Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris

Luszczek, Wioleta; Mańczak, Maria; Cisło, M; Nockowski, Piotr; Wiśniewski, Andrzej; Jasek, Monika; Kuśnierczyk, Piotr

doi:10.1016/j.humimm.2004.05.008

Cited by 134 publications

(111 citation statements)

References 31 publications

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“…[29][30][31][32][33][34][35] Our initial statistical analysis indicated a possible involvement of the activating KIR2DS2 and the inhibitory KIR2DL2 in the development of UC. Both genes displayed a high level of linkage disequilibrium with each other (previously reported in Hsu et al 39 ), occurring independently in only three of the samples genotyped in this study.…”

Section: Discussionmentioning

confidence: 89%

“…[29][30][31][32][33]35,38 Analysis revealed KIR2DL3 in the presence of HLA-C1 as the dominant association, significantly reduced in UC patients (P ¼ 0.019, odds ratio (OR) ¼ 0.577, 95% confidence interval (CI) ¼ 0.364-0.915), and the loss of significance with KIR2DL2 and -2DS2 (Figure 1). KIR2DL2 and -2DS2 in the presence of their shared ligand HLA-C1 also failed to reach significance (-2DL2/HLA-C1: OR ¼ 1.311, 95% CI ¼ 0.881-1.950; -2DS2/HLA-C1: OR ¼ 1.286, 95% CI ¼ 0.866-1.911).…”

Section: Resultsmentioning

confidence: 99%

“…Analysis of KIR/HLA ligand combination is increasingly of interest in the genetic study of inflammatory disorders, resulting in the discovery of KIR associations with psoriasis vulgaris, 29,30 psoriatic arthritis, 31 scleroderma, 32 rheumatoid arthritis 33 and type I diabetes. 34,35 In addition, celiac disease has been linked to 19q13.4, 36 where the KIR cluster is located, although genotype analysis of a limited number of KIR genes (KIR2DL1, -2DL2, -2DL3 and -2DL5) failed to detect an association.…”

Section: Introductionmentioning

confidence: 99%

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Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility

et al. 2006

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Killer immunoglobulin-like receptors (KIRs) are expressed on natural killer cells and some T-cell subsets and produce either activation or inhibitory signals upon binding with the appropriate human leucocyte antigen (HLA) ligand on target cells. Recent genetic association studies have implicated KIR genotype in the development of several inflammatory conditions. Ulcerative colitis (UC) is an inflammatory disorder of the colonic mucosa that results from an inappropriate activation of the immune system driven by host bacterial flora. We developed a polymerase chain reaction-sequence specific primer (SSP)-based assay to genotype 194 UC patients and 216 control individuals for 14 KIR genes, the HLA-Cw ligand epitopes of the KIR2D receptors and a polymorphism of the lectin-like-activating receptor NKG2D. Initial analysis found the phenotype frequency of KIR2DL2 and -2DS2 to be significantly increased in the UC cohort (P ¼ 0.030 and 0.038, respectively). Logistic regression analysis revealed a protective effect conferred by KIR2DL3 in the presence of its ligand HLA-Cw group 1 (P ¼ 0.019). These results suggest that KIR genotype and HLA ligand interaction may contribute to the genetic susceptibility of UC.

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Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility

et al. 2006

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“…Originally, our typing using primers described by Łuszczek et al 18,19 revealed relatively high representation of unusual genotype containing KIR2DL3 gene in the absence of KIR2DL1. Retyping of all KIR2DL1-negative samples with recently described primers 20 revealed the presence of KIR2DL1 gene in all KIR2DL3-positive samples, whereas KIR2DL3-negative individuals persisted negative expect for one 2DL1 þ 2DL3 À control person.…”

Section: Resultsmentioning

confidence: 98%

“…18,19 Samples typed negative for KIR2DL1 were retyped using new primers of Vilches et al 20 Statistical analysis Differences between controls, patients and patient subgroups were estimated using the two-tailed Fisher's exact test and GraphPad InStat 3 software. The correction of P-values (if o0.05) for the number of comparisons (11 genes and 7 or 3 subgroups of patients) was calculated using the formula of Svejgaard and Ryder.…”

Section: Kir Genotypingmentioning

confidence: 99%

Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis

et al. 2007

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We investigated whether killer cell immunoglobulin-like receptor (KIR) genes are risk factor(s) for rheumatoid arthritis (RA) and its clinical manifestations. One hundred and seventy-seven RA patients and 243 healthy individuals were tested for the presence of 11 KIR genes using PCR-SSP method. The frequencies of KIRs in patients with RA were similar to the frequencies in controls. However, RA patients positive for KIR2DL3 and negative for KIR2DS3 had earlier disease diagnosis. Additionally, KIR2DL2 and KIR2DS2 were significantly more frequent among RA patients with extra-articular manifestations and in its subgroup with vasculitis than in controls and in patients without these complications. Furthermore, the frequencies of KIR2DS1 and KIR3DS1 were lower in patients without bone erosions compared with healthy individuals. Relationships between the presence or absence of autoantibodies (rheumatoid factor and anti-cyclic citrullinated peptide) and KIR frequencies were also evaluated, but no significant differences were observed. These results suggest that particular clinical manifestations of RA may have different genetic backgrounds with respect to KIR genotype.

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Human Natural Killer Receptors, Co‐Receptors, and Their Ligands

Biassoni

Malnati

2009

CP in Immunology

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In the last 20 years, the study of human natural killer (NK) cells has moved from the first molecular characterizations of very few receptor molecules to the identification of a plethora of receptors displaying surprisingly divergent functions. Our laboratory has contributed to the description of inhibitory receptors and their signaling pathways, important in fine regulation in many cell types, but unknown until their discovery in the NK cells. Inhibitory function is central to regulating NK-mediated cytolysis, with different molecular structures evolving during speciation to assure its persistence. Only in the last ten years has it become possible to characterize the NK triggering receptors mediating natural cytotoxicity, leading to an appreciation of the existence of a cellular interaction network between effectors of both natural and adaptive immunity. This report reviews the contemporary history of molecular studies of receptors and ligands involved in NK cell function, characterizing the ligands of the triggering receptor and the mechanisms for finely regulating their expression in pathogen-infected or tumor cells.

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Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris

Cited by 134 publications

References 31 publications

Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility

Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility

Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis

Human Natural Killer Receptors, Co‐Receptors, and Their Ligands

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