Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.
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Densidade aparente dos resíduos da polpa de maracujáApparent density of passion fruit pulp residue
ResumoO objetivo do trabalho foi avaliar a densidade aparente dos componentes do resíduo da polpa de maracujá (arilo e sementes), tendo em vista um processo de separação física desses componentes. O resíduo foi suspenso em água e agitado a 1000 rpm por 60 min para separar os componentes, sendo secos em papel-toalha para realizar as medidas de densidade aparente pelo método do balão volumétrico, utilizando álcool etílico (96 °GL) para as sementes decantadas, e hexano para os materiais suspensos em água, com 10 repetições. A densidade aparente de sementes decantadas foi de 1160 kg m -3 ; o arilo apresentou 912 kg m -3 . As sementes suspensas de Padrão 1 (sementes imaturas finas e brancas) mediram 950 kg m -3 ; Padrão 2 (sementes claras e/ou com início de pigmentação escura) apresentaram 897 kg m -3 ; Padrão 3 (escuras) mediram 851 kg m -3 . Concluiu-se que a densidade aparente das sementes decantadas é maior do que a densidade da água, possibilitando o uso do processo de separação por decantação das sementes puras e o arraste do material suspenso, de densidade inferior à densidade da água. O processo de separação do arilo por meio da remoção de sementes em suspensão não pode ser realizado em meio aquoso.
Palavras-chave: Passiflora edulis Sims; Processamento de resíduos; Sementes; Arilo.
AbstractThe objective of this work was to evaluate the apparent density of the pulp residue components (aryl and seeds) aiming to develop a physical separation process for these components. The residue was suspended in water and stirred at 1000 rpm for 60 min to separate the components, which were then dried on paper towelling before carrying out the apparent density measurements using the volumetric balloon method with ethyl alcohol (96 °GL) for the decanted seeds, and hexane for the material suspended in the water, with 10 replicates. The apparent density of the decanted seeds was 1160 kg m -3 and that of the aryl 912 kg m -3 . The suspended seeds of Standard 1 (immature, fine, white seeds) measured 950 kg m -3 ; of Standard 2 (white and/or with the start of dark pigmentation) presented 897 kg m -3 ; and Standard 3 (dark seeds) measured 851 kg m -3 . It was concluded that the apparent density of the decanted seeds was higher than that of the water, making it possible to develop a physical process to separate pure decanted seeds and drag out the suspended material, which has a density lower than that of water. The process of separating the suspended seeds from the aryls cannot be carried out in an aqueous medium.
In general, the costs for cellulases production are associated with the value of the carbon source used in the process. Waste from the food processing industry contains several reusable substances that can replace the expensive components used in culture media for the production of cellulases. In this work, it was studied the combined interactive effect of different concentrations of sugarcane bagasse treated with alkali, passion fruit rind flour and corn steep liquor for maximal avicel -hydrolyzing enzymesavicelases by thermophilic Bacillus sp SMIA-2, using statistical methodology. The influence of metal ions on the activity and stability of the enzyme was also investigated in order to increase the industrial applicability of enzymes. A concentration of 0.3% (w /v) of these three components in the production medium can be used successfully to obtain high levels of avicellase activity. The avicelase displayed enhanced activity in the presence of 10 Mm CoCl2 after incubation at 90ºC for 1 h, indicating th at this enzyme depended on the metal ions to promote its activity and stability at higher temperatures.
The present study investigated the potential lipase production for Bacillus licheniformis SMIA-3 using the agro-industrial co-products: orange flour (OF) and grape flour (GF) blend waste cooking oil (WCO). The OF was selected due to its best source for lipase production observed in preliminary tests. Therefore, OF was tested at different fermentation times at 50°C using the statistical design Central Composite Rotatable Design (CCRD) allied to the response surface. An optimal region was found with lipolytic activity of 0.349 U mL-1 with OF and WCO filters around (0.50% w v-1) and between (0.55 and 0.75% w v-1), respectively, and the fermentation time at the central point (42h). Data supplied a method to produce lipase using orange flour and frying oil, as a way to reuse these waste as feedstock to obtain employable lipase and lower production costs with biotechnological applications in industrial sector
RESUMO-O ácido ɣ-poliglutâmico, ɣ-PGA, é um biopolímero biodegrável, hidrossolúvel, aniônico e atóxico, composto por unidades de D-e L-ácido glutâmico e possui aplicações nas áreas médica, química e de alimentos. Este trabalho teve como objetivo estudar a produção de ɣ-PGA por fermentação utilizando glicerol subproduto de biodiesel como fonte de carbono. O micro-organismo utilizado foi o Bacillus velezensis NRRL B-23189 e a produção de ɣ-PGA ocorreu sem adição de ácido glutâmico ao meio de cultura. Foram estudadas diferentes concentrações de glicerol, ácido cítrico e sulfato de amônio. A avaliação das condições de cultivo foi feita com agitação de 200 rpm, temperatura de 27 ºC, pH inicial de 6,5 (ajustado com NaOH 2N/HCl 2N) durante 72 h mediante delineamento composto central rotacional (DCCR). Para a avaliação da produção de ɣ-PGA foi utilizada uma metodologia de quantificação via espectrofotometria a 400 nm. A máxima produção de ɣ-PGA em meio contendo 100 g/L de glicerol foi de 4,17 g/L.
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