The ethanolic extract of mountain papaya (Vasconcellea pubescens A.DC.) fruit against lipid peroxidation of rat liver tissues

Sasongko, Heru; Efendi, Nur Rohman; Sugiyarto,

doi:10.1063/1.5061894

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…28 The principle of the TBARS method is that MDA will form a complex with pink TBA in an acidic atmosphere. 15 The highest MDA level is known in the negative control group induced by alloxan. While the drug control group (glibenclamide) has the lowest MDA levels.…”

Section: Discussionmentioning

confidence: 99%

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Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Sasongko¹,

Lestari²,

Yugatama³

et al. 2020

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Introduction: Mountain papaya (Vasconcellea pubescens A.DC.) and bitter melon (Momordica charantia L.) fruit extract have total flavonoids and some metabolite from its contains. The use of a single dose in the treatment of diabetes is often considered to lack a strong effect. Giving a combination of the compound is a solution to provide a synergistic effect in treatment. Material and Methods: Rat were divided into eight groups (normal, negative control, glibenclamide as a positive control, and five dose extract group). The single dose mountain papaya extract (MPE) and bitter melon extract (BME) were given at 174 mg/kg b.w of MPE, and 380 mg/kg b.w of BME in oral administration.

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Section: Discussionmentioning

confidence: 99%

“…The filtrate was evaporated with a rotary evaporator at 50 0 C until a thick extract was obtained. 15 The method used is the aluminum chloride colorimetric method using a UV-Vis spectrophotometer at λ=439 nm. The standard used is Quercetin concentration series 6.125, 12.5, 25, 50, and 100 ppm.…”

Section: Extraction and Analysis Of Total Flavonoidsmentioning

confidence: 99%

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Sasongko¹,

Lestari²,

Yugatama³

et al. 2020

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“…According to another study, bitter melon contained anthraquinones, glucosinolates (Joseph & Jini 2013), carbohydrates, glycosides, proteins, and amino acids (Shukla & Kashaw 2018;Li et al 2020). In addition, the phytochemical analysis of mountain papaya ethanolic extract showed the presence of flavonoids, tannins, and phenolic compounds (Simirgiotis et al 2009;Laily et al 2012;Sasongko et al 2018). Figure 1 showed that alloxan induced weight loss in the diabetic rat model.…”

Section: Discussionmentioning

confidence: 99%

The Hypolipidemic Effect of Mountain Papaya and Bitter Melon Fruit Ethanolic Extract in Diabetic Rats

Sasongko

Lestari²,

Indasari³

et al. 2022

J.Tropical Biodiversity Biotechnology

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Traditional medicine has been developed rapidly throughout the world to treat hyperlipidemia. However, the use of a single compound in hyperlipidemia treatment usually have low efficacy. Therefore, a combination of ingredients is bound to have more synergistic impact in therapy. This research aimed to examine the hypolipidemic potential of mountain papaya (MPE) and bitter melon fruit ethanolic extract (BME) in alloxan-induced rats. Forty rats divided into eight groups were used in this study. Groups are divided into normal control, negative control, positive control, as well as MPE and BME groups which divided into single doses and three combination doses. Induction of 150 mg/kg alloxan intraperitoneally were performed to generate a model of diabetes and hyperlipidemia. The treatment was carried out for four weeks of the experiment. The single and combination doses of both extracts sufficiently exhibited hypolipidemic activity (p < 0.05). The levels of lipid profiles total such as cholesterol, triacylglycerides, low-density lipoprotein, high-density lipoprotein, and very high-density lipoprotein were decreased after MPE and BME administration (p < 0.05). The combination of MPE and BME also has hypolipidemic action equivalent to simvastatin. The single and combined doses of mountain papaya, as well as bitter melon fruit ethanolic extracts, have the potential to improve the biochemical (lipid profile) modifications of alloxan-induced.

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“…MDA is the end product of free radicals' peroxidation of lipids (Sasongko et al, 2018). The intensity of an organism's oxidative stress response is proportional to the concentration of MDA in vivo (Szeto, 2006).…”

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Nephroprotective effect of milkfish, patin, and snakehead fish oil by suppressing inflammation and oxidative stress in diabetic rats

Sasongko,

Endro Nugroho,

Nurrochmad

et al. 2023

Indonesian J Pharm

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Diabetic nephropathy (DN) has been linked to a number of long-term problems caused by diabetes mellitus. Inflammatory and oxidative stress pathways contribute to DN development and progression. Many studies have shown the preventive advantages of diets rich in substances like anti-inflammatory and antioxidant elements like omega-3 fatty acids (n-3 FA) in preventing DN. Milkfish (Chanos chanos F.), patin (Pangasius micronema Blkr.), and snakehead fish (Chana striata Bloch) are types of fish oils that are known to contain n-3 FA. This study aims to prove the nephroprotective effect of the three types of fish oil in a rat model of diabetes mellitus. Thirty male rats were used in this study. The animals were randomly divided into six groups (n = 5): the non-diabetic group, the diabetes mellitus group, the diabetic with 150 mg/kg metformin orally group, the diabetic with 1000 mg/kg milkfish oil orally group, the diabetic with 1000 mg/kg patin fish oil orally group, and the diabetic with 1000 mg/kg snakehead fish oil orally group. Diabetes models were induced using 65 mg/kg streptozotocin and 230 mg/kg nicotinamide intraperitoneally. The test was carried out for 8 weeks, followed by the observation of the biochemical profiles of blood, urine, oxidative stress, and the immunohistochemistry of the kidneys. A normally and homogeneously distributed test followed by a one-way analysis of variance (ANOVA) and the LSD post hoc test were used to look at the data. At p≤0.05, the data was considered statistically significant. The results showed that serum creatinine levels did not differ significantly after the administration of milkfish, catfish, and snakehead fish oil for 8 weeks (p≥0.05). Different results were shown where the levels of serum BUN, uric acid, urine urea, and microalbumin urine were significantly different after administration of the three types of fish oil (p≤0.05). The same results were shown in oxidative stress (superoxide dismutase, glutathione, and malondialdehyde) and inflammation (interleukin-6 and tumor necrosis factor-α) profiles (p≤0.05). The conclusion is that milkfish, patin, and snakehead fish oils have moderate nephroprotection by suppressing inflammation and oxidative stress.

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The ethanolic extract of mountain papaya (Vasconcellea pubescens A.DC.) fruit against lipid peroxidation of rat liver tissues

Cited by 5 publications

References 16 publications

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

The Hypolipidemic Effect of Mountain Papaya and Bitter Melon Fruit Ethanolic Extract in Diabetic Rats

Nephroprotective effect of milkfish, patin, and snakehead fish oil by suppressing inflammation and oxidative stress in diabetic rats

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