A Role for KIR Gene Variants Other Than KIR2DS1 in Conferring Susceptibility to Psoriasis

Płoski, Rafał; Luszczek, Wioleta; Kuśnierczyk, Piotr; Nockowski, Piotr; Cisło, M; Krajewski, Paweł; Malejczyk, Jacek

doi:10.1016/j.humimm.2006.04.001

Cited by 23 publications

(21 citation statements)

References 17 publications

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“…We observed also some effects of other KIR genes in psoriatic patients positive for KIR2DS1 : namely, increased frequency of a deletion variant of KIR2DS4 and decreased frequency of KIR2DS3 and KIR2DS5 gene in comparison to KIR2DS1 -positive controls (Ploski et al, 2006). A seemingly protective effect of KIR2DS5 gene presence was seen also in other diseases (Nowak et al, 2010).…”

Section: Skin Diseases: Psoriasis and Atopic Dermatitismentioning

confidence: 63%

Killer Cell Immunoglobulin-Like Receptor Gene Associations with Autoimmune and Allergic Diseases, Recurrent Spontaneous Abortion, and Neoplasms

Kuśnierczyk¹

2013

Front. Immun.

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Killer cell immunoglobulin-like receptors (KIRs) are a family of cell surface inhibitory or activating receptors expressed on natural killer cells and some subpopulations of T lymphocytes. KIR genes are clustered in the 19q13.4 region and are characterized by both allelic (high numbers of variants) and haplotypic (different numbers of genes for inhibitory and activating receptors on individual chromosomes) polymorphism. This contributes to diverse susceptibility to diseases and other clinical situations. Associations of KIR genes, as well as of genes for their ligands, with selected diseases such as psoriasis vulgaris and atopic dermatitis, rheumatoid arthritis, recurrent spontaneous abortion, and non-small cell lung cancer are discussed in the context of NK and T cell functions.

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Section: Skin Diseases: Psoriasis and Atopic Dermatitismentioning

confidence: 63%

Killer Cell Immunoglobulin-Like Receptor Gene Associations with Autoimmune and Allergic Diseases, Recurrent Spontaneous Abortion, and Neoplasms

Kuśnierczyk¹

2013

Front. Immun.

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“…According to the inclusion criteria, 18 studies with full-text were included in this meta-analysis (Rani et al, 1998;Gonzalez et al, 1999;Asumalahti et al, 2000;Brazzelli et al, 2000;Gudjonsson et al, 2003;Luszczek et al, 2003;Zhang et al, 2003;Sánchez et al, 2004;Martínez-Borra et al, 2003Holm et al, 2005a,b;Chang et al, 2004Chang et al, , 2005Chang et al, , 2006Płoski et al, 2006;Jobim et al, 2008;Fojtíková et al, 2009) and 127 studies were excluded. The flow chart for the study selection is summarized in Figure 1.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

Wu¹,

Wu²,

Liu³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a metaanalysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled odds ratio (OR) and 95% confidence interval (95%CI). We found significant associations between HLA-Cw*0602 polymorphism and psoriasis risk in the comparisons of positive versus negative alleles (OR = 4.55, 95%CI = 3.65-5.67, P < 0.00001); positive homozygote versus negative homozygote combined with heterozygote (OR = 14.00, 95%CI = 8.47-23.15, P < 0.00001); positive homozygote combined with heterozygote versus negative homozygote (OR = 5.11, 95%CI = 3.86-6.76, P < 0.00001); positive homozygote versus negative homozygote (OR = 23.03, 95%CI = 13.95-38.00, P < 0.00001), and positive homozygote versus heterozygote (OR = 4.21, 95%CI = 2.35-7.00, P < 0.00001). In conclusion, the positive allele of HLA-Cw*0602 polymorphism appears to be a risk factor for psoriasis.

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“…15,18,23,24 A number of studies has been conducted to identify possible associations between autoimmune conditions and KIR genes. [25][26][27][28][29][30][31][32][33][34][35] In particular, a number of works demonstrate 5 These authors contributed equally to this work. 16 Among the numerous KIR genes, the KIR3DL1/3DS1 locus is of particular interest with respect to AS because KIR3DL1 is the only KIR that recognizes HLA-B molecules of the Bw4 serotype, including HLA-B27.…”

Section: Introductionmentioning

confidence: 99%

Contribution of functional KIR3DL1 to ankylosing spondylitis

et al. 2010

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Increasing evidence points to a role for killer immunoglobulin-like receptors (KIRs) in the development of autoimmune diseases. In particular, a positive association of KIR3DS1 (activating receptor) and a negative association of KIR3DL1 (inhibitory receptor) alleles with ankylosing spondylitis (AS) have been reported by several groups. However, none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1. To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS, we analyzed the frequencies of alleles and genotypes encoding functional (KIR3DL1*F) and non-functional (KIR3DL1*004) receptors. We genotyped 83 AS patients and 107 human leukocyte antigen (HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR, which distinguishes KIR3DS1, KIR3DL1*F and KIR3DL1*004 alleles. For the patients carrying two functional KIR3DL1 alleles, those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles, which are functional but are expressed at low levels. KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004. This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor. However, analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F. The activation of either natural killer (NK) or T cells via the KIR3DS1 receptor can be one of the critical events in AS development, while the presence of the functional KIR3DL1 receptor has a protective effect. Nevertheless, even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS.

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A Role for KIR Gene Variants Other Than KIR2DS1 in Conferring Susceptibility to Psoriasis

Cited by 23 publications

References 17 publications

Killer Cell Immunoglobulin-Like Receptor Gene Associations with Autoimmune and Allergic Diseases, Recurrent Spontaneous Abortion, and Neoplasms

Killer Cell Immunoglobulin-Like Receptor Gene Associations with Autoimmune and Allergic Diseases, Recurrent Spontaneous Abortion, and Neoplasms

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

Contribution of functional KIR3DL1 to ankylosing spondylitis

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