Effect of psoriasis severity on inflammation parameters: Controlled study

Gökalp, Hilal

doi:10.4274/turkderm.05025

Cited by 7 publications

(9 citation statements)

References 22 publications

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“…The two groups were homogeneous for clinical, anthropometric, and laboratory parameters with the exception of total cholesterol values that were higher in Pso vs. Ctrl, in agreement with lipid abnormalities associated with this disease [15,42,43]. Also, erythrocyte sedimentation rate (ESR) was higher in Pso compared to Ctrl, and ESR is a delayed inflammatory biomarker known to increase in Pso [44]. Blood pressure, wave reflection analyses, and PWV were similar in the Pso and Ctrl groups (Table 3).…”

Section: Resultsmentioning

confidence: 80%

The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk

Magenta

D'agostino

Sileno

et al. 2019

Oxidative Medicine and Cellular Longevity

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Psoriasis is a chronic inflammatory skin disease associated with reactive oxygen species (ROS) increase and a higher risk of cardiovascular (CV) events. We previously showed that the miR-200 family (miR-200s) is induced by ROS, miR-200c being the most upregulated member responsible for apoptosis, senescence, ROS increase, and nitric oxide decrease, finally causing endothelial dysfunction. Moreover, circulating miR-200c increases in familial hypercholesterolemic children and in plaques and plasma of atherosclerotic patients, two pathologies associated with increased ROS. Given miR-200s’ role in endothelial dysfunction, ROS, and inflammation, we hypothesized that miR-200s were modulated in lesional skin (LS) and plasma of psoriatic patients (Pso) and that their levels correlated with some CV risk determinants at a subclinical level. All Pso had severe psoriasis, i.e., Psoriasis Area and Severity Index PASI>10, and one of the following: at least two systemic psoriasis treatments, age at onset<40 years, and disease duration>10 years. RNA was extracted from plasma (Pso, N=29; Ctrl, N=29) and from nonlesional skin (NLS) and LS of 6 Pso and 6 healthy subject skin (HS) biopsies. miR-200 levels were assayed by quantitative RT-PCR. We found that all miR-200s were increased in LS vs. NLS and miR-200c was the most expressed and upregulated in LS vs. HS. In addition, circulating miR-200c and miR-200a were upregulated in Pso vs. Ctrl. Further, miR-200c positively correlated with PASI, disease duration, left ventricular (LV) mass, LV relative wall thickness (RWT), and E/e′, a marker of diastolic dysfunction. Multiple regression analysis indicates a direct association between miR-200c and both RWT and LV mass. Circulating miR-200a correlated positively only with LV mass and arterial pressure augmentation index, a measure of stiffness, although the correlations were nearly significant (P=0.06). In conclusion, miR-200c is upregulated in LS and plasma of Pso, suggesting its role in ROS increase and inflammation associated with CV risk in psoriasis.

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Section: Resultsmentioning

confidence: 80%

The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk

Magenta

D'agostino

Sileno

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Skin inflammation in psoriasis patients is usually accompanied by systemic inflammation and progressively increased with increasing psoriasis severity. 32 CRP might be considered a good indicator of psoriasis severity and showed a significant decrease with treatment. 33 There are several limitations of our study; the study sample had a relatively small size.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Effect of Metabolic Syndrome on the Autophagy Marker LC3 in Psoriasis Vulgaris Patients: A Cross-Sectional Study

Nada

Muhammad

Ahmed

et al. 2020

CCID

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Purpose Psoriasis vulgaris, one of the most prevalent chronic inflammatory skin diseases, is associated with metabolic syndrome (MetS). Autophagy, an intracellular degradation system is essential for cell survival and differentiation, and its dysfunction may contribute to metabolic diseases. A cross-sectional study was conducted on 38 psoriasis vulgaris patients and 16 healthy control subjects to 1) Assess immunohistochemical (IHC) expression of microtubule-associated protein light chain 3 (LC3); 2) Evaluate the relationship between Psoriasis Area Severity Index (PASI) score, and LC3 expression. Patients and Methods PASI score was evaluated for all psoriasis patients. Lipid profile, blood sugar, and CRP were done for all patients and controls. A punch biopsy was taken from lesional and perilesional skin of psoriasis patients and normal skin of the controls. Tissue sections were prepared. IHC LC3 staining was done and evaluated. Results LC3 was nearly absent, in the epidermis of the lesional skin of psoriasis while it was strong among control (p=0.001). LC3 expression in the lesional skin of psoriasis vulgaris was lower than its expression in perilesional (p=0.001). However, LC3 expression was not significantly changed with PASI or the presence/absence of MetS. Conclusion A potential link between psoriasis vulgaris and autophagy as assessed by LC3 could be present. LC3 was down-regulated in psoriasis lesions than in normal skin. However, its expression did not change with PASI or MetS. An autophagy enhancer might be used as a possible therapeutic target in psoriasis vulgaris patients.

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“…Consistent to our findings for the PLR, we found significant differences in ESR between PsA and PsV groups, and between PsA and control groups. In other studies, the ESR was higher in PsA patients compared to PsV patients and in PsV patients compared to controls [15,27].…”

Section: Discussionmentioning

confidence: 59%

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory markers in psoriasis: a case-control study

Nguyen

Pham

2022

Dermatol Reports

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Our case–control study of 60 patients with PsV, 20 patients with PsA, and 34 healthy control participants in Ho Chi Minh City Hospital of Dermato-Venereology from October 2019 to September 2020 aimed to evaluate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and associated factors in patients with psoriasis vulgaris (PsV) and PsA. Results showed that in the PsV group, significant correlations of NLR with PASI and the hs-CRP level was noted (r=0.374 and r=0.352, respectively; p=0.003 and p=0.006, respectively). NLR was also related to PsA (p=0.007, OR=1.57). The area under the curve (AUC) for NLR in predicting PsA was 0.7554 (cut-off, 2.239; sensitivity, 85%; specificity, 61.67%). PLR was also related to PsA (p=0.008, OR=1.01). The AUC for PLR was 0.6513 (cut-off, 159.6; sensitivity, 55%; specificity, 88.33%). Thus, complete blood count parameters can reflect the inflammatory status of patients with PsV and PsA. NLR and PLR may be potential diagnostic markers for PsA in patients with psoriasis. Future studies should aim to assess the value and usage of these parameters.

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Effect of psoriasis severity on inflammation parameters: Controlled study

Cited by 7 publications

References 22 publications

The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk

The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk

Assessment of the Effect of Metabolic Syndrome on the Autophagy Marker LC3 in Psoriasis Vulgaris Patients: A Cross-Sectional Study

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory markers in psoriasis: a case-control study

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