BK virus (BKV) infection occurs most often in immunocompromised hosts, in the setting of renal or bone marrow transplantation. Hemorrhagic cystitis is the commonest manifestation but in recent years infections in other organ systems have been reported. We report an unusual case of biopsy-proven BKV encephalitis in a hematopoietic stem cell transplant patient who subsequently developed thrombotic microangiopathy. As far as we know, this is the first report of such an association in a transplant patient.
Introduction. Arbutus unedo L. (strawberry-tree fruit) is indigenous plant in North Africa with few published works about the composition of its fruits. For their valorization, morphological and chemical characterizations were carried out for two harvesting seasons of four different areas of Algeria. Materials and methods. Wild strawberry-tree fruits were collected in four different sites located in Tell Atlas, and two different seasons. Fruit size and shape, pH, titratable acidity, moisture, total available carbohydrate (TAC), soluble sugars, dietary fiber, protein, lipid, ash, fatty acids and mineral composition (K, Na, Ca, Mg, Fe, Cu, Mn, Zn, Ni and Cd) were determined. Results and discussion. Fruit contents (in g kg −1) varied between 637.3 ± 33.8 to 741.3 ±12.0, 126.8 ± 11.1 to 189.3 ± 4.1, 22.6 ± 2.2 to 35.5 ± 2.1, 5.1 ± 0.3 to 8.8 ± 0.5 for moisture, TAC, protein and lipid, respectively. For iron, fruit weight and polyunsaturated fatty acids (PUFA), the contents varied between 7.01 ± 0.15 to 17.24 ± 0.74 mg kg −1 of fruit, 4.91 ± 1.58 to 6.76 ± 2.04 g and 56.34 ± 1.37 to 68.18 ± 0.14% of lipid, respectively. Conclusion. This study provides original data about the morphological and chemical composition of strawberry-tree fruits from Algeria. The results show that the fruits can be essentially a potential source of dietary fiber, PUFA and iron.
The objectives were to conduct a genetic evaluation of residual feed intake (RFI) and residual feed intake adjusted for fat (RFIFat) and to analyse the effect of selection for these traits on growth, carcass and reproductive traits. Data from 945 Nellore bulls in seven feed efficiency tests in a feedlot were analysed. Genetic evaluation was performed using an animal model in which the feed efficiency test and age of the animal at the beginning of the test were considered as a systematic effect. Direct additive genetic and residual effects were considered as random effects. Correlations and genetic gains were estimated by two-trait analysis between feed efficiency measures (RFI and RFIFat) and other traits. Feed conversion showed low heritability (0.06), but dry matter intake (DMI), average daily gain, RFI, RFIFat, metabolic body weight and scrotal circumference measured at 450 days of age (SC450) showed moderate to high heritability (0.49, 0.28, 0.33, 0.36, 0.38 and 0.80, respectively). Similarly, ribeye area, backfat thickness, rump cap fat thickness, marbling score and subcutaneous fat thickness also had high heritability values (0.46, 0.37, 0.57, 0.51 and 0.47, respectively). Genetic correlations between RFI and SC450 were null, and between RFIFat and SC450 were strongly positive. Genetic and phenotypic correlations of RFI and RFIFat with carcass traits were not different from zero, as correlated responses for carcass traits were also not different from zero. The Nellore selection for feed efficiency by RFI or RFIFat allows the recognition of feed efficient animals, with DMI reduction and without significant changes in growth and carcass traits. However, because of the observed results between RFIFat and SC450, selection of animals should be analysed with caution and a preselection for reproductive traits is necessary to avoid reproductive impairments in the herd. K E Y W O R D S Bos taurus indicus, carcass traits, genetic parameters, performance test, residual feed intake | 465 MORAES Et Al. How to cite this article: Moraes GF, Abreu LRA, Toral FLB, et al. Selection for feed efficiency does not change the selection for growth and carcass traits in Nellore cattle. J Anim Breed Genet. 2019;136:464-473. https ://doi.
RESUMODados de peso de animais da raça Nelore de 90 a 450 dias de idade das regiões Sudeste (SE) e Centro-Oeste (CO) do Brasil foram utilizados para comparar estruturas de (co)variância de efeitos aleatórios em função de idade estimadas para as duas regiões por meio de modelos de regressão aleatória. Componentes de (co)variância referentes aos coeficientes de regressão aleatória foram estimados por EMREML por meio do programa REMLF90. Os efeitos fixos de grupo contemporâneo e os efeitos aleatórios genético aditivo direto, genético aditivo materno e permanente de ambiente foram modelados por polinômios quadráticos de Legendre. As comparações envolveram estruturas de covariância e de correlação dos efeitos aleatórios, herdabilidades direta e materna e a razão entre variâncias genéticas de diferentes regiões. As herdabilidades e estruturas de covariância e de correlação apresentaram comportamento semelhante nas duas regiões. A variância residual e as variâncias de efeito permanente de ambiente foram menores no CO, bem como a variância genética aditiva materna dos 150 aos 400 dias de idade. Trajetórias dos efeitos fixos em função de idade de diferentes grupos contemporâneos apresentaram diferentes formas, sugerindo a necessidade de estimar um conjunto de coeficientes de regressão específico para cada grupo contemporâneo. A variância do efeito genético aditivo materno apresentou maior heterogeneidade entre regiões do que a variância genética aditiva direta. Palavras
RESUMODados de pesos aos 205 (P205) e 365 (P365) dias de idade, de 28.946 animais Tabapuã, provenientes de 152 fazendas dos diversos estados brasileiros, nascidos no período de 1976 a 1995, foram utilizados nesta análise. Foram avaliadas as interações genótipo-ambiente, bem como estimadas herdabilidades direta e materna pelo método de máxima verossimilhança restrita em modelo estatístico, que incluiu efeitos fixos de grupo contemporâneo, idade da vaca ao parto (covariável) e efeitos aleatórios genéticos direto e materno. As estimativas de herdabilidade direta e materna para P205 nas regiões Sul (R1), Sudeste (R2), Centro-Oeste (R3) e Nordeste (R4) foram: 0,02 e 0,31 (R1), 0,17 e 0,19 (R2), 0,20 e 0,09 (R3) e 0,06 e 0,16 (R4). Para P365, foram 0,05 e 0,03 (R1), 0,20 e 0,03 (R2), 0,51 e 0,62 (R3) e 0,15 e 0,05 (R4). As correlações genéticas encontradas para as características P205 e P365, ambas consideradas características distintas nas regiões R1, R2, R3 e R4, foram: 1,00 e 0,99, 0,84 e 0,99, -0,86 e -0,73, 0,98 e 0,93, 0,51 e 0,45, 1,00 e 0,12 para R1/R2, R1/R3, R1/R4, R2/R3, R2/R4 e R3/R4, respectivamente. Esses resultados indicam que, na desmama (P205), o efeito da interação genótipo x ambiente foi observado somente nas combinações que envolveram a região Nordeste (R4) e as regiões Sul (R1) e Sudeste (R2). Para pesos pós-desmama (P365), o efeito dessa interação foi evidenciado em todas as combinações que incluíram a região Nordeste.Palavras-chave: bovino, Tabapuã, característica ponderal, herdabilidade direta e materna, interação genótipo-ambiente ABSTRACT
Summary:A 30-year-old woman developed veno-occlusive disease of the liver during an allogeneic BMT for acute leukemia. Treatment with recombinant human tissue plasminogen activator and heparin resulted in an incomplete and transient response followed by progressive disease. The patient was then given defibrotide (DF), a mammalian tissue-derived polydeoxyribonucleotide developed for the treatment of a number of vascular disorders, which has thrombolytic and anti-thrombotic properties. No significant bleeding or other major toxicities were observed during treatment and she made a full recovery. At 6 months after the onset of VOD her liver function tests and color flow Doppler ultrasound scan are normal. Our experience supports the preliminary results already obtained with DF. Its efficacy should be evaluated in a prospective randomized fashion.
RESUMO -O objetivo deste trabalho foi analisar a pele de três espécies de peixes (piavuçu Leporinus macrocephalus, pacu prata Mylossoma sp e piraputanga Brycon hilarii) através de análise histologica e morfometrica e testes de resistência após o curtimento. Amostras de peles da região dorsal foram coletadas, fixadas em Bouin por 24 horas, incluídas em parafina, cortadas em 5 µm de espessura e coradas por Hematoxilina-eosina. Os cortes foram analisados pela microscopia de luz. Foi utilizado o dinamômetro EMIC para a análise físico-mecânica do couro em 10 amostras no sentido longitudinal a partir da região dorsal do peixe de cada espécie. A derme desses peixes possui um padrão estrutural comum aos teleósteos, porém a disposição e distribuição das fibras colágenas apresentaram-se diferentes entre as espécies analisadas. Através da análise morfométrica constatou-se que a espessura da derme da pele diferiu entre as três espécies. Não houve diferença no teste de resistência à tração no couro da piraputanga (16,88 N/mm 2 ) e piavuçu (18,50 N/mm 2 ). Os resultados para os couros destas duas espécies de peixes foram superiores ao pacu (11,83 N/mm 2 ). O valor de alongamento até a ruptura foi superior para piavuçu (52,83%) e piraputanga (60,45%), não diferindo entre eles, porém foi inferior para o pacu (33,83%). O rasgamento progressivo foi maior no couro de pacu (36,51 N/mm). As peles das três espécies analisadas podem ser transformadas em couro para sua aplicação em diversos artefatos.Palavras-chave: derme, resistência, fibras colágenas, histologia, morfometria, testes físico-mecânicos Analysis of the Skin of Three Fish Species: Histology, Morphometry and Resistance TestsABSTRACT -This study was carried out to analyse the skin of three species of fish (piavuçu Leporinus macrocephalus, pacu prata Mylossoma sp e piraputanga Brycon hilarii) through histological and morphometrical analysis and resistance tests after hardening. Skin samples from the dorsal region were taken and fixed in Bouin solution for 24 hours. They were embedded in paraffin, cut 5 µm thick and stained by Hematoxylin-eosin technique. The cuts were analyzed by light microscopy. A EMIC dynamometer was used for the physical mechanical analysis of the skin in 10 samples, longitudinally oriented from the dorsal region of each specie of fish. The dermis of those fishes has a structural pattern common to teleosts, but the setting and distribution of collagen fibers was different among the analyzed species. The skin dermis thickness differed among the three species by the morphometrical analysis. No difference was observed for the resistance test to traction in piraputanga leather (16.88 N/mm 2 ) as well as in piavuçu leather (18.50 N/mm 2 ). The results for the skin of both fish species were higher than those for pacu (11.83 N/mm 2 ). The value of stretching as to the point of rupture was higher for piavuçu (52.83%) and piraputanga (60.45%), showing no difference among them, but it was lower for pacu (33.83%). The progressive tearing was greater in pacu ski...
RESUMOO desempenho de 149 animais, machos inteiros, confinados por períodos variáveis de acordo com acabamento de carcaça, foi utilizado para avaliar a eficiência econômica dos grupos genéticos Nelore sobreano, Nelore desmamado, ½ Valdostana ½ Nelore, ½ Simental ½ Nelore, ½ Braford ½ Brangus, ½ Nellore (0.79) and Brangus (0.82). The highest gross margin was obtained for yearling Nellore (94.6), followed by Brangus (71.5) and ½ Simmental ½ Nellore (46.6) The heaviest genetic groups in the beginning of the feed lot were confined for shorter periods and had the largest gross margins.
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