Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients

Luszczek, Wioleta; Kubicka, Wioletta; Cisło, M; Nockowski, Piotr; Mańczak, Maria; Woszczek, Grzegorz; Baran, Eugeniusz; Kuśnierczyk, Piotr

doi:10.1016/s0165-2478(02)00212-2

Cited by 29 publications

(32 citation statements)

References 26 publications

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“…KIR2DS1 is an activating receptor for group C2 molecules [11], including the HLA-Cw6 allele, which is known to be associated with psoriasis (see Introduction). HLA-Cw*06 was present in about 17% of the control subjects but in 77% of our patients (Table 3; pc Ͻ 0.00013), with the highest percentage of positives in the youngest age-at-onset group (Table 3; pc Ͻ 0.00013), as already reported [9]. Similarly, KIR2DS1 was much more frequent in patients (85%) than in controls (51%; pc Ͻ 0.00001), but in this case its frequency was not correlated with age at disease onset (Table 3).…”

Section: Onesupporting

confidence: 87%

“…HLA-C alleles were determined in 114 of the patients and the 123 control subjects using low-resolution PCR sequence-specific primer sets from Biotest, Dreieich, Germany, or Olerup, Oslo, Norway, as described previously [9]. Gel Electrophoresis PCR products were electrophoresed in 1.5% agarose gels containing 0.5 g/mL ethidium bromide.…”

Section: Polymerase Chain Reaction Detection Of Kir2dmentioning

confidence: 99%

“…The strongest genetic association was found with a major histocompatibility complex allele, HLA-Cw*06 [5][6][7], particularly in juvenile psoriasis [7][8][9]. Human leukocyte antigen (HLA)-C molecules are recognized by natural killer (NK) cell immunoglobulin-like receptors, KIR, encoded in the leukocyte receptor complex on chromosome 19q13.4 [10 -14], and fall into two groups differing in amino acid positions 77 and 80 in the ␣1 domain.…”

Section: Introductionmentioning

confidence: 99%

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Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris

et al. 2004

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Section: Onesupporting

confidence: 87%

Section: Polymerase Chain Reaction Detection Of Kir2dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris

et al. 2004

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“…According to the inclusion criteria, 18 studies with full-text were included in this meta-analysis (Rani et al, 1998;Gonzalez et al, 1999;Asumalahti et al, 2000;Brazzelli et al, 2000;Gudjonsson et al, 2003;Luszczek et al, 2003;Zhang et al, 2003;Sánchez et al, 2004;Martínez-Borra et al, 2003Holm et al, 2005a,b;Chang et al, 2004Chang et al, , 2005Chang et al, , 2006Płoski et al, 2006;Jobim et al, 2008;Fojtíková et al, 2009) and 127 studies were excluded. The flow chart for the study selection is summarized in Figure 1.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

Wu¹,

Wu²,

Liu³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a metaanalysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled odds ratio (OR) and 95% confidence interval (95%CI). We found significant associations between HLA-Cw*0602 polymorphism and psoriasis risk in the comparisons of positive versus negative alleles (OR = 4.55, 95%CI = 3.65-5.67, P < 0.00001); positive homozygote versus negative homozygote combined with heterozygote (OR = 14.00, 95%CI = 8.47-23.15, P < 0.00001); positive homozygote combined with heterozygote versus negative homozygote (OR = 5.11, 95%CI = 3.86-6.76, P < 0.00001); positive homozygote versus negative homozygote (OR = 23.03, 95%CI = 13.95-38.00, P < 0.00001), and positive homozygote versus heterozygote (OR = 4.21, 95%CI = 2.35-7.00, P < 0.00001). In conclusion, the positive allele of HLA-Cw*0602 polymorphism appears to be a risk factor for psoriasis.

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“…However, recent studies mainly investigating the association have discovered at least 9 bona fide risk loci for psoriasis in addition to HLA-Cw6 [15,16] (i.e. IL-12B, IL-23R, IL-23A [17,18,19,20], TNIP1, TNFAIP3 [17], IL-4/IL-13 [17], ZNF313 [21], DEFB4 [22], late cornified envelope region [23]).…”

Section: Introductionmentioning

confidence: 99%

The Association between the IL-20 –1723C→G Allele on the 1q Chromosome and Psoriasis Triggered or Exacerbated by an Upper Respiratory Tract Infection in the Chinese Han Population

Chen

Jin²,

Chen³

et al. 2010

Dermatology

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Background: Psoriasis is a cutaneous disorder of multifactorial etiology influenced by both genetic and environmental factors such as infection. Methods: We conducted a genome analysis with 20 microsatellite markers spanning the long arm of chromosome 1 in 36 Chinese families with psoriasis and detected evidence for linkage at 1q21 with a nonparametric linkage score of 1.74, p = 0.03, and 1q32 with one of 1.84, p = 0.03. According to the positional and functional candidate principle, we further investigated the single-nucleotide polymorphisms of the HAX-1 gene (located in 1q21) and IL-20 gene (located in 1q32) in a case-control study including 340 sporadic patients and 199 controls. Results: We determined that the frequency of the G allele of IL-20 –1723C→G (rs1713239) was significantly higher among psoriatic patients (38.5% in cases vs. 31.2% in controls, p = 0.015, odds ratio, OR = 1.39, 95% confidence interval, CI = 1.07–1.80). When we stratified our analysis by psoriasis triggered or exacerbated by infection of the upper respiratory tract, a significant difference was detected (42.4% in stratified cases vs. 31.2% in controls, p = 0.005, OR = 1.63, 95% CI = 1.15–2.30). Conclusion: We assume that triggered or exacerbated by respiratory tract infection, the population with the G allele of IL-20 –1723C→G are predisposed to psoriasis.

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Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients

Cited by 29 publications

References 26 publications

Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris

Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

The Association between the IL-20 –1723C→G Allele on the 1q Chromosome and Psoriasis Triggered or Exacerbated by an Upper Respiratory Tract Infection in the Chinese Han Population

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