Hepatoprotective Effect of Mountain Papaya (Vasconcellea pubescens A.DC.) Fruit Extract against Acetaminophen-Induced Acute Liver Damage

Sasongko, Heru; Pratiwi, Diah Ayu; Amartiwi, Trias; Efendi, Nur Rohman; Sugiyarto,

doi:10.5220/0008239500660070

Cited by 2 publications

(4 citation statements)

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“…This condition is severe damage and irreversible even with cell regeneration activity. 8 Measurement of GSH levels is done by referring to the Ellman method. In principle, ditio bisnitro benzoate (DTNB) will react with GSH to produce a yellow tionitro benzoate compound.…”

Section: Discussionmentioning

confidence: 99%

“…23 Histological examination carried out qualitatively to see the general morphology of pancreatic cells by counting the number of normal pancreatic cells and pancreatic cells undergoing necrosis in the form of nuclear shrinkage (pyknosis), nucleus rupture (cariorrexis), and disappearance of nucleus (karyolysis) on the Langerhans Island. 8…”

Section: Histological Studymentioning

confidence: 99%

“…Mountain papaya contains flavonoids, alkaloids, polyphenols, cysteine proteases, and papain which are antidiabetic agents. 8,9 Total flavonoids contained in mountain papaya fruit have been permitted as antidiabetic by preventing β cell damage, insulin, and insulin signaling and inhibiting α-glucosidase. 9,10 Bitter melon fruit contains flavonoids, alkaloids, saponins, polysaccharides, proteins, triterpenoids, quinine, and amino acids.…”

Section: Introductionmentioning

confidence: 99%

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Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Sasongko¹,

Lestari²,

Yugatama³

et al. 2020

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Introduction: Mountain papaya (Vasconcellea pubescens A.DC.) and bitter melon (Momordica charantia L.) fruit extract have total flavonoids and some metabolite from its contains. The use of a single dose in the treatment of diabetes is often considered to lack a strong effect. Giving a combination of the compound is a solution to provide a synergistic effect in treatment. Material and Methods: Rat were divided into eight groups (normal, negative control, glibenclamide as a positive control, and five dose extract group). The single dose mountain papaya extract (MPE) and bitter melon extract (BME) were given at 174 mg/kg b.w of MPE, and 380 mg/kg b.w of BME in oral administration.

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Section: Discussionmentioning

confidence: 99%

Section: Histological Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Sasongko¹,

Lestari²,

Yugatama³

et al. 2020

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“…Mangosteen (Garcinia mangostana L.) and mountain papaya (Vasconcellea pubescens A.DC.) are some types of plants that are often found in Indonesia (Sasongko et al, 2019). Mountain papaya is a typical plant of the Dieng plateau which has been known to contain flavonoid compounds that can be used as exogenous antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Supplementation of Garcinia mangostana Linn and Vasconcellea pubescens A.DC extract reduced exercise-induced oxidative stress in rats

et al. 2021

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The objective of this study was to see how supplementation with Garcinia mangostana extract (GME) and Vasconcellea pubescens extract (VPE) affected exercise performance and oxidative stress in intensely exercised rats. Twenty-five male rats were used in the study. Rats were divided into five groups: normal, stress oxidative control, combination GME:VPE (50:50), combination GME:VPE (75:25), and combination GME:VPE (25:75) groups. The antioxidant activity of a single extract from the literature was used to make the percentage comparison between extracts. The chronic exercise was done by swimming at 10 m/day for two weeks. Rats in the acute exercise groups were treated by swimming on the pail containing water. Blood samples were collected from the orbital sinus to determine hematological parameters. Liver tissue samples for the analysis of malondialdehyde (MDA) and glutathione (GPx) markers. Data analysis was performed statistically using One Way ANOVA. The combination of GME and VPE was shown to be effective in reducing oxidative stress and increasing MDA and GPx enzyme activity. The administration of both extracts also showed changes in the hematological profile.

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Hepatoprotective Effect of Mountain Papaya (Vasconcellea pubescens A.DC.) Fruit Extract against Acetaminophen-Induced Acute Liver Damage

Cited by 2 publications

References 0 publications

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Supplementation of Garcinia mangostana Linn and Vasconcellea pubescens A.DC extract reduced exercise-induced oxidative stress in rats

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