Our results suggest that osteoblasts, as well as cells in periodontal ligament and gingival epithelium, respond to mechanical stress loaded by low-intensity pulsed ultrasound, and that ultrasound accelerates periodontal wound healing and bone repair.
The purpose of this study is to reconsider the attachment pattern and to evaluate the effects of Guided Tissue Regeneration (GTR) with Biodegradable collagen membrane (Tissue GuideTM) and enamel matrix protein (EMDOGAIN (R)) applied to experimental periodontal bone defects. The mesial roots of the lower third and fourth premolars from 10 beagle dogs were used. Mucoperiosteal flaps were reflected and bone defects were created measuring 5 mm in width and 5 mm in height. The experimental bone defects were treated by four different methods: (1) flap operation (control) ; (2) GTR with biodegradable collagen membrane (Tissue GuideTM) (T group) ; (3) applying enamel matrix protein (EMDOGAIN (R)) (E group) ; (4) GTR with Tissue GuideTM and EMDOGAIN (R) applied (TE group). After 6-12 weeks of healing, histologic sections were processed and histologically analyzed. In new cementum of T, E, and TE groups, hardly any cement cells were recognized, and no significant differences in attachment pattern among the three groups were noticeable. More significant new bone formation was found in the TE group than in the other groups, suggesting that GTR with Tissue GuideTM and EMDOGAIN (R) applyied may facilitate periodontal tissue regeneration. J.
The purpose of this study is to evaluate the effects of Guided Tissue Regeneration (GTR) with biodegradable collagen membrane (Tissue GuideTM) and natural apatite composition materials (Bone Ject (R)) for experimental periodontal bone defect. The mesial roots of the lower third and fourth premolars from 10 beagle dogs were used. Mucoperiosteal flaps were reflected and bone defects measuring 5mm in width and 5mm in height were created. The experimental bone defects were treated by four different methods : (1) flap operation (control) , (2) GTR with biodegradable collagen membrane (T group) , (3) grafting Bone Ject (R) (B group) , (4) CI GTR with Tissue GuideTM and grafting Bone Ject (R) (TB group). After 24 and 48 weeks of healing, histologic sections were processed and histologically observed, showing that the TB group produced more new bone and new cementum than the other groups. When granules of Bone Ject (R) remained, the structure was observed smaller. Our study suggested that Bone Ject (R) reconstract a periodontal tissue while it is absorbed partially.
The purpose of this study is to evaluate the availability of a bioabsorbable collagen barrier-membrane for guided bone regeneration (GBR). Subjects were 18 beagle dogs and materials were dome-shaped membranes. Prior to experiments, both first molars in the mandible were extracted. After 3 months of healing, mucoperiosteal flaps were reflected and experimental defects created in the alveolar bone. Theexperimental bone defect on one side was completely covered with the membrane (experimental group). On the contralateral side, the mucoperiosteal flap was repositioned without the membrane (controls). After 6 and 12 weeks postoperation, bone formation was determined by computer-assisted digital subtraction image analysis and histologically. The experimental group showd greater bone regeneration than controls under digital subtraction imaging. In controls, original bone crests were resorbed and bone formation at the bottom of the defect was slight. In the experimental group, slight resorption of original bone crests was observed and the defect was almost completely regenerated with new bone. This snggests that hioahsorhahle collagen membrane is feasibly biocompatible and provides suitable space for bone regeneration.
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