Background: Hematological disorders are quite frequent in all age group. Most of this hematological disorder first present as anemia. Bone Marrow Aspiration plays a major role in the diagnosis of its underlying cause. The aim of this study was to analyze the causes of hematological disorders, its spectrum and to interprete the bone marrow aspiration findings.Materials and Methods: This was a retrospective and prospective study carried out in the department of Pathology of Nepal Medical College in a period of two years. (July 2010 - June 2012). Bone marrow examination of 57 cases of suspected hematological disorders was carried out. All details of the patients were obtained from the record file in the department of pathology.Results: Out of 57 cases of bone marrow aspiration, erythroid hyperplasia was seen in 12 cases (21%). Megaloblastic anemia was seen in 7 cases (12.3%) and microcytic anemia was seen in 4 cases (7%). There were 6 cases (10.5%) of Idiopathic Thrombocypenic Purpura. Acute leukemia was diagnosed in 7 cases (12.3%) and among this acute myeloid leukemia (10.5%) was more common than acute lymphoid leukemia (1.8%). Myelodysplastic syndrome and multiple myeloma was seen in 3.5 % cases each. Aplastic anemia and kalaazar was seen in 5.3% and 1.8% cases respectively.Conclusion: Bone marrow examination is an important step to arrive at the confirmatory diagnosis of many hematological disorders.Journal of Pathology of Nepal (2012) Vol. 2, 309-312DOI: http://dx.doi.org/10.3126/jpn.v2i4.6885
Background: Cervical cancer is a leading cause of mortality and morbidity among women worldwide and most common gynaecological cancer in developing countries. Papanicolaou smear is a simple and cost effective screening test for cervical cancer. The aim of this study is to evaluate and interpret the cervical pap smear cytology in a tertiary hospital. The interpretation and reporting of the pap smear is based on 2001 Bethesda system. Materials and methods:This is a prospective study conducted in a tertiary hospital, Nepal Medical College over a period of two and a half years (January 2013 to June 2015). All cervical pap smears received in the department of Pathology in the study period were included.Results: A total of 4160 cervical pap smears were reported in the study period. Majority of the cases were Negative for Intraepithelial lesion or malignancy (87.9%). Bacterial vaginosis, atrophy and reactive cellular changes associated with inflammation were seen in 5.3%, 2.4% and 1.5% cases respectively. Epithelial cell abnormalities (0.5%) include Atypical squamous cells of undetermined significance, Low grade squamous intraepithelial lesion and High grade intraepithelial lesion. 88% of Low grade squamous intraepithelial lesion was seen in reproductive age group (20-45 years). Conclusion:Cervical cancer is the most common gynaecological cancer in the developing countries. Pap smear is the simple and cost effective screening tool to detect pre invasive cervical epithelial lesions.
Background: Carcinoma of breast has become the major public health problem among females in developing as well as developed countries. In Nepal it comprises 6% of total cancers cases and often diagnosed at advanced stage. Surgical removal or modiied radical mastectomy (MRM) is the most commonly used tools for disease management. The objective of this study is to identify the clinical, macroscopic and microscopic features of MRM specimens. Materials and Methods:This prospective cross-sectional study was carried out at Department of Pathology, Bhaktapur Cancer Hospital, Bhaktapur, Nepal. Macroscopic and microscopic examination provided the tumor size, stage, grade, lymph node status, lympho-vascular invasion and perineural invasion. Data were collected and analyzed using SPSS 16. Results:The study comprised 112 breast cancer patients of which 109 (97.3%) were females and 3 (2.7%) were males. Invasive ductal carcinoma no speciic type was the most common type of breast carcinoma. (84 cases) accounting 75% of total cases. Carcinoma with medullary features was second most common (6 cases) comprising 5.4% cases followed by lobular, papillary, apocrine, mucinous and NST mixed types. Grade II tumors were most frequent grade observed in 76.79% cases followed by Grade I (12.50%) and Grade III (10.71%). Conclusion:As a conclusion invasive ductal carcinoma was the most common histological type breast cancer and the tumors were found at T2 and N3 stage i.e maximum at grade II. Our study provides prognostic signiicance of histo-pathological information in breast cancer management. ABSTRACT INTRODUCTIONBreast cancer is the most frequently occurring cancer among women in the developed as well as developing Pathak R 1 , Jha A 2 , Neupane PR 3 , Chalise S 2 , Basnyat AS 2 1 Department of Pathology, Nepal Medical college Teaching Hospital, Jorpati Kathmandu, Nepal. 2 Department of Pathology, Bhaktapur Cancer Hospital, Bhaktapur, Nepal 3 Department of Surgery, Bhaktapur Cancer Hospital, Bhaktapur, Nepal. countries and it has become the major public health problem worldwide with nearly 1.7 million newly diagnosed cases in 2012 representing 25% of all female cancers. 1,2 Among Nepalese women, breast cancer is the second most common type of cancer accounting 6% of total cancers in Nepal. 3 In Nepal, more than one quarter of the breast cancer is diagnosed in young female and many being diagnosed at an advanced stage with tumors showing more aggressive
Background: Fine needle aspiration cytology is a minimally invasive technique used in the initial diagnosis of different types of lesions located in head and neck region commonly originating from cervical lymph node, thyroid gland, salivary glands and soft tissues. The objective of this study was to evaluate the diagnostic accuracy, sensitivity and speci city of FNAC in various head and neck lesions in correlation with their histopathological examination. Materials and methods: A hospital based prospective study was conducted among 209 patients with palpable head and neck region swellings in the Department of Pathology, Bhaktapur Cancer Hospital and the Department of Pathology, Nepal Medical College from August 2014 to July 2015. FNAC were done from palpable masses of head and neck regions. Data entry and analysis were done using SPSS 17. Result: There were 209 FNAC cases enrolled, out of which lymph node lesions (n=128) were the most common lesions followed by thyroid (n=40), other soft tissues (n=27) and salivary gland (n=14). Reactive lymph nodes, colloid goiter, epidermoid cyst and sialadenosis were the predominant diagnosis of lymph nodes, thyroid gland, soft tissues and salivary gland respectively. Highest accuracy, sensitivity and speci city were observed in thyroid gland, salivary gland and soft tissues. However, four false negative results for malignancy were reported in lymph node lesions. Conclusion: Head and neck region swellings are the commonly encountered conditions. FNAC being highly accurate, sensitive and speci c makes it useful and reliable procedure for screening and diagnosis of palpable masses in head and neck region.
Typhoid fever and paratyphoid fever (also known as enteric fever) are severe systemic illnesses caused by salmonella typhi and S. paratyphi respectively. Enteric fever is prevalent in developing countries including Nepal, where it still remains as a major health problem. There have been reports of pancytopenia with enteric fever which has been attributed to mechanisms like bone marrow suppression, infection associated hemophagocytic syndrome and disseminated intravascular coagulation. We report here a case of severe pancytopenia in enteric fever as a result of bone marrow suppression due to systemic infection. Keywords: enteric fever, pancytopenia, bone marrow suppression
Background: Pleural effusion is a common medical condition with many possible underlying etiologies. However, Tuberculosis is the most common cause of pleural effusion especially in countries like Nepal. Pleural fluid lymphocytosis is seen in tuberculosis, malignancy and few auto-immune diseases. Adenosine Deaminase activity (ADA) level in tubercular pleural effusion is markedly increased compared to non-tubercular effusions. ADA estimation being a simple colorimetric method is suitable for the rapid diagnosis of tubercular effusion. This study aims to correlate the diagnostic efficacy of ADA with the value of differential count (lymphocytosis) in establishing different etiology of pleural effusion. Materials and Methods:This is a cross sectional study of 50 cases with pleural effusion carried out in the department of Pathology, Green city hospital for the duration of Twenty one month's dating from October 2014 to July 2016 AD.Results: Of all, tubercular pleural effusion accounted for 26%. ADA level was raised (≥40U/L) in 92% of Tubercular pleural effusion. The sensitivity and specificity of ADA alone to diagnose tubercular pleural effusion was 92% each and when lymphocytosis alone was considered sensitivity was 85% with specificity of 32% whereas the combined effect of both ADA with lymphocytosis was 100% (sensitivity) and 87% (specificity), 83% (positive predictive value) and 100% (negative predictive value) respectively with statistically significant p value (<0.05). Conclusion:We can conclude that the combination of pleural fluid differential count (lymphocytosis >50%) and ADA level >40U/L provides with much more positive result than each component alone in differentiating tubercular effusion from other etiologies.
A total of 58 cases of cytologically conirmed breast carcinoma were included in this study and correlated with histopathological indings. Robinson's cytological grading was done on cytology smears and modiied Bloom-Richardson grading was done on histological sections. Correlation between these two grading was done by using spearman's correlation coeficient.Results: Cytologically, most common tumor was grade II (62.1%) followed by grade I (19%) and grade III (19%). Histologically, most common tumor was grade II (63.8%) followed by grade III (22.4%) and grade I (13.8%). High concordance rate was found in grade II tumor (80%) with absolute concordance being 65.9%. On cytology, cell dissociation and nuclear margin were determining features (p<0.005). Correlation between cytological grading and histological grading was statistically signiicant (p<0.005).Conclusion: : Robinson's cytological grading is the easy grading method that can be done on cytology smears of the breast carcinoma to achieve relevant information regarding aggressiveness of the tumor and to plan for neoadjuvant chemotherapy preoperatively.
Introduction Unhealthy dietary practices, sedentary lifestyle and obesity have emerged as major risk factors of Non communicable diseases (NCD).[1] In India there is shift in dietary patterns to more ‘Western’ diets rich in saturated fat, refined foods and sugar and low in fibre[2] due to which there is a higher prevalence of traditional cardiovascular disease risk factors such as obesity, physical inactivity, tobacco use and high intake of saturated fat.[3] In 2000, the International Obesity Task Force of the WHO (IOTF-WHO) proposed a modification of National Heart, Lung, and Blood Institute guidelines on overweight/obesity which is as follows : Overweight, 23 to <25; class I obesity, 25 to <30; and class II obesity, ≥30. Redefining the obesity cut-off (BMI >25) creates an “obesity burden” in urban India.[4]
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