Psychosocial Aspects of Hair Loss

Gökalp, Hilal

doi:10.5772/66156

Cited by 10 publications

(14 citation statements)

References 36 publications

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“…To the best of our knowledge, dermatological traits have not been previously recognized as associated with 16p11.2 duplications or deletions. Telogen effluvium (stress-induced hair loss) can be potentially explained as a symptom of brain-related disorders, or a side effect of drugs used to treat bipolar disorder or schizophrenia [88,89]. Similarly, the novel diagnosis of retention of urine may refer to a side effect of drugs used to treat epilepsy, schizophrenia, and bipolar disorder [90].…”

Section: Ino80ementioning

confidence: 99%

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Vysotskiy

Zhong

Zhou

et al. 2020

Preprint

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Deletions and duplications of the 16p11.2 and 22q11.2 copy number variant (CNV) regions are associated with brain-related disorders including autism spectrum disorder, schizophrenia, bipolar disorder, obesity, and intellectual disability. The contribution of individual genes in each CNV to each phenotype is unknown. We propose a novel in silico approach to systematically interrogate each gene's effect on brain-related disorders. As CNVs affect RNA copy number, we attempted to fine-map each CNV region by asking whether natural gene expression variation in any individual gene would increase risk for the same disorder(s). We first used large genotyped cohorts for five CNV-associated traits: autism spectrum disorder, schizophrenia, bipolar disorder, BMI, and IQ. Imputing the transcriptome from the genome, we performed association testing for CNV genes with the genotype datasets. We found individual genes within 16p11.2 associated with schizophrenia (TMEM219, INO80E, YPEL3), BMI (TMEM219, SPN, TAOK2, INO80E), and IQ (SPN), with independent replication. Using a conditional analysis, we showed that INO80E explains the schizophrenia association. Second, we used a biobank containing electronic health data and genotypes for 23,000 individuals to perform phenome-wide association studies with predicted expressions of 16p11.2 and 22q11.2 genes and over 1,500 health traits, finding eight significant gene-trait pairs. Third, we compared the medical phenome of CNV carriers to controls within an independent group of 3 million individuals. We identified CNV traits may have indicated genetic testing, other traits previously observed in CNV carriers, and novel traits. Our results provide new insight into the contribution of individual CNV genes to CNV-associated traits. Limitations

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Section: Ino80ementioning

confidence: 99%

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Vysotskiy

Zhong

Zhou

et al. 2020

Preprint

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“…It starts all of a sudden and causes hair loss with sharp and circular borders. 4 Although the exact etiopathology is largely unknown; the factors known to play some role in its development are: genetic, immunological, environmental, infectious, or psychological. Alopecia areata and its significant effect on the quality of life in relation to psychological factors has been studied in more details.…”

Section: The Impact Of Hair Lossmentioning

confidence: 99%

“…Alopecia areata and its significant effect on the quality of life in relation to psychological factors has been studied in more details. 4 Alopecia areata patients as compared with other individuals are also reported to be more commonly affected with social and family problems and they have reduced capacity to cope with events.…”

Section: The Impact Of Hair Lossmentioning

confidence: 99%

Psychology of Hair Loss Patients and Importance of Counseling

Dhami

2021

Indian J Plast Surg

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Androgenetic alopecia (AGA) is highly prevalent in society, affecting both men and women. More than the sociological meaning of hair loss, it has become a very important part of self-identity or “body image.” A psychological concept of body image refers to one's thoughts, feelings, perceptions, and behavioral changes related to one's physical looks. In spite of alopecia's common occurrence, it often leads to psychological disturbance and distress. Hair thinning and perceived hair loss also has a very important negative impact on the psyche of the individual. The common emotional aspects associated are self-consciousness, embarrassment, frustration, and jealousy. Knowledge of these effects among the clinicians managing hair loss patients is beneficial. The clinician must make an active effort to identify the borderline group of patients with body dysmorphic syndrome so as to manage them with psychotherapeutic medication for their hair loss prior to hair transplantation. This article aims to provide important information and an understanding of how the psychology gets affected due to hair loss, particularly AGA and its management to the practicing hair transplant surgeons.

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“…Impaired emotional awareness, difficult social cohesion, and limited interpersonal relationships are among its main features 55 . It has been suggested that alexithymia should be considered when assessing the psychopathological status of patients with AA 56 …”

Section: Psychopathology Of Aamentioning

confidence: 99%

Alopecia areata: A psychodermatological perspective

Torales

Castaldelli-Maia

Ventriglio

et al. 2021

J of Cosmetic Dermatology

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Background Alopecia Areata (AA) is an autoimmune dermatological disease that could be influenced by psychological factors as part of the pathophysiology of the illness. Aims This review article aims to report on psychodermatological and psychopathological aspects involved in the etiopathogenesis and comorbidities of AA, as well as on the psychiatric and psychological management of affected patients. Methods We conducted a literature search on PubMed and Google Scholar from January 1980 to May 2021 employing the search terms of alopecia areata, psychological factors, psychological impact, psychodermatology, and psychopathology. All lists of references from the identified articles were screened for further relevant studies. The search was limited to English and Spanish language articles and was supplemented with themed books and book chapters. No specific quality criteria were used for the studies selection. Results Several authors have found a high comorbidity rate between AA and mental disorders, concluding that stress and psychological factors are involved in both the development and exacerbation of the illness. More evidences are needed in order to describe the associations between the immune response, stress, and the physiological factors observed in AA patients. Conclusion AA is a complex illness characterized by multifactorial etiology. An interaction between genetic, autoimmune, hormonal, neural, and psychological factors is supposed. Psychopathological aspects of illness need to be better described and considered in the clinical setting.

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Psychosocial Aspects of Hair Loss

Cited by 10 publications

References 36 publications

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Psychology of Hair Loss Patients and Importance of Counseling

Alopecia areata: A psychodermatological perspective

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