A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for drugs which alter anxiety-like behavior in adult zebrafish. The observed phenotypes were clustered according to shared behavioral effects. This barcoding procedure revealed conserved functions of anxiolytic, anxiogenic and psychomotor stimulating drugs and predicted effects of poorly characterized compounds on anxiety. Moreover, anxiolytic drugs all decreased, while anxiogenic drugs increased, serotonin turnover. These results underscore the power of behavioral profiling in adult zebrafish as an approach which combines throughput and physiological complexity in the pharmacological dissection of complex behaviors.
Resumo:A água é o recurso natural mais importante do planeta, e encontra-se suscetível às alterações causadas por contaminantes biológicos e químicos, podendo causar doenças tanto no homem, como em animais. Este trabalho objetivou quantificar pesquisas bibliográficas referentes à qualidade físico-química e microbiológica da água destinada ao consumo humano e animal, afim de analisar se estão dentro dos padrões exigidos pelas legislações vigentes. As pesquisas foram realizadas em duas bases de dados científicas, a Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) e o Scientific Electronic Library Online (SciELO). A quantificação dos dados partiu da análise de 7.865 artigos, destes, 27 foram selecionados pela leitura dos títulos, sendo que 8 eram repetições, restando 19 produções. Em seguida, fez-se a leitura dos resumos, restando 11 artigos e por fim, selecionou-se 8 de interesse. Por meio dos artigos analisados, pode-se perceber que existem poucas pesquisas em relação a qualidade físico-química e microbiológica das águas destinadas ao consumo humano e, principalmente, animal. A partir desta investigação, conclui-se que a maioria dos valores das águas brasileiras analisadas encontravam-se fora do qual é estipulado pelas Resoluções e Portarias vigentes.
Palavras-chave:Microrganismos. Água potável. Dessedentação animal.
Financial analysis of investments in forest concession for amazon brazilian by deterministic and stochastic methods. CERNE, v. 25, n. 4, p.482-490, 2019. HIGHLIGHTS The forest concession must have a minimum productivity of 17.75 m³. ha-1 .
Background:The digital infrared imaging thermography is a non-invasive imaging exam of easy performance accurately to measure temperatures of the areas of the animals body. The objective was to study the physiological variations of the surface temperature of the mammary gland, vulva, pelvis, thorax and abdomen with digital infrared imaging thermography in negative dairy cattle with California mastitis test (CMT) in different seasons, and the influence of climatic factors in these temperatures.
Length-weight relationships (LWR) of 14 fish species were estimated from Palito Mountain ridge, upper Tapajós river basin, Brazilian Amazon region. This study represents the first LWR to the small characid Hemigrammus marginatus, and additionally provides new maximum record of length and weight for three species.
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