Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

Abstract

ABSTRACT. Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a metaanalysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled odds ratio (OR) and 95% confidence interval (95%CI). We found significant associations between HLA-Cw*0602 polymorphism and psoriasis risk in the comparisons of positive versus negative alleles (OR = 4.55, 95%CI = 3.65-5.67, P < 0.00001); positive homozygote versus negative homozygote combined with heterozygote (OR = 14.00, 95%CI = 8.47-23.15, P < 0.00001); positive homozygote combined with heterozygote versus negative homozygote (OR = 5.11, 95%CI = 3.86-6.76, P < 0.00001); positive homozygote versus negative homozygote (OR = 23.03, 95%CI = 13.95-38.00, P < 0.00001), and positive homozygote versus heterozygote (OR = 4.21, 95%CI = 2.35-7.00, P < 0.00001). In conclusion, the positive allele of HLA-Cw*0602 polymorphism appears to be a risk factor for psoriasis.

Meta-analysis of the association between psoriasis and human leucocyte antigen-B

“…[20][21][22][23][24] Very few reviews have conducted quantitative analysis, except for a meta-analysis of HLA-Cw*06, the association of which with psoriasis has been confirmed. [25][26][27][28][29] As a result, there is no consensus conclusion about the association between psoriasis and HLA, or what roles HLA alleles play in psoriasis.…”

Four Polymorphisms ofVEGF(+405C>G, −460T>C, −2578C>A, and −1154G>A) in Susceptibility to Psoriasis: A Meta-Analysis

“…First, the sample size in our study was relatively modest, especially in ethnicity subgroup analysis, so the power of the association analysis was inevitably low. Second, as with other complex traits, psoriasis is polygenic and may also be modulated by several other genetic markers beyond VEGF, including HLA-Cw6, TNF-a, IL23R, and several other candidate genes (Li et al, 2007;Wu et al, 2011;Zhu et al, 2012). Thus, our meta-analysis emphasizes that elucidating the pathogenesis of psoriasis would demand further evaluation of the potential gene-gene interactions.…”

Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population

“…Psoriasis is an immune-mediated, genetic skin disorder (Wu et al, 2011;Boehncke and Schön, 2015). Abundant evidence shows that single nucleotide polymorphisms (SNPs) of the caspase recruitment domain (CARD) family member 14 (CARD14) gene are implicated in this condition (Jordan et al, 2012a,b;Tsoi et al, 2012;Qin et al, 2014;Aizu et al, 2015).…”