Keratoacanthoma-like Cutaneous Metastasis of Lung Cancer: a Learning Point

Abstract

459solitary finding, with no association with neurological and ophthalmological disease and the latter may be assoeiated with mental retardation, epilepsy and other brain or ophthalmologic abnormalities (1-4). Secondary CVG may appear at any age, skin folds are usually asymmetric and histology reveals various alterations depending on underlying causes such as tumours, nctirofibromas, cerebriform intradermal nevi and inflammatory conditions. Systetnic disorders associated with seeondary CVG include acromegaly, myxedema, amyloidosis or pachydertnoperiostosis (1^).The diagnosis of CVG can be made clinically, but the length and styling of hair makes it difficult to detect the characteristic features of CVG. A few reports of CVG used computed tomography or MRl as a diagnostic method, however, it is difficult to reveal the entire pattern ofthe scalp lesions by these methods (5-7). We found 3D MRl ofthe head could show the characteristic furrows and ridges of CVG more obviously.

Multiple eruptive plaques on the scalp

“…There are fewer than ten published cases of keratoacanthoma-like skin metastasis [5,6]. The lung is the main internal organ related to this type of cutaneous metastasis, which appears most frequently on the lip [7].…”

Keratoacanthoma-like nodules as first manifestation of metastatic epithelioid trophoblastic tumor

“…Cutaneous metastases of internal malignancies with keratoacanthoma like morphology are extremely rare [14], with fewer than 20 cases reported until now [12]. Lung, larynx, breast, esophagus, bronchus and renal cancer, mesothelioma, angiosarcoma, chondrosarcoma, anaplastic large cell lymphoma, and malignant melanoma are the primary malignancies accounting for the majority of these reports [12][13][14]19]. In the reported cases, keratoacanthoma-like cutaneous metastases tend to have a biologic behavior and appearance similar to that of an idiopathic keratoacanthoma: a solitary, asymptomatic, rapidly growing, firm, dome-shaped nodule with a central keratin-filled crater that grows rapidly in 4-to-6 weeks and spontaneously involutes within 6 months [15].…”

Multiple eruptive Plaques auf der Kopfhaut

“…Es existieren insgesamt weniger als zehn veröffentlichte Fallberichte über Keratoakanthom-ähnliche Hautmetastasen [5,6]. Die Lunge ist das innere Organ, das am ehesten mit dieser Form der Hautmetastasen in Verbindung gebracht wird, die vor allem an der Lippe auftreten [7].…”