Contrast-Enhanced Ultrasound Imaging of Carotid Plaque Neo-vascularization: Accuracy of Visual Analysis

Muller, H; Viaccoz, Aurélien; Kuzmanovic, I; Bonvin, Christophe; Burkhardt, Karim; Bochaton‐Piallat, Marie‐Luce; Sztajzel, Roman

doi:10.1016/j.ultrasmedbio.2013.08.012

Cited by 21 publications

(13 citation statements)

References 21 publications

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“…Previous studies have shown that the temporal parameter EI is correlated with the histological MVD, 2,16 and this study confirms the reliability of the correlation. Furthermore, it has been shown that EIR, another temporal parameter that agrees with visual grading on CEUS, 5 is also correlated with MVD (r ¼ .75; Table 1).…”

Section: Discussionsupporting

confidence: 88%

“…2,6,16,17 Thus, it is speculated that correlations may also exist between spatial and temporal parameters. Here, correlations between the two types of parameters are reported for the first time.…”

Section: Discussionmentioning

confidence: 99%

“…2,5,6,12,18 These contradictory outcomes suggest that further studies on large populations should be conducted to elucidate the association.…”

Section: Discussionmentioning

confidence: 99%

“…Grade 1 indicated no appearance of moving microbubbles in the plaque or bubbles confined only to the adjacent adventitial layer; grade 2 was reserved for images with a moderate visible appearance of moving bubbles in the plaque at the adventitial side or plaque shoulder; and grade 3 indicated extensive IPN, with a clearly visible appearance of bubbles moving to the plaque core. 1,2,4,7 The cases in which there was disagreement between investigators were discussed jointly in order to reach a consensus.…”

Section: Semiquantitative Visual Interpretation On Ceusmentioning

confidence: 99%

“…1 Assessment of IPN on CEUS is frequently performed by visual grading of IPN. 1,2 However, visual assessment is a means of semiquantitative measurement that is highly user dependent, and different studies use different scoring scales. Thus, it is difficult to use the visual assessment as a diagnostic tool.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Spatio-temporal Quantification of Carotid Plaque Neovascularization on Contrast Enhanced Ultrasound: Correlation with Visual Grading and Histopathology

Zhang

Han

et al. 2015

European Journal of Vascular and Endovascular Surgery

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

“…2,5,6,12,18 These contradictory outcomes suggest that further studies on large populations should be conducted to elucidate the association.…”

Section: Discussionmentioning

confidence: 99%

Section: Semiquantitative Visual Interpretation On Ceusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Spatio-temporal Quantification of Carotid Plaque Neovascularization on Contrast Enhanced Ultrasound: Correlation with Visual Grading and Histopathology

Zhang

Han

et al. 2015

European Journal of Vascular and Endovascular Surgery

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Contrast-enhanced ultrasound: clinical applications in patients with atherosclerosis

Schinkel

Kaspar

Staub

2015

Int J Cardiovasc Imaging

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Contrast-enhanced ultrasound (CEUS) is increasingly being used to evaluate patients with known or suspected atherosclerosis. The administration of a microbubble contrast agent in conjunction with ultrasound results in an improved image quality and provides information that cannot be assessed with standard B-mode ultrasound. CEUS is a high-resolution, noninvasive imaging modality, which is safe and may benefit patients with coronary, carotid, or aortic atherosclerosis. CEUS allows a reliable assessment of endocardial borders, left ventricular function, intracardiac thrombus and myocardial perfusion. CEUS results in an improved detection of carotid atherosclerosis, and allows assessment of high-risk plaque characteristics including intraplaque vascularization, and ulceration. CEUS provides real-time bedside information in patients with a suspected or known abdominal aortic aneurysm or aortic dissection. The absence of ionizing radiation and safety of the contrast agent allow repetitive imaging which is particularly useful in the follow-up of patients after endovascular aneurysm repair. New developments in CEUS-based molecular imaging will improve the understanding of the pathophysiology of atherosclerosis and may in the future allow to image and directly treat cardiovascular diseases (theragnostic CEUS). Familiarity with the strengths and limitations of CEUS may have a major impact on the management of patients with atherosclerosis.

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Correlation of enhancement degree on contrast-enhanced ultrasound with histopathology of carotid plaques and serum high sensitive C-reactive protein levels in patients undergoing carotid endarterectomy

Xiong

Sun

Cai

et al. 2017

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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This study was undertaken to investigate the correlation of the enhancement degree on contrast-enhanced ultrasound (CEUS) with the histopathology of carotid plaques and the serum high sensitive C-reactive protein (hs-CRP) levels in patients undergoing carotid endarterectomy (CEA). Carotid CEUS was performed preoperatively in 115 patients who would undergo CEA, and the enhancement degree of the carotid plaques was evaluated by both the visual semiquantitative analysis and the quantitative time-intensity curve analysis. Serum hs-CRP levels were detected using the particle-enhanced immunoturbidimetric assay also before the operation. Additionally, the carotid plaque samples were subjected to histopathological examination postoperatively. The density of neovessels and the number of macrophages in the plaques were assessed by immunohistochemistry. The results showed that among the 115 patients, grade 0 plaque contrast enhancement was noted in 35 patients, grade 1 in 48 patients and grade 2 in 32 patients. The degree of plaque enhancement, the density of neovessels, the number of macrophages, and the hs-CRP levels were highest in the grade 2 patients. Correlation analysis showed that the enhancement degree of the carotid plaques was closely related to the immunohistochemical parameters of the plaques and the serum hs-CRP levels. It was suggested that the carotid plaque enhancement on CEUS can be used to evaluate the vulnerability of carotid plaques.

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Contrast-Enhanced Ultrasound Imaging of Carotid Plaque Neo-vascularization: Accuracy of Visual Analysis

Cited by 21 publications

References 21 publications

Spatio-temporal Quantification of Carotid Plaque Neovascularization on Contrast Enhanced Ultrasound: Correlation with Visual Grading and Histopathology

Spatio-temporal Quantification of Carotid Plaque Neovascularization on Contrast Enhanced Ultrasound: Correlation with Visual Grading and Histopathology

Contrast-enhanced ultrasound: clinical applications in patients with atherosclerosis

Correlation of enhancement degree on contrast-enhanced ultrasound with histopathology of carotid plaques and serum high sensitive C-reactive protein levels in patients undergoing carotid endarterectomy

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