As the Higgs boson could be a key to unlocking mysteries regarding our Universe, melatonin, a somewhat mysterious substance secreted by the pineal gland primarily at night, might be a crucial factor in regulating numerous processes in human reproduction. Melatonin is a powerful antioxidant which has an essential role in controlling several physiological reactions, as well as biological rhythms throughout human reproductive life. Melatonin, which is referred to as a hormone, but also as an autocoid, a chronobiotic, a hypnotic, an immunomodulator and a biological modifier, plays a crucial part in establishing homeostatic, neurohumoral balance and circadian rhythm in the body through synergic actions with other hormones and neuropeptides. This paper aims to analyze the effects of melatonin on the reproductive function, as well as to shed light on immunological and oncostatic properties of one of the most powerful hormones.
Study of ion beam transport from the SECRAL electron cyclotron resonance ion source at the Institute of Modern Physicsa) Rev. Sci. Instrum. 83, 02B726 (2012); 10.1063/1.3680545 Experiments and modification on electron cyclotron resonance ion sources at the Institute of Modern Physics Rev. Sci. Instrum. 77, 03A308 (2006); 10.1063/1.2162849 Multiply charged ion-induced secondary electron emission from metals relevant for laser ion source beam diagnostics Rev. Sci. Instrum. 73, 776 (2002);This article describes the L3A experimental facility for surface modification of materials at the Vinča Institute of Nuclear Sciences, in Belgrade. This facility was completed and put into operation in May 1998. It is connected to the mVINIS ion source, an electron cyclotron resonance ion source capable of producing a wide range of multiply charged ions from gaseous and solid substances. The heavy ion beams obtained from mVINIS are separated by charge to mass ratio (q/m) and transported to the target chamber for sample irradiation and modification. The target chamber is equipped with a multipurpose target holder, an electron-beam evaporation source for thin layer deposition, a residual gas analyzer, and other auxiliary equipment. There is also an additional low energy argon ion source for target preparation/sputtering and for ion beam assisted deposition. In this article we describe the layout and performances of the L3A facility, the experience gained during 1 yr of operation, and the requirements imposed by the current and future experimental programs. Currently, there are 24 experimental programs competing for the ion beam time at the L3A facility.
Ultrasonography BI-RADS improved classification of breast masses. The ultrasound BI-RADS 4 (A, B, C) and BI-RADS 5 lesions should be worked-up with biopsy.
The mVINIS ion source is a multiply charged heavy ion source based on the electron cyclotron resonance effect. This machine is a part of the Tesla Accelerator Installation, an ion accelerator facility whose construction has been going on at the VINČA Institute of Nuclear Sciences in Belgrade, Yugoslavia. mVINIS is an advanced version of the Dubna electron cyclotron resonance ion source 14-2, constructed at the Joint Institute for Nuclear Research (JINR) in Dubna, Russia. It is a complete injector, consisting of an ECR ion source, focusing and steering elements, an analyzing magnet, a vacuum system, and an ion beam diagnostic system. The main parts of mVINIS have been designed and manufactured at JINR, while the vacuum equipment, power supplies, ion beam diagnostics, and control system were purchased elsewhere. The preliminary testing (magnetic field measurements, vacuum testing, testing of the ECR ion source) has been performed at JINR, and the final assembly of the mVINIS and measurement of the ion beam parameters have been going on at the VINČA Institute.
Objectives: The purpose of this study was to examine the potential impact of severe Ovarian hyper stimulation syndrome (OHSS) on the risk of preterm birth. Severe ovarian hyperstimulation syndrome is a serious complication in the methods of in vitro fertilization. The pathophysiology of this process is not clear enough and the treatment is symptomatic. Human chorionic gonadotropin (h-CG) is the most important known cause of this condition. Findings of other authors often do not match when it comes to complications that may occur in pregnancy. Methods: In the Gynecology and Obstetrics Clinic “Narodni Front” a case control study was conducted on 50 female patients with severe forms of OHSS in the period from January 2008 to March 2015. A control group was created based on age and it involved 59 patients with pregnancy achieved with IVF/ICSI during the same period, but in which OHSS did not occur. Results: Patients with the pregnancy complicated by OHSS, had a considerably higher rate of preterm labor, whether this was labor before gestation week 37 (56.0% vs. 30.5%) or before gestation week 34 (34.0% vs. 6.8%); significantly lower weight of newborns, as in the newborns with low body weight <2500g (45.6% vs. 25.0%) and specially in the newborn with very low body weight <1500 grams (19.1% vs. 3.8%), as well as preterm premature rupture of membranes (PPROM), (11.76% vs. 1.59%). Conclusions: Pregnancy achieved by the IVF/ICSI method in which severe form of OHSS has been developed could have an increased risk of preterm birth. doi: https://doi.org/10.12669/pjms.35.4.145 How to cite this:Dobrosavljevic A, Rakic S, Mihajlovic S. Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.145 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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