Comparison of the Manifestations of Acute Sarcoid Arthritis with and Without Erythema Nodosum:<i>Immunopathogenic Significance</i>

Pennec, Y; Youinou, Pierre; Goff, P. Le; Boles, Jean-Michel; Menn, G. Le

doi:10.3109/03009748209098106

Cited by 11 publications

(4 citation statements)

References 20 publications

(3 reference statements)

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“…The average duration of symptoms is approximately 2 to 3 months, and most patients go into remission by 6 months after receiving nonsteroidal antiinflammatory drugs or steroids. 39,41,[46][47][48][49][50][51]…”

Section: Acute Sarcoid Arthritismentioning

confidence: 99%

Rheumatologic Manifestations of Sarcoidosis

Sweiss

Patterson

Sawaqed

et al. 2010

Semin Respir Crit Care Med

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Sarcoidosis is a systemic, clinically heterogeneous disease characterized by the development of granulomas. Any organ system can be involved, and patients may present with any number of rheumatologic symptoms. There are no U.S. Food and Drug Administration–approved therapies for the treatment of sarcoidosis. Diagnosing sarcoidosis becomes challenging, particularly when its complications cause patients’ symptoms to mimic other conditions, including polymyositis, Sjögren syndrome, or vasculitis. This review presents an overview of the etiology of and biomarkers associated with sarcoidosis. We then provide a detailed description of the rheumatologic manifestations of sarcoidosis and present a treatment algorithm based on current clinical evidence for patients with sarcoid arthritis. The discussion will focus on characteristic findings in patients with sarcoid arthritis, osseous involvement in sarcoidosis, and sarcoid myopathy. Arthritic conditions that sometimes coexist with sarcoidosis are described as well. We present two cases of sarcoidosis with rheumatologic manifestations. Our intent is to encourage a multidisciplinary, translational approach to meet the challenges and difficulties in understanding and treating sarcoidosis.

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Section: Acute Sarcoid Arthritismentioning

confidence: 99%

Rheumatologic Manifestations of Sarcoidosis

Sweiss

Patterson

Sawaqed

et al. 2010

Semin Respir Crit Care Med

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“…The clinical characteristics of sarcoid arthritis have been described in several studies. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Based on the clinical course of the disease, two major types of arthritis have been classically distinguished: the acute transient type and the persistent or chronic type. The acute form is the most common rheumatic manifestation of sarcoidosis, often being the presenting manifestation of the disease and generally having a favourable outcome.…”

mentioning

confidence: 99%

Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors

Visser

Vos²,

Zanelli³

et al. 2002

Annals of the Rheumatic Diseases

125

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Objectives: (a) To describe the clinical characteristics of acute sarcoid arthritis and the diagnostic value of its presenting clinical features; (b) to evaluate whether disease onset is seasonal; and (c) to evaluate whether smoking behaviour or the presence of HLA class II alleles is a risk factor for the disease. Methods: 579 consecutive patients with recent onset arthritis who had been newly referred to a rheumatology outpatient clinic were included in a prospective cohort study. The presenting clinical features, the smoking behaviour, and the results of HLA-DQ and HLA-DR DNA typing of 55 patients with sarcoid arthritis, 524 patients with other arthritides of recent onset, and samples of the normal population were compared. Results: In all cases the disease showed a self limiting arthritis and overall good prognosis. The diagnostic ability of a combination of four clinical features-symmetrical ankle arthritis, symptoms of less than two months, age below 40 years, and erythema nodosum-was exceptionally high. When test positivity is defined as the presence of at least three of four criteria the set rendered a sensitivity of 93%, a specificity of 99%, a positive predictive value of 75%, and a negative predictive value of 99.7%. The disease clustered in the months March-July. The disease was negatively associated with smoking (odds ratio (OR) 0.09; 95% confidence interval (95% CI) 0.02 to 0.37) and positively associated with the presence of the DQ2 (DQB1*0201)-DR3 (DRB1*0301) haplotype (OR 12.33; 95% CI 5.97 to 25.48). Conclusion: The disease entity acute sarcoid arthritis has highly diagnostic clinical features. The seasonal clustering, the protective effect of smoking, and the association with specific HLA class II antigens support the hypothesis that it results from exposure of susceptible hosts to environmental agents through the lungs.

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“…Le Goff considered the case by Matsuda et al to be the only case of sarcoidosis that corresponds to the description by McCarty et al (5). Third, isolated manifestation of RS3PE at the lower extremities is not considered as an exclusion criterion for RS3PE (6,7), although we agree that RS3PE of the hands was present in all patients in the article by McCarty et al (5). Fourth, young age and male sex are not exclusion criteria for RS3PE, although we concede that RS3PE is more common in elderly males.…”

Section: To the Editorsmentioning

confidence: 89%

“…Second, red appearance of pitting edema, which was argued against the diagnosis of RS3PE by Le Goff, was also present in the case by Matsuda et al (4). Le Goff considered the case by Matsuda et al to be the only case of sarcoidosis that corresponds to the description by McCarty et al (5). Third, isolated manifestation of RS3PE at the lower extremities is not considered as an exclusion criterion for RS3PE (6,7), although we agree that RS3PE of the hands was present in all patients in the article by McCarty et al (5).…”

Section: To the Editorsmentioning

confidence: 92%

Diagnosis of remitting seronegative symmetrical synovitis with pitting edema in a patient with sarcoidosis: Comment on the article by Dejaco et al

Goff¹

2008

Arthritis & Rheumatism

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Comparison of the Manifestations of Acute Sarcoid Arthritis with and Without Erythema Nodosum:Immunopathogenic Significance

Cited by 11 publications

References 20 publications

Rheumatologic Manifestations of Sarcoidosis

Rheumatologic Manifestations of Sarcoidosis

Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors

Diagnosis of remitting seronegative symmetrical synovitis with pitting edema in a patient with sarcoidosis: Comment on the article by Dejaco et al

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