The recurrence of low-fluence 1064-nm QS-Nd:YAG laser rates in melasma was high when the long-term results were considered. This result may be attributed to certain patient and treatment-related factors.
Fractional lasers have been used for the improvement of scar tissue in the recent years but there has not been extensive research on their impact. The purpose of this study was to evaluate the efficacy of nonablative fractional laser (NAFL) on acne, burn, and surgery/traumatic scar. The scars were also categorized as atrophic, hypertrophic, and keloid, and treatment efficacy was investigated accordingly. This is a retrospective, single-center study. Scar tissues were treated using a nonablative fractional 1550-nm Erbium glass laser in high-energy parameters at 4-week interval for 4-8 sessions. The scar regression score (SRS) was used to determine the decrease in scar appearance. Forty-six patients with acne (n:18), burn (n:13), or surgery/traumatic (n:15) scar were included. The number of sessions was higher for burn patients while SRS in burn patients was lower than in patients with acne or a surgical/traumatic scar. Evaluation according to scar types showed that atrophic scars had a significantly better response to NAFL treatment. This study indicates that NAFL treatment with the high-energy parameters has better outcomes in atrophic acne scars, while the success rate is considerably low in post-burn and keloid scars.
We observed that the quality of life in patients with AV was affected, and this effect was more significant in female patients, patients with severe acne and longer acne duration. We believe that the psychiatric/psychological effects should be followed up closely in this group of patients.
Background:Oral isotretinoin treatment might influence the levels of vitamin B12 and folic acid.Aims and Objectives:The aim of this study is to compare vitamin B12 and folic acid levels in patients with moderate and severe acne vulgaris with those of the healthy control group and to investigate the effect of isotretinoin treatment on these vitamins.Materials and Methods:Patients who completed 6 months of isotretinoin therapy for moderate and severe forms of acne vulgaris and a control group consisting of healthy individuals between February 2011 and March 2012 were included in the study. Before isotretinoin therapy and at 6.- months of the therapy, serum vitamin B12 and folic acid levels were measured. In the healthy control group, vitamin B12 and folic acid levels were assessed only once.Results:In total, 120 patients with moderate and severe acne vulgaris who completed 6 months isotretinoin therapy and 100 healthy individuals who constituted the control group were included in the study. Pre-treatment vitamin B12 values of the patient group were found to be statistically significantly higher (P = 0.002), but any statistically significant difference was not detected in folic acid measurements (P = 0.566). A statistically significant decrease was detected in post-treatment vitamin B12 and folic acid levels (P < 0.05).Conclusion:Vitamin B12/folic acid treatment should be given under medical surveillance before and during isotretinoin therapy. Supplementation of these vitamins should be recommended in cases of their deficiency, so as to decrease the risks of neuropsychiatric and occlusive vascular diseases.
Psoriazis, sistemik manifestasyonlarla birliktelik gösterebilen kronik hiperproliferatif bir deri hastalığıdır. Son yıllarda, metabolik sendrom veya metabolik sendrom komponentleri (obezite, insülin direnci, hipertansiyon ve aterojenik dislipidemi) ile artmış görülme sıklığı psoriazisin sistemik hastalık kategorisinde değerlendirilmesine neden olmuştur [1][2][3] . Ayrıca Background and Design: Psoriasis is a complex and chronic disease that may be associated with systemic diseases. In this study, our aim was to show the relationship of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values with disease severity. Additionally, the relationship between body mass index (BMI) values and inflammation markers was investigated. Materials and Methods: Sixty-two patients with chronic plaque psoriasis and 62 non-psoriasis patients were included in the study. Psoriasis severity was calculated using the psoriasis area severity index (PASI). The relationship of psoriasis severity with BMI, serum CRP and ESR values were investigated. In addition, psoriasis patient data were compared with control group data. Results: Of the 62 psoriasis patients included in the study, 31 (50%) were female and 31 (50%) were male. The ages of the patients ranged from 18 to 69 years and the mean age was 41.74±13.96 years. The mean PASI score was determined to be 15.86±8.95. CRP, ESR and BMI values were higher in psoriasis patients than in controls (p<0.05). In addition, CRP and BMI values were significantly increased as psoriasis severity increased (p<0.05). However, there was no relationship between ESR and psoriasis severity (p=0.82). Conclusion: CRP value can be used as an objective parameter for evaluating chronic inflammation in psoriasis patients.
ÖzetSon yıllarda metabolik sendrom ve onun komponentlerinden olan obezite ile psoriasis arasında güçlü bir ilişki olduğu düşünülmektedir. Obezite, genetik ve çevresel faktörlerin etkileşimi sonucu ortaya çıkan klinik bir bulgudur. Yağ dokusundan salgılanan adipokinlerin ve bunlar içerisinde leptinin psoriasis patogenezinde rol aldığı düşünülmektedir. Leptinin temel görevi iştahı kontrol ederek enerji dengesini sağlamaktır. Serum leptin düzeyleri yapılan çalışmalarda şiddetli psoriasisli hastalarda hafif psoriasislilere ve kontrol grubuna göre yüksek bulunmuştur. Leptin salınımının artışı sonucu ortaya çıkan biyolojik olayların psoriasis için karakteristik olan keratinosit proliferasyonunu tetiklediğine dair görüşler vardır. Psoriasis ile obezite arasındaki ilişkiyi inceleyen çok sayıda klinik çalışmada bu ilişki tespit edilmiştir. Ancak bazı çalışmalar obezlerde psoriasis görülme sıklığını yüksek bulurken, sınırlı sayıdaki diğerleri psoriasisli hastalarda obezite geliştiğini tespit etmişlerdir. Bunun yanında obez psoriasisli hastaların klasik topikal ve sistemik tedaviler yanında biyolojik tedavilere verdikleri yanıt konusunda da özellikler bulunmaktadır. Sonuç olarak psoriasis ile obezite arasındaki ilişkinin leptin düzeylerinin artışı ile ortaya çıktığına ve obez psoriasisli hastaların tedavisinde kilo kontrolünün önemine dair deliller giderek artmaktadır. (Türk derm 2012; 46: 3-6) Anah tar Ke li me ler: Psoriasis, obezite, adipositokinler, leptin Sum maryIn recent years, it has been thought that a strong association exists between metabolic syndrome, specifically obesity, and psoriasis. Obesity is a multifactorial disease affected by both genetic and environmental factors. Adipokines (e.g. leptin) secreted by the adipose tissue are believed to play a role in the pathogenesis of psoriasis. The main role of leptin is to adjust metabolism by controlling appetite. Serum leptin levels in patients with severe and moderate psoriasis were found to be higher than in normal control groups. In many similar studies, leptin secretion has been found to stimulate keratinocyte proliferation, which is one of the characteristics of psoriasis. Although many studies showed increased prevalence of obesity in psoriasis patients, few others reported development of obesity in psoriasis patients. Additionally, obesity was found to affect treatment responses not only in classical systemic/topical treatment approaches in psoriasis, but also in newer biological treatments. Overall, increasing epidemiological evidence suggests strong association between obesity and psoriasis, increase in serum leptin levels is thought to have a major role, and weight loss may have significant impact on response to treatment. (Turk derm 2012; 46: 3-6
Interface dermatitis is characterized by inflammatory infiltration dermoepidermal junction and defined as lichenoid tissue reaction. This histopathological appearance and pathophysiological process are mainly observed in lichen planus, lichenoid drug reaction, lichenoid autoimmune connective tissue disease, lichenoid purpura and lichenoid granulomatosis dermatitis. In this case, we report a 51-yearold female patient, diagnosed with lichenoid granulomatous dermatitis concurrence with myasthenia gravis and thymoma.
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