interactions and the mechanisms underpinning such variability. Animal models, being the gold standard, provide valuable mechanistic insights into host–microbe interactions. However, they are not exempt from limitations prompting the development of alternative methods. Emerging microfluidic technologies and gut-on-chip models were shown to mirror the main features of gut physiology and disease state, reflect microbiota modification, and include functional readouts for studying host responses. In this commentary, we discuss the relevance of animal models in understanding host–microbe interactions and how gut-on-chip technology holds promises for addressing patient variability in responses to chronic digestive disease treatment.

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“…For reviews of biosensing in OOC platforms more broadly, the interested reader is referred other recent articles. 5–9…”

Section: Introductionmentioning

confidence: 99%

Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems

Ugodnikov,

Persson,

Simmons

2024

Lab Chip

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Advances in TEER measurements of biological barriers in microphysiological systems

Cited by 11 publications

References 121 publications

Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques

Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques

From animal models to gut-on-chip: the challenging journey to capture inter-individual variability in chronic digestive disorders

Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems

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