Psoriasis ve Obezite

Gürer, Mehmet Ali; Gökalp, Hilal

doi:10.4274/turkderm.98215

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…Epidemiyolojik çalışmalar psoriaziste obezite, diyabetes mellitus, hipertansiyon, hiperlipidemi ve koroner arter hastalığı prevalansının yüksek olduğunu göstermiştir [2][3][4]7,15 . Yüksek AN düzeyleri, bu hastalıklar için düşük riskle ilişkilendirilmiştir 9 .…”

Section: Discussionunclassified

Psoriaziste adiponektin düzeyi ve hastalık şiddeti ile ilişkisi

Tutkun¹,

Gül²,

Erdoğan³

et al. 2014

TURKDERM

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ÖzetAmaç: Psoriazis patogenezi tam olarak anlaşılamamış kronik inflamatuvar bir hastalıktır. Adipositlerden üretilen adiponektinin (AN) antidiyabetik, antiaterojenik ve antiinflamatuvar etkileri olduğu gösterilmiştir. Son yıllarda yapılan çalışmalarda metabolik sendrom düşük AN düzeyi ile ilişkilendirilmiştir. Literatürde az sayıda çalışmada psoriaziste AN düzeyi araştırılmıştır. Çalışmamızda psoriazisli olgularda AN düzeyini ve hastalık şiddeti ile ilişkisini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmamıza 46 psoriazis vulgarisli hasta ile yaş ve cinsiyet uyumlu 40 sağlıklı kontrol grubu dahil edildi. Hastaların dermatolojik muayeneleri yapıldı, psoriazis alan ve şiddet indeksi (PAŞİ) hesaplandı. Her 2 grupta demografik özellikler sorgulandı ve vücut kitle indeksi belirlendi. Serum AN ve CRP düzeyleri her iki grupta ölçüldü ve istatistiksel olarak karşılaştırıldı. Bulgular: Ortalama serum AN düzeyleri hasta grubunda kontrol grubuna göre daha düşük saptandı; ancak istatistiksel olarak anlamlı değildi. Serum AN düzeyi yaş, hastalık başlangıç yaşı ve hastalık süresi ile ilişkili bulunmadı. Psoriazis hastalarında CRP arttıkça, serum AN düzeyinin düştüğü tesbit edildi. PAŞİ arttıkça AN düzeyinde istatistiki olarak anlamlı azalma gözlendi. PAŞİ ile vücut kitle indeksi arasında istatistiki bir ilişki gözlenmedi. Sonuç: Psoriaziste AN düzeyi, metabolik sendrom ile birlikteliğinin bir göstergesi olabilir. Ayrıca psoriaziste hastalık şiddetinin değerlendirilmesinde de kullanılabilir; ancak adiponektinin psoriazis patogenezindeki rolü ve bu ilişkinin netlik kazanması için ayrıntılı incelemeleri içeren, farklı klinik modellerle yapılmış çalışmalara ihtiyaç vardır. Sum maryBackground and Design: Psoriasis is a chronic inflammatory disease in which the pathogenesis has not been completely understood yet. Adiponectin (AN) produced by adipocytes has antidiabetic, antiatherogenic and anti-inflammatory effects. Recent studies demonstrated that metabolic syndrome is related with low levels of AN. In the literature, there have been a few studies investigating AN levels in psoriasis. In this study, we purposed to investigate AN levels in patients with psoriasis. Materials and Methods: Forty-six patients with psoriasis and 40 age-and sex-matched healthy controls were included in our study. Dermatological examinations were performed and psoriasis area severity index (PASI) was calculated. In both groups, demographic features were questioned and body mass index were defined. Serum AN and C-reactive protein (CRP) levels were determined in both groups and were compared statistically. Results: The mean serum AN levels in patients were lower than in controls, but no statistically significant difference was detected between the groups. Serum levels of AN were not found to be associated with age, age at disease onset and disease duration. It was demonstrated that

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Section: Discussionunclassified

Psoriaziste adiponektin düzeyi ve hastalık şiddeti ile ilişkisi

Tutkun¹,

Gül²,

Erdoğan³

et al. 2014

TURKDERM

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“…Fatty acid binding protein 4 (FABP4) is a newly described adipocytokine that is released from adipocytes and macrophages [13] and is associated with the development of metabolic syndrome (MetS), insulin resistance, and increased inflammation. The level of FABP4 has been suggested to be a novel marker that can strongly predict the risk of MetS development and CVD [14]. Regression in atherosclerotic lesions has been reported after treatment with a FABP4 inhibitor [15].…”

Section: Introductionmentioning

confidence: 99%

“…FABP4 expression is strongly induced during the differentiation of adipocytes as well as the differentiation of macrophages from monocytes. The induction of these cells is regulated by proinflammatory stimuli [14], which in turn are known to be regulated by triiodothyronine (T3) [16].…”

Section: Introductionmentioning

confidence: 99%

FABP4 levels in hypothyroidism and its relationship with subclinical atherosclerosis

et al. 2019

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Background/aim: The aim of this study is to evaluate the relationship between serum fatty acid binding protein 4 (FABP4) levels and carotid intima media thickness (CIMT) in patients with hypothyroidism. Materials and methods: Forty subclinical hypothyroidism patients, 40 overt hypothyroidism patients, and 40 healthy controls were enrolled in the study. Blood pressure, body mass index, CIMT, fasting blood sugar, creatine, alanine aminotransferase, lipid parameters, insulin, free thyroxine, triiodothyronine, thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), high-sensitivity C-reactive protein (Hs-CRP), and FABP4 levels of all participants were measured. Results: Serum FABP4 levels were significantly higher in patients with subclinical and overt hypothyroidism than healthy controls (HCs) (P = 0.044 and P = 0.014, respectively). There was no significant difference in terms of FABP4 levels between patients with subclinical and overt hypothyroidism (P = 0.641). Serum TSH levels and serum FABP4 levels were positively correlated (r = 0.201, P = 0.039). CIMT was found to be higher in patients with subclinical and overt hypothyroidism than in HCs (P = 0.042 and P < 0.001, respectively). No correlation was found between CIMT and FABP4 levels (r = 0.038, P = 0.702). There was a positive correlation between CIMT and TSH, anti-TPO, anti-TG, triglycerides (TG), and total cholesterol levels. It was found that high TG levels were an independent factor that increased CIMT (r = 0.382, r 2 = 0.146). Conclusion: In patients with subclinical and overt hypothyroidism, the level of FABP4 increases and this increase is correlated with the increase in TSH level. It is thought that FABP4 does not play a role in atherosclerosis development in patients with hypothyroidism without metabolic disorder.

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“…Temel patolojileri yaygın sistemik inflamasyon olan bu hastalıkların, birlikte sık görülmeleri ve komplikasyonların ortaya çıkışı, psoriasisin bir deri hastalığı olmaktan öte sistemik bir hastalık olabileceğini düşündürmektedir 4 . Son yıllarda yapılan çalışmalarda obezitenin inflamatuvar bir durum ve yağ dokusunun immün ve endokrin bir organ olduğu düşünülmüştür 5 . Obezite sistemik inflamasyonu arttırarak, psoriasis gelişiminde bağımsız bir risk faktörü olarak rol oynar ve yine hastalık ciddiyeti ile ilişkilidir 6 .…”

Section: Introductionunclassified

The effect of psoriasis treatment on body composition, components of metabolic syndrome and psoriatic arthritis

Tamer¹,

Gürer²

2015

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Background and Design:Psoriasis is a chronic inflammatory immune-mediated skin disorder with unknown etiology. Chronic inflammation in psoriasis has a role in the development of metabolic and vascular disorders related with associating comorbidities. Recent studies have suggested a strong association between psoriasis and obesity, which is one of the components of metabolic syndrome, and emphasized the complex relationship of psoriasis treatment with psoriasis and body mass index (BMI). In this study, our aim was to investigate the effect of psoriasis treatment with methotrexate, cyclosporine and biological agents on body composition, comorbidities and associated laboratory findings. Materials and Methods: Seventy-nine patients treated with methotrexate, cyclosporin and biological agents were included in our study. Demographic characteristics, body composition analysis, psoriasis-related comorbidities and laboratory examinations were evaluated before and after 12 weeks of systemic treatment. Results: Comorbidities and metabolic syndrome tended to be more frequent in the anti-tumor necrosis factor alpha (anti-TNF-α)-treated group. Increase in body fat and weight detected in patients receiving biologic drug therapy. Conclusion:The results of our study showed that patients with severe psoriasis with longer disease duration were more likely to have metabolic syndrome because of severe and long-term inflammation in the pathogenesis of comorbidities. (Turkderm 2015; 49: 41-4)

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Psoriasis ve Obezite

Cited by 6 publications

References 31 publications

Psoriaziste adiponektin düzeyi ve hastalık şiddeti ile ilişkisi

Psoriaziste adiponektin düzeyi ve hastalık şiddeti ile ilişkisi

FABP4 levels in hypothyroidism and its relationship with subclinical atherosclerosis

The effect of psoriasis treatment on body composition, components of metabolic syndrome and psoriatic arthritis

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