Karika (<em>Carica pubesce</em><em>ns</em>)is a typical plant of the Dieng plateau. Previous study showed that <em>Carica</em><em>pubescens</em>contains chemical compound such as flavonoid that play role in analgesic activity. This study was aimed to determine the analgesic activity of etanolic extracts of karika leaves) in vivo using writhing method. The study was conducted on 25 male mice strain Swiss-Webster (20-30 g, 2-3 months) that were randomly divided into 5 groups. Group I was given distilled water 1 mL (p.o) as negative control, group II was given tramadol 50 mg/kgBW (p.o) as positive control, and group III-V received an etanolic extracts of karika leaves in 3 doses, i.e. 20 mg/kgBW, 40 mg/kgBW, and 80 mg/kgBW (p.o), respectively. Acetic acid 0,5% (v/v) was used as pain inductor. The writhe was observed within 1 hour. Data analysis was carried out by using one way ANOVA. The result showed that the ethanol extract of leaves Karika <em>(Carica </em><em>pubescens)</em> have activity as an analgesic at a dose of 20 mg / kg, 40 mg / kg and 80 mg / KgBW (p <0.05), chemically induced, where a dose of 80 mg / KgBW (p.o) produce the most high analgesic activity.
<p class="Abstract">Eel (<em>Anguilla bicolor</em>) is a general fish consumption in many countries. Besides its vitamin rich, eel oil is also known to contain fatty acids like oleic acid and palmitic acid. That is necessary for traditional medicine and as food a supplement. It is known that polyunsaturated fatty acids are recognized to lower blood cholesterol. In this study, fresh eels were extracted using reflux methods. The study was conducted on rat test animals given high-fat diet and PTU (Propylthiouracil). Treatment was given eel fish oil with dose 0.5 ml / kg BW; 1 ml / KgBW and 2 ml / KgBW. The results of eel extraction showed that the metal content is undetectable except Zn metal 11.72 ppm. Eel fish oil affects the total cholesterol decrease at each dose (h <0.05). Known percent increase in total cholesterol after 14 days at a dose of 0.5 ml / kg body weight (-14.10%); 1 ml / kg BW (2.12%) and 2 ml / kg BW (11.37%).</p>
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