Four Polymorphisms of<i>VEGF</i>(+405C&gt;G, −460T&gt;C, −2578C&gt;A, and −1154G&gt;A) in Susceptibility to Psoriasis: A Meta-Analysis

Qi, Min; Huang, Xiaoyuan; Zhou, Lei; Zhang, Jianglin

doi:10.1089/dna.2013.2252

Cited by 21 publications

(14 citation statements)

References 40 publications

(45 reference statements)

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“…Several single-nucleotide polymorphisms, such as þ405 C/G, e1154 G/A, e634 G/C in 5 0 untranslated region and þ936 C/T, located in the 3 0 untranslated region of the VEGF-A gene are often associated with different expression of the VEGF gene. This can lead to pathological angiogenesis in progressively growing tumor formations, diseases of the cardiovascular system, psoriasis, and others [48,49].…”

Section: Clinical Perspectivesmentioning

confidence: 99%

Molecular regulation and role of angiogenesis in reproduction

Rizov¹,

Andreeva

Dimova

2017

Taiwanese Journal of Obstetrics and Gynecology

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Angiogenesis is an essential process for proper functioning of the female reproductive system and for successful pregnancy realization. The multitude of factors required for physiological angiogenesis and the complexity of regulation of their temporal-spatial activities contribute to aberrations in human fertilization and pregnancy outcomes. In this study, we reviewed the current knowledge of the temporal expression patterns, functions, and regulatory mechanisms of angiogenic factors during foliculogenesis, early implantation/placentation and embryo development, as well as recurrent spontaneous abortions. Angiogenic factors including vascular endothelial growth factors and angiopoietins have documented roles in the development of primordial follicles into mature antral follicles. They also participate in decidualization, which is accompanied by the creation of an extensive network of vessels in the stromal bed that support the growth of the embryo and the placenta, and maintain early pregnancy. During placentation angiogenic and angiomodulatory cytokines, T and B lymphocytes and macrophages affect angiogenesis in a context-dependent manner. Defects in angiogenesis at the maternal-fetal interface contribute to miscarriage in humans. The establishment of more polymorphisms in the genes involved in angiogenesis/vasculogenesis, and their pathological phenotype and expression could give opportunities for prediction, creating a therapeutic strategy, and treatment of diseases related to female reproductive health and problematic conception.

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Section: Clinical Perspectivesmentioning

confidence: 99%

Molecular regulation and role of angiogenesis in reproduction

Rizov¹,

Andreeva

Dimova

2017

Taiwanese Journal of Obstetrics and Gynecology

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“…Several SNPs have been described for the VEGF gene which have been studied in various disease conditions in different populations (Qi, Huang, Zhou, & Zhang, 2014). Linkage disequilibrium (LD) has been observed across the VEGF gene (Stevens, Soden, Brenchley, Ralph, & Ray, 2003).…”

Section: Discussionmentioning

confidence: 99%

Is the +405 G/C single nucleotide polymorphism of the vascular endothelial growth factor (VEGF) gene associated with late‐onset vitiligo?

Almasi‐Nasrabadi

Amoli

Robati

et al. 2019

Int J Immunogenetics

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The increasing body of evidence for the relationship between the vascular endothelial growth factor (VEGF) polymorphism and autoimmune disorders combined with the enhanced expression of this angiogenic factor in vitiligo makes VEGF a very interesting candidate gene to be investigated in vitiligo. The aim of this study was to evaluate the possible associations between the +405 G/C single nucleotide polymorphisms (SNP) of the VEGF gene (rs2010963) and vitiligo. The independent case–control population sample of 152 patients with vitiligo and 152 matched controls was evaluated in this study. A questionnaire was completed for each vitiligo patient to document the demographic and clinical characteristics of the patients. All enrolled individuals had a venous blood sample collected. Genotype frequencies for +405 G/C VEGF gene polymorphism were determined using polymerase chain reaction (PCR) amplification and restriction fragment length polymorphism (RFLP) analysis. There were no significant differences in genotype or allele distributions for this SNP between cases and controls. However, we observed a significant association between GG genotype and higher age at onset of vitiligo (p = 0.04). Moreover, patients stratification revealed a significant increase in the frequency of GG genotype compared to CC + CG genotypes in patients with the late onset (≥20 years) vitiligo (p = 0.05). Although these results are not conclusive, they could potentially lead to considering the angiogenic factors as a potential target for therapy in late‐onset vitiligo.

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“…To date, only nine case-control studies, two meta-analyses, and two therapeutic response SNP studies of VEGFA gene SNPs in psoriasis have been published, and none in Turkish population 34 35 36 37 38 39 40 41 42 43 44 45 46 . The results of these previous reports are controversial and associations of VEGFA gene SNPs with psoriasis remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Genetic Risk Factors for Psoriasis in Turkish Population: -1540 C/A, -1512 Ins18, and +405 C/G Polymorphisms within the Vascular Endothelial Growth Factor Gene

et al. 2016

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BackgroundEvidence regarding the vascular endothelial growth factor A (VEGFA) as a potent mediator of angiogenesis and inflammation in psoriasis has revealed variations in this gene as surrogate markers of psoriasis.ObjectiveVEGFA gene polymorphisms (-1540 C/A, -1512 Ins18, -460 T/C, and +405 C/G) in psoriasis susceptibility in Turkish population were investigated.MethodsA total of 200 age, sex and ethnicity-matched psoriatic and healthy individuals were examined for clinical type, response to therapy, serum VEGFA and its receptor levels, genotypes and haplotypes.ResultsThe +405 GG, +405 CG, -1540 CA, and -1512 +Ins18 genotypes conferred a significant risk for developing psoriasis. The C-InsTC haplotype in the controls and C+InsTG, A+InsTC, and A-InsTG haplotypes in psoriatic patients were observed to be significantly high. Increased serum levels of VEGFA were detected in psoriatic patients with the C-InsTC haplotype than that in the controls. The +405 GG genotype was significantly more frequent in psoriatic patients with a positive family history, and the moderate form of psoriasis was more frequent among C+InsTG haplotype carriers than that among the other patients. The +405 GG genotype was found to be more frequent in patients responding to oral retinoids. Serum VEGFR1/FLT1 and VEGFR2/KDR levels were not significantly different when psoriatic patients and controls were stratified based on the risk polymorphic variants.ConclusionVEGFA gene +405 GG and CG, -1512+Ins18, and -1540 CA genotypes are associated with an increased risk of psoriasis in Turkish population. The G allele at +405 and an 18-bp insertion at -1512 are primarily the risk factors for psoriasis, and this risk is potentiated by the presence of the A allele at the -1540 locus.

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Four Polymorphisms ofVEGF(+405C>G, −460T>C, −2578C>A, and −1154G>A) in Susceptibility to Psoriasis: A Meta-Analysis

Cited by 21 publications

References 40 publications

Molecular regulation and role of angiogenesis in reproduction

Molecular regulation and role of angiogenesis in reproduction

Is the +405 G/C single nucleotide polymorphism of the vascular endothelial growth factor (VEGF) gene associated with late‐onset vitiligo?

Genetic Risk Factors for Psoriasis in Turkish Population: -1540 C/A, -1512 Ins18, and +405 C/G Polymorphisms within the Vascular Endothelial Growth Factor Gene

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