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130 patients with multiple myeloma were revieved for a retrospective study of their classification according to Durie & Salmon. No significant difference was found in survival between patients in stages I, I1 and 111 (median survival 24.8, 32.1, and 17.3 months, respectively). Of the classical criteria affecting survival, only the H b level showed any significant influence (P < 0.04). In accordance with this finding, the survival time was much shorter (P < 0.001) in patients with renal failure than in patients without (median survival 7.4 and 24.8 months, respectively); in addition, thrombopenia, fever, old age, and above all, the 7 G of bone-marrow plasmocytes present, were shown to be decisive factors.

This retrospective study deals with the clinical, radiological and biological data of 16 patients suffering from sarcoid arthritis with (n = 11) and without (n = 5) erythema nodosum (EN). The average age and sex distribution were the same and we failed to demonstrate any significant difference between the two groups. However, it is worth noting that the average number of the joints affected was less in a patient with (3.0) than in a patient without EN (4.8) and that persistence of polyalgias was associated with EN. Nevertheless, one may assume that the current series corroborates the common immunological pathophysiology of these two pictures of sarcoid arthritis.

Pi typing was carried out by high resolution isoelectric focusing in 397 Bigoudens and in 100 non-Bigouden Bretons. Gene frequencies were computed by the gene counting method. No difference between the two groups could be demonstrated, neither was there a deviation from the expected Hardy-Weinberg distribution nor a heterogeneity between the Bigouden villages. The results were significantly different (p < 0.02) from those reported in Normans.

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Despite the strict criteria required to distinguish Multiple Myeloma (M.M.) or Waldström's Macroglobulinemia (W.M.) from Benign Monoclonal Gammapathy (B.M.G.), nosological frontiers are still unclear and accordingly justify a comparative serological study of M.M., W.M., and B.M.G. patients.

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