RESUMO: Realizou-se um estudo retrospectivo com o objetivo de determinar os tipos de neoplasmas em bovinos e a sua frequência. Foram analisados os casos de necropsias e biopsias de bovinos com diagnóstico de neoplasia, submetidos ao Setor de Patologia Veterinária da Universidade Federal do Rio Grande do Sul (SPV-UFRGS), entre janeiro de 2005 e dezembro de 2014. De um total de 4.188 exames realizados em bovinos, 154 foram diagnosticados como neoplasmas. Destes, 100 casos foram a causa da morte, 41 foram achados de frigorífico e 13 casos eram biopsias de cirurgias realizadas por veterinários de campo. Os neoplasmas ocorreram com maior frequência em bovinos adultos (96/154), fêmeas (125/154) e a raça mais acometida foi a Holandesa (79/154). Os neoplasmas mais frequentes foram linfoma (73/154), carcinoma de células escamosas (28/154), papiloma (9/154), melanoma (6/154) e feocromocitoma (6/154). Os sistemas mais acometidos foram o hemopoiético (75/154) e tegumentar (25/154). Conclui-se que o linfoma e o carcinoma de células escamosas são os neoplasmas mais frequentes em bovinos diagnosticados no SPV-UFRGS, Brasil.

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ABSTRACT.-Panziera W., Gonçalves M.A., Oliveira L.G.S., Lorenzett M.P., Reis M., Hammerschmitt M.E., Pavarini S. Characterization and evolution of liver lesions during the outbreak are also described. Two hundred and six 4-month-old female calves were weaned and placed in a 25-hectare pasture heavily infested by S. brasiliensis at of varying growth stages. The calves remained in this pasture for three months and were later transferred to another area where six calves aged 7-8-month-old developed clinical signs including unthriftiness, diarrhea, and subcutaneous dependent edema in the submandibular region. All these six affected calves died within 15 days from the onset of clinical signs and one of those was necropsied. Grossly the first of three patterns of hepatic lesions described in this report was observed and it was characterized by an enlarged liver, with round borders and an orange hue to the capsular and cut surfaces. Histologically there was marked diffuse vacuolar hepatocellular degeneration, bilestasis, hepatocellular megalocytosis, and mild bile duct proliferation and periportal fibrosis. Two months after the onset of the outbreak, in another visit to the farm, it was observed that an additional 28 calves got sick and 14 died. Affected calves observed in this second on-site visit were 9-10 month-old and their main clinical sign was photosensitization characterized by varying degrees of photophobia, tearing from the eyes, marked drooling, mucopurulent ocular discharge, increased nasal secretion, and ventral diphtheric glossitis. Two of the fourteen calves that died were necropsied and displayed the second pattern of hepatic lesions observed in the outbreak. Liver had smooth and whitish capsular surfaces and a moderate decrease in size. There was moderate irregularity to the cut surface of hepatic parenchyma and pale areas intercalated with red ones. Histologically there was marked periportal fibrosis, marked bile duct proliferation, hepatocellular megalocytosis, focal areas of hepatocellular necrosis, and hemorrhage and veno-occlusive changes. In this second on-site visit, GGT serum activity was determined in 15 affected calves and 13 of them had increased values (26-175 U/L). Seven months after the onset of the outbreak, a third visit was made to the farm when was learned that and additional 27 calves have been affected, 23 of which died within a period of 40 days. At the necropsy of three of these calves the third pattern of hepatic lesions were observed. The liver was decreased in size and markedly firm. The capsular surface was smooth and whitish and the capsular surface 1 Recebido em 1 de junho de 2016.Aceito para publicação em 29 de agosto de 2016.

T. micrantha poisoning in horses causes predominantly a neurological disease, with minimal to absent hepatic lesions.

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Poisoning by the toxic species of Baccharis is an important cause of death in farm animals. Baccharis coridifolia and Baccharis megapotamica are the most common and most important of this genus. Epidemiological, clinical and pathological aspects of a natural outbreak of intoxication by Baccharis megapotamica var. weirii are described in goats. Eleven young goats from a herd of 152 goats were affected by an acute fatal disease. The cases occurred in a small farm in the municipality of Viamão, State of Rio Grande do Sul, southern Brazil. Large patches of blooming Baccharis megapotamica var. weirii were observed in the pastures where the goats were held, especially in wet and flooded spots. Affected goats were between six months to one year old and all showed signs including apathy, anorexia, weakness, diarrhea, dehydration, abdominal pain, bloat, decubitus and death. The clinical course was 12-24 hours. Three out of the eleven goats dead from the toxicosis were necropsied. Changes present in all necropsied goats included dehydration, liquid contents in the rumen, reddening, erosions and ulcers in the mucosae of the forestomachs, abomasum, and intestine. One goat had marked hemorrhage of mesenteric lymph nodes. Histological lesions of all animals included hyperemia as well as degenerative, necrotic, and ulcerative changes in the epithelial lining of rumen, reticulum, and omasum. Mucosae of the abomasum and of some sections of small and large intestines were also affected. Necrosis of lymphoid tissue was observed in mesenteric lymph nodes and in the lymphoid aggregates in intestine and in the follicles of spleen.INDEX TERMS: Poisonous plants, Baccharis megapotamica var. weirii, plant poisoning, diseases of goats, pathology, gastrointestinal tract.

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Background: Contagious ecthyma is a viral disease caused by a Parapoxvirus, which affects primarily sheep and goats. The disease has a worldwide distribution and is characterized by cutaneous pustules and crusts mainly in the muzzle and lips. Although the disease has a worldwide distribution, there are few reports in the literature of contagious ecthyma outbreaks in Brazil. Moreover, this is an important disease, as well as causing huge economic losses due to high morbidity rates, is also a zoonosis occupational character. This report describes the epidemiological, clinical, and anatomopathological aspects of an outbreak of contagious echtyma in sheep in the State of Rio Grande do Sul, Brazil. Case: Cases were observed on January and February of 2016. Seventeen out of 45 Texel sheep were affected including fve 4-6-month-old lambs, three 7-12-month-old male sheep and nine 2-year-old ewes. Before the outbreak, a Texel ram was introduced in the herd as replacement. Clinically, affected sheep had pustules, ulcers, and crusts in the lips, labial commissures, muzzle, and nasal bridge. They also presented dyspnea, submandibular and facial subcutaneous edema. One of the affected sheep was euthanized due to the poor prognosis. At necropsy, the lesions observed clinically were confrmed. Histopathology of the skin in the lips and muzzles showed marked acanthosis of the epidermis, orthokeratotic and parakeratotic hyperkeratosis of the stratum corneum, intracorneal vesicles and pustules, as well as hydropic degeneration and apoptosis of keratinocytes. This lesions led to epidermal serocellular crusting. Histologically and ultrastructurally respectively, inclusion bodies or viral particles were not observed. Approximately 45 days after the diagnosis there were no new cases of echtyma in the herd. Discussion: The diagnosis of contagious ecthyma in these sheep was based on epidemiological, clinical, and pathological fndings. In sheep and goats the disease affects mainly lambs, kids, and lactating females, although sheep from both sexes, and all breeds and ages are susceptible. In this outbreak, sheep of different categories were affected with morbidity about 37%. Carrier sheep and contaminated fomites are the main forms of transmission. In this outbreak, it is presumed that the introduction in the herd of a male carrying the virus was the source of infection to the other sheep. Clinically, it was notice a variation in the clinical signs. Initial lesions were almost imperceptible, and latest lesions were more severe, with a predominance of proliferative crusted changes in the lips and muzzle. The facial and submandibular edema in some sheep was an unusual manifestation of the disease. Gross and microscopic fndings observed in these sheep contributed to the defnitive diagnosis of the disease. Histologically, despite inclusions were not observed, hyperkeratosis, acanthosis, pustules, and degenerative and necrotic changes in the epithelium are typical lesions of contagious ecthyma. It is suggested that the viral particles and the inclusion bodies were not detected by electron microscopy and histology because the necropsied sheep presented a chronic clinical course of the disease. The association of epidemiological, clinical, and pathological fndings allowed the defnitive diagnosis of contagious ecthyma, although inclusions and viral particles were not observed. The introduction of a virus carrier was the likely source of the disease in a non-immune herd. Keywords: diseases of sheep, viral diseases, Parapoxvirus, pustular dermatitis, orf