Our SEDAN score reliably assessed risk for sICH in IV thrombolysis-treated patients with anterior- and posterior circulation ischemic stroke, and it can support clinical decision making in high-risk patients. External validation of the score supports its generalization.

Risk index was significantly higher in the presence of symptoms and could therefore be a valuable tool to assess the clinical risk of a carotid plaque.

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Conclusion:A new ultrasound risk index parallels the presence of symptoms and may be a means of assessing the clinical risk of a carotid plaque.Summary: Thus far, prophylactic intervention for carotid artery stenosis is determined primarily by the severity of the degree of the stenosis. However, stenosis severity itself in asymptomatic patients is relatively insensitive in determining which patients develop neurologic symptoms. Additional variables, such as plaque morphology, may also play an important role in occurrence of cerebrovascular events and may be predictors of ipsilateral stoke that act independently or in concert with the degree of stenosis. The authors developed an ultrasound risk index (RI) based on the combination of degree of stenosis and echogenicity of the plaque surface. In this study, the aim was to evaluate the accuracy of the RI in a cohort of consecutive patients presenting with symptomatic or asymptomatic carotid stenosis. In addition, the authors wished to compare this method with other wellestablished parameters, including degree of stenosis alone and gray-scale median of the plaque, for predicting potential neurologic events associated with carotid stenosis. The authors used consecutive patients with 50% to 99% internal carotid stenosis. Semi-automated gray scale-based color mapping (red, yellow, and green) of the whole plaque and of its surface was preformed. The surface was defined as the region located between the lumen (level 0) and, respectively, 0.5, 1, 1.5, and 2 mm below the surface. RI was based on the combination of the degree of stenosis and the proportion of red color (indicating low echogenicity) on the surface or in the whole plaque. There were 67 symptomatic and 117 asymptomatic carotid stenoses analyzed. RI values were higher among symptomatic lesions (0.46 vs 0.29; P Ͻ .001). Using receiver operating characteristic curves, RI had stronger predictive value compared with degree of stenosis or surface echogenicity alone. In a regression model that included age, gender, degree of stenosis, surface echogenicity, gray-scale median of the whole plaque, and RI, RI measured within the surface region (0.5 mm from the lumen) was the only parameter significantly associated with the presence of symptoms (odds ratio, 4.89; 95% confidence interval, 2.7-8.7; P ϭ .0000002). RI was also the best criteria to differentiate between symptomatic and asymptomatic stenosis (RI value Ͻ0.36, sensitivity 78% and specificity 65%).Comment: These authors studied many different parameters to predict symptoms associated with carotid plaque, including age, gender, degree of stenosis, surface echogenicity, gray-scale median of the whole plaque, and RI. Of all these parameters, it is intriguing that only RI measured within the surface region located 0.5 mm from the lumen was significantly associated with the presence of symptoms. Unfortunately, the authors' RI, while an intriguing new ultrasound parameter, appears somewhat difficult to calculate, and it is unknown if the data are reproducible among differ...

No abstract

Cerebral venous thrombosis (CVT) has usually been ascribed to prothrombotic conditions, oral contraceptives, pregnancy, malignancy, infection, head injury or mechanical precipitants. The case reported here illustrates two rare causes of CVT observed in the same patient: the presence of antiphospholipid antibodies associated with an asymptomatic cryptogenic organising pneumopathy (COP) which were considered the origin of the venous cerebral thrombosis and heparin-induced thrombocytopenia (HIT) which was responsible for the worsening of the thrombosis observed a few days after the introduction of treatment. Moreover, we provide here additional positive experience in the treatment of both, CVT and HIT, by fondaparinux with bridging to warfarin given their successful evolution under this anticoagulant option.

The early and proper diagnosis of nonmetastatic choriocarcinoma of nongestational origine in coexistence with cervical carcinoma is curable and can have good prognosis.

Cervical cancer incidence and mortality rates in Serbia are among the highest in Europe and data on Human papilloma virus (HPV) type distribution are scarce. The aim of this study was to determine the prevalence of HPV types in archival specimens of cervical cancer tissues of women in the Serbian population. A total of 45 paraffin-embedded tissue samples of cervical carcinoma were used in this study. The procedure included deparaffinization of tissue samples, DNA extraction, PCR, gel electrophoresis and HPV genotyping by direct sequencing. HPV was detected in 32 samples (71%). Genotyping revealed the presence of 6 high-risk HPV types 16, 18, 33, 45, 53 and 58, where HPV type 16 was the most prevalent type (73.7%). The results of this study and further studies will provide more detailed information about HPV genotype distribution and may contribute to the formulation of national guidelines for the prevention of cervical cancer. [175073]