The complex of structural changes in the gastroduodenal mucosa in patients with bronchial asthma is considered as a polyetiological primary degenerative process with progressive atrophy of the epithelium and formation of erosions. Ultrastructural signs included degenerative changes in the endothelium of microvessels and surface and glandular epithelium, which were accompanied by compensatory hyperfunction of intact mucus-producing cells, hyperplasia, and increased functional activity of mast and immunocompetent cells. The development of destructive and erosive lesions was associated with hyperplasia of parietal and endocrine cells in the mucosa. We evaluated the specific structural reactions clinically typical of bronchial asthma of different severity. The data are interpreted in terms of a relationship between pathological changes in the mucosa of different localization.
The aim of the study was to ventilation function of lungs and echocardiography activities right and left ventricular, blood flow disorders in pulmonary artery in confront with clinical pictures and activities portal haemodynamics in patients with a liver cirrhosis. Established, that change structural-functional activities right and left parts of heart in a liver cirrhosis depend on to a great extent, to a weight of disease and to be accompanied raorganisation of a central haemodynamics and forming pulmonary arterial hypertension. Pulmonary arterial hypertension in close association with portal circulation of the blood and represented not rare complication of a liver cirrhosis.
The article presents data concerning prevalence of sarmidosis in Tomsk and the Tomsk region for 16 years and impacting of ecological and geochemical factors (elemental composite of incrustation of snow, soils) on disease. The sarmidosis morbidity of individuals without undergoing impact of occupational hazards is reliably higher in areas with increased anthropogenic loading (the Oktiabrskii district of Tomsk, the Tomsk rural district, the North- Eastern sector, city of Seversk, Parabelskii and Kolpashevskii districts, Strejevoii). The positive associations were established between sarmidosis morbidity and content of sodium in incrustation of snow, cerium in soil. The sarmidosis with severe recurrent course correlated positively with lutetium and chrome of soils and negatively with barium in incrustation of snow.
2ОГАУЗ «Томская областная клиническая больница», г. Томск, Р осси я Саркоидоз представляет собой системное заболевание, характеризующееся развитием хронического иммунного воспаления и образованием гранулем. С целью изучения патоморфологических особенностей гранулемы важно знать клинико-морфологические и иммунологические варианты течения процесса. В последнее время отмечена отрицательная тенденция в динамике патоморфоза саркоидоза. В этой связи важным является изучение во просов прогнозирования развития данного заболевания, в том числе и особенностей течения гранулематозного воспалительного процесса при различных клинических вариантах с точки зрения не только диагностики, но и определения дальнейшей тактики ведения пациентов с этой патологией.
Aim. To study clinical and morphological phenotypes in different variants of the course of intrathoracic sarcoidosis and isolate new phenotypes.Materials and methods. The study included 121 patients with intrathoracic sarcoidosis aged 21–66 years (50.4% were men, 49.6% were women, the average age at the time of the disease onset was 38 years) over the period 2007– 2019. During the examination, patients’ complaints were studied thoroughly, and the diagnosis was histologically verified in all cases. During an extended histological examination, the quantitative and qualitative composition of biopsy specimens was investigated. The number of granulomas in the field of vision and the content of giant cells, macrophages, lymphocytes, neutrophils, and eosinophils in them were studied. Qualitative parameters were assessed for the presence of hyalinosis, Schaumann bodies, necrosis, stamping, calcification, fibrosis, and vasculitis. All patients were retrospectively divided into two clinical groups depending on the outcomes of the disease: group 1 included patients with a favorable course of sarcoidosis, proceeding without relapses and signs of progression; group 2 encompassed patients with an unfavorable course of the disease with relapses and progression, requiring long-term administration of systemic glucocorticoids.Results. The analysis showed that among all general clinical manifestations, only the presence of dyspnea, skin manifestations, and weight loss occurred significantly more often in the patients with an unfavorable course of intrathoracic sarcoidosis (р = 0.04; 0.02; and 0.01, respectively). Among morphological parameters, a large number of macrophages was significantly more frequent in the biopsy specimens in this group of patients (р < 0.01).
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