CTLA-4 molecule is an important inhibitor of T-lymphocyte activation. Several single nucleotide polymorphisms (SNPs) in the CTLA-4 gene were found, and their associations with many human diseases were described. So far, however, such studies have not been performed in psoriasis vulgaris in Caucasoids. Therefore, we examined the distribution of three CTLA-4 SNPs: -1147C/T, -318C/T and +49 A/G in 116 patients with psoriasis vulgaris and 123 healthy blood donors using the polymerase chain reaction-restriction fragment length polymorphism method. For all three SNPs, the frequencies of alleles, genotypes and three-point haplotypes were very similar in patients and controls, suggesting no contribution of these genetic variants to psoriasis.
459solitary finding, with no association with neurological and ophthalmological disease and the latter may be assoeiated with mental retardation, epilepsy and other brain or ophthalmologic abnormalities (1-4). Secondary CVG may appear at any age, skin folds are usually asymmetric and histology reveals various alterations depending on underlying causes such as tumours, nctirofibromas, cerebriform intradermal nevi and inflammatory conditions. Systetnic disorders associated with seeondary CVG include acromegaly, myxedema, amyloidosis or pachydertnoperiostosis (1^).The diagnosis of CVG can be made clinically, but the length and styling of hair makes it difficult to detect the characteristic features of CVG. A few reports of CVG used computed tomography or MRl as a diagnostic method, however, it is difficult to reveal the entire pattern ofthe scalp lesions by these methods (5-7). We found 3D MRl ofthe head could show the characteristic furrows and ridges of CVG more obviously.
Our results show that mAb show OV-TL3 is the best marker for endometrioid carcinomas and confirmed that mAbs OV632, OC125 and OV-TL3 could be good complementary markers for differentiating malignant and benign lesions in the ovary. The percentage content of all ovarian carcinoma-associated antigens in solid tumors and respective cyst fluid cells was comparable.
Pyoderma gangrenosum (PG) is a progressive cutaneous necrosis of unknown origin. We report a case of PG presenting with periungual lesions. A 57-year-old woman was on treatment with ciclosporin A for PG. During tapering of the ciclosporin A dose, proliferating periungual lesions developed on the third and fourth finger of the left hand, the fourth finger of the right hand, and on the right great toe and the left fifth toe. All lesions appeared within a 4-week period. These abnormalities were ulcerated, involved about one-third of the distal part of the lateral nail folds including the part of nail fold bordering on the free edge of the nails, and were very painful. The skin biopsy was consistent with that seen in PG. Increasing the ciclosporin A dose led to significant improvement in the periungual lesions within the next few weeks and complete resolution within 6 months.
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