Low‐intensity pulsed ultrasound accelerates periodontal wound healing after flap surgery

Ikai, Hiroyuki; Tamura, Toshiyuki; Watanabe, Takuya; Itou, Masayuki; Sugaya, Akira; Iwabuchi, Sadahiro; Mikuni-Takagaki, Yuko; Deguchi, Shinji

doi:10.1111/j.1600-0765.2007.01016.x

Cited by 71 publications

(52 citation statements)

References 23 publications

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“…This helped in confirming that the PTVs were accurate. Our LIPUS irradiation method conformed to that used by Rego et al (11) and Ikai et al (15). However, we were able to include only 10 rats because it was difficult to reproduce definite ankylosis models, and thus, we used the minimum number of rats required to demonstrate effectiveness.…”

Section: Discussionmentioning

confidence: 99%

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A preliminary study of effects of low-intensity pulsed ultrasound (LIPUS) irradiation on dentoalveolar ankylosis

et al. 2017

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The purpose of this experiment was to investigate whether low-intensity pulsed ultrasound (LIPUS) irradiation can inhibit dentoalveolar ankylosis in transplanted rat teeth. LIPUS irradiation (the pulsed ultrasound signal had a frequency of 3.0 MHz, a spatial average intensity of 30 mW/cm 2 , and a pulse ratio of 1:4) was performed on the face over the re-planted teeth of rats for 4 weeks. After the rats were euthanized, we measured mobility (Periotest value [PTV]) of the transplanted and control teeth using a Periotest. Finally, we performed histological evaluation to detect ankylosis. PTVs tended to be significantly lower for re-planted teeth than for control teeth. Histological evaluation revealed that the roots of all re-planted teeth were coalescent with alveolar bone. Furthermore, no ankylosis was observed in three-fifths of the re-planted teeth following LIPUS irradiation. These results indicate the potential efficacy of LIPUS to inhibit dentoalveolar ankylosis.

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Section: Discussionmentioning

confidence: 99%

“…The pulsed ultrasound signal had a frequency of 3.0 MHz, a spatial average intensity of 30 mW/cm 2 , and a pulse ratio of 1:4 (2 ms on, 8 ms off) (15). Before undergoing LIPUS, general anesthesia was induced using 4% isoflurane and maintained under 1-2% isoflurane.…”

Section: Lipus(−) and Tr(+)lipus(+)mentioning

confidence: 99%

A preliminary study of effects of low-intensity pulsed ultrasound (LIPUS) irradiation on dentoalveolar ankylosis

et al. 2017

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“…Temporomandibular eklem bozuklukları tedavisi, ortodontik kök rezorpsiyonu, periodontal iyileşme etkisi araştırıl-mıştır. [12][13][14][15][16] Dentin pulpa rejenerasyonunu arttırdığına dair çok az bilgi mevcuttur fakat terapötik ultrason uygulaması ile odontoblast benzeri hücrelerde artış gösterilmiştir. 17 Vasküler endotelyal büyüme faktörü salınımında artış yapabileceği rapor edilmiştir.…”

Section: 11unclassified

Di̇ş Heki̇mli̇ği̇nde Düşük Yoğunluklu Kesi̇kli̇ Ultrason Kullanimi

Atıcı¹,

Ertaş²

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Ultrasound for diagnostic applications has a wide field of usage. As well as being used as a diagnostic tool, for therapeutic effects of ultrasound, low intensity and pulsed ultrasound is used. In recent years, lowintensity ultrasound usage has increased as supplementary treatment method especially in wound and bone healing. The effect of ultrasound on dentoalveolar structures has been attempted to enlighten by new studies. The purpose of this review is to describe the field of usage of the low intensity ultrasound.

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“…HSPAs may be induced in periodontal ligament cells in vitro due to reoxygenation following hypoxia of hypoxia-reoxygenation stress models (12) in gingival epithelial cells with local application of low-intensity pulsed ultrasound application (19), and via heat shock in osteoblasts, (20) indicating that HSPAs play an important role in the stress adaptation of most periodontal tissues. Furthermore, the higher serum level of specific human antibodies against microbial HSPAs, but importantly not against HSPAs of human origin, tends to positively correlate with healthier periodontal tissues (21), indicating that microbial heat shock proteins are immunodominant antigens triggering adaptive immunity of the organism to contribute to protection against oral microorganisms, and to maintain gingival health (21).…”

Section: Immune Surveillance and Periodontal Healthmentioning

confidence: 99%

The Role of Molecular Chaperones (Hspas/Hsp70S) in Oral Health and Oral Inflammatory Diseases: A Review

et al. 2009

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Heat shock proteins of the 70kDa family (HSPAs/HSP70s) are major molecular chaperones and cytokines of most cells and microbes, extracellular and interstitial fluids, blood, synovial fluids and secretory body fluids like saliva. The induction of human HSPAs plays an important role at cellular level under most stress conditions; whereas microbial HSPAs improve microbial tolerance to environmental changes, and improve virulence and resistance against antimicrobial peptides. Extracellular HSPAs reveal cytoprotective properties and are involved in numerous physiological and pathological events, including modulation of cytokine release and immunity. Accordingly, HSPAs play a role in the maintenance of pulpal health, and the repair of injured dental hard tissues. HSPAs also play a role in stress adaptation of periodontal tissues, and in the maintenance of periodontal and mucosal health including defense against microbes, prevention of mucosal allergic reactions, and facilitation of healing of ulcers and wounds. Despite their advantageous effects maintaining health of several oral tissues, HSPAs are likely to play a role in the disadvantageous amplification of pulpal inflammatory response to bacteria, and in the formation of several periapical inflammatory lesions. HSPAs may also induce gingivitis under certain conditions, and play a role in the progression of periodontal bone defects. HSPAs may also play a role in atopic-type allergic reactions, autoimmune disorders, and haptenation in certain cases. Based on the above data, it can be assumed that HSPAs play an important role in oral defense under healthy conditions; however, their role is somewhat “Janus-faced” under pathological conditions.

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Low‐intensity pulsed ultrasound accelerates periodontal wound healing after flap surgery

Abstract: Our results suggest that osteoblasts, as well as cells in periodontal ligament and gingival epithelium, respond to mechanical stress loaded by low-intensity pulsed ultrasound, and that ultrasound accelerates periodontal wound healing and bone repair.

Cited by 71 publications

References 23 publications

A preliminary study of effects of low-intensity pulsed ultrasound (LIPUS) irradiation on dentoalveolar ankylosis

A preliminary study of effects of low-intensity pulsed ultrasound (LIPUS) irradiation on dentoalveolar ankylosis

Di̇ş Heki̇mli̇ği̇nde Düşük Yoğunluklu Kesi̇kli̇ Ultrason Kullanimi

The Role of Molecular Chaperones (Hspas/Hsp70S) in Oral Health and Oral Inflammatory Diseases: A Review

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