Cervical poorly differentiated adenocarcinoma with dominant choriocarcinomatous pattern: A case report

Bonaci-Nikolic, Branka; Curkovic, Aleksandar; Dikić, Svetlana Dragojević; Mitrović, Ana; Kuzmanovic, I; Arandjelović, Aleksandra; Stanković, Goran

doi:10.2298/vsp141004041n

Cited by 3 publications

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References 3 publications

(12 reference statements)

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“…Serum value of human chorionic gonadotropin is the most relevant parameter in diagnosis of GTN. It depends on secretion of syncytiotrophoblast which is a hormone active component of trophoblast, and most important marker in monitoring the effect of the treatment and outcome of the disease 4 . In placental site trophoblastic tumor (PSTT), serum levels of chorionic gonadotropin do not have the same significance as they do in other malignant GTN, and they may be negative, making this analysis unuseful.…”

Section: Introductionmentioning

confidence: 99%

Malignant postpartal gestational trophoblastic neoplasm: A rare appearance of equal ultrasonography and operative finding in uterine placental site trophoblastic tumor and choriocarcinoma

Kosta

Mihajlovic

Ivic³

et al. 2020

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Introducton. Frequency of malignant gestational trophoblastic neoplasms (GTN) is estimated at 1.03 cases in 1,000 deliveries with 5 fold greater risk in patients younger than 20 and older than 40 years. Serum value of human chorionic gonadotropin is the most relevant parameter in diagnosis of GTN. In placental site trophoblastic tumor (PSTT), serum levels of chorionic gonadotropin do not have the same significance as they do in other malignant GTN. Definite diagnosis of PSTT is almost always confirmed by immunohistochemistry. Case report. In the course of just a few months (August 2016 to January 2017) in the Clinic for Obstetrics and Gynecology ?Narodni front? in Belgrade, two GTN patients were admitted and treated, with almost equal ultrasonography (pictures), operative findings and postoperative outcome. Due to histopathological and immunohistochemical examinations two different types of malignant GTN were confirmed. The first patient (admitted in August 2016), 26 years old, was admitted for uterine bleeding 11 months after vaginal delivery and histopathological examination confirmed PSTT. The second patient (admitted in January 2017), 27 years old, was admitted 4 months after vaginal delivery because of uterine bleeding. Histopathological examination confirmed choriocarcinoma. Conclusion. Considering the fact that malignant GTN can appear in different types, with different ultrasonography pictures, this report is significant because two distinctly different malignant GTN entities could appear with equal clinical manifestations and equal ultrasound pictures even when they may have very different course of the disease treatment and outcome. Such cases need correct diagnosis which may be reached only after immunohistochemical analysis. The ultrasound patterns, both in gray scale, color flow, and Doppler values, were almost equal in both cases and guided the diagnostic procedures to the final treatment, even regardless of their very different histopathology.

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Section: Introductionmentioning

confidence: 99%

Malignant postpartal gestational trophoblastic neoplasm: A rare appearance of equal ultrasonography and operative finding in uterine placental site trophoblastic tumor and choriocarcinoma

Kosta

Mihajlovic

Ivic³

et al. 2020

VOJNOSANIT PREGL

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“…A term ETT was proposed in 1994 for the first time when it was thought that this kind of tumor occurred as a consequence of administering chemotherapy in the patients with choriocarcinoma, i.e., that chemotherapy influenced the tumor growth by mechanism of drug induced cell changes. In 1998 study by Shih and Kurman 1 , it was shown that ЕТТ became an independent entity because it has for some specific histological and immunohistochemical features which make it different from placental site tumor and choriocarcinoma [1][2][3] . ЕТТ origins from intermediate trophoblast and it can overlap with squamous cell carcinoma as per differential diagnosis considering its common localization in the lower uterine segment or cervix when some cases of ETT were noted in oviducts and ligamenta lata 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Fatal outcome in the patient with the suspected ectopic pregnancy and diagnosed epithelioid trophoblastic tumor

et al. 2019

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Introduction. Epithelioid trophoblastic tumor (E??) is an extremely rare form and unusual type of trophoblastic tumor. In 1998 ??? became an independent entity because it possesses specific histological and immunohistochemical features which make it different from placental site tumor and choriocarcinoma. ??? origins from intermediate trophoblast and it can overlap with the squamous cell carcinoma as per differential diagnosis. The relevant literature data suggest that surgical treatment is a treatment of choice for ETT considering that its response to chemotherapy is considerably poor. Case report. A 35-years-old patient G3 P2 came to an examination due to the low pelvic pain and absence of menstrual cycle. She reported that menstrual cycles were irregular during the past year. During the bimanual pelvic examination, a painful tumefaction being approximately 8 cm was palpated in the pouch of Douglas. The patient was operated on as being suspected for ectopic pregnancy when it was noticed that the aforementioned tumefaction was located retroperitoneally immediately against rectosigmoid part of the colon. After the histopathological analysis of the sample, in order to make the final diagnosis, the immunohistochemical test was performed and it found that this E??. Due to an inadequate response to administered chemotherapy, both resection of rectosigmoid colon with appurtenant tumor and left hepatectomy with salpingectomy on both sides were performed considering a possibility of gestational trophoblastic neoplasia (GTN) after ectopic pregnancy. Because of dehiscence of colorectal anastomosis, relaparotomy with colostomy bag fitting was performed. The patient died on the day 40 after surgical treatment due to hepatic insufficiency. Conclusion. In order to make as much adequate treatment method of ETT as possible, it is necessary to organize a team work with multidisciplinary approach. Surgical resection of the tumor is a primary method for treating ETT.

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Hormone producing gynecological tumors: pathologic entities and clinical significance

Boto

Hui

2017

Expert Review of Endocrinology & Metabolism

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Due to their derivation from the cell types involved in gynecologic hormonal networks, many gynecologic tumors may produce hormones. In a normal physiological setting, these hormones are essential for regulating the biology and function of gynecological organs, the ovary and uterus in particular. Overproduction of hormones by the tumor may lead to abnormal clinical manifestations of the patients and spillage of excess hormonal products into the blood. Abnormal elevation of serum hormones may be considered as biomarkers that are important to pathologists and clinicians in making precise tumor diagnoses and likely useful in monitoring the tumor burden/recurrence to guide patient treatment options. This review will discuss gynecologic neoplasms that produce hormonal biomarkers and assess their relevance to pathological diagnosis, evaluation for therapeutic response and monitoring disease progression. Areas covered: Studies involving hormonal production by a gynecologic tumor were candidates for inclusion in this review. Expert commentary: Serum hormonal biomarkers have clinical utility both in the diagnosis of gynecologic neoplasms and clinical monitoring of treatment efficacy and recurrence.

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Cervical poorly differentiated adenocarcinoma with dominant choriocarcinomatous pattern: A case report

Abstract: The early and proper diagnosis of nonmetastatic choriocarcinoma of nongestational origine in coexistence with cervical carcinoma is curable and can have good prognosis.

Cited by 3 publications

References 3 publications

Malignant postpartal gestational trophoblastic neoplasm: A rare appearance of equal ultrasonography and operative finding in uterine placental site trophoblastic tumor and choriocarcinoma

Malignant postpartal gestational trophoblastic neoplasm: A rare appearance of equal ultrasonography and operative finding in uterine placental site trophoblastic tumor and choriocarcinoma

Fatal outcome in the patient with the suspected ectopic pregnancy and diagnosed epithelioid trophoblastic tumor

Hormone producing gynecological tumors: pathologic entities and clinical significance

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