HLA Antigens and Monoclonal Gammapathy

Saleun, J.P.; Youinou, Pierre; Goff, P. Le; Menn, G. Le; Morin, Jean Paul

doi:10.1111/j.1399-0039.1979.tb00789.x

Cited by 18 publications

(2 citation statements)

References 7 publications

(3 reference statements)

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“…A study on German, Dutch, American, and English subjects showed a weak association between HLA-B5 and MM [ 8 , 9 , 10 , 17 ]. No significant HLA-A and -B allele associations were demonstrated in French and Swiss MM patients, although the MM patients from another area of France showed a negative association between HLA-Aw32 and MM [ 6 , 7 , 12 ]. Ludwig and Mayr, in 1982, reported that comparisons between all available studies showed a significantly increased frequency of HLA-B5 [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since the HLA genes are associated with a variety of immunologic diseases, they may be involved as a crucial factor in MM [ 6 ]. In 1970 for the first time, after recognition of HLA class 1 and prior to identification of HLA class 2, the susceptibility effects of HLA genes on MM were studied [ 7 , 8 , 9 , 10 , 11 , 12 ]. Not many studies have taken sufficient account of the effect of HLA genes on the susceptibility to MM in different populations.…”

Section: Introductionmentioning

confidence: 99%

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The Association of HLA Class 1 and Class 2 Antigens with Multiple Myeloma in Iranian Patients

Sayad¹,

Akbari²,

Mehdizadeh³

et al. 2014

Tjh

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Objective: Multiple myeloma (MM) is a B-cell malignancy characterized by the clonal proliferation of malignant plasma cells. According to results of some studies, it has been suggested that the HLA class 1 and 2 genes have susceptibility effects on MM. Studies of different populations have reported different HLA class 1 and 2 alleles that affect MM. In this study, we assessed the association of HLA class 1 and class 2 antigens with MM in Iranian patients. Materials and Methods: We performed a case-control genotyping study with 105 Iranian MM patients that were selected from the bone marrow transplantation department of Taleghani Hospital and 150 controls using single specific primer-polymerase chain reaction with the HLA-Ready Gene ABDR Kit.Results: Our results demonstrated that 21% of patients versus 12% of controls and 11% of patients versus 3% of controls carried HLA-A*03 and HLA-B*18, respectively. The MM patients had a significant increase in the frequency of HLA-A*03 and HLA-B*18 alleles in comparison to control subjects (p=0.039, OR=2.057 and p=0.013, OR=3.567, respectively). Conclusion: Our findings suggested that the HLA-A*03 and HLA-B*18 alleles have significant susceptibility effects on MM in the Iranian population. However, compared to other populations, the above-mentioned alleles had different statuses. Since there are not many studies evaluating and calculating this association among ethnic groups, further studies among other populations are needed to explain the exact association of the HLA genes with MM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association of HLA Class 1 and Class 2 Antigens with Multiple Myeloma in Iranian Patients

Sayad¹,

Akbari²,

Mehdizadeh³

et al. 2014

Tjh

View full text Add to dashboard Cite

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Genetic studies in multiple myeloma 1. Association with HLA-Cw5

Leech

Bryan

Elston

et al. 1983

Cancer

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Multiple myeloma in two brothers. An immunochemical and immunogenetic familial study

Grosbois

Guéguen

Fauchet

et al. 1986

Cancer

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When multiple myeloma was diagnosed within 6 months in two brothers a family study was carried out in 34 relatives to assess the genetic factors involved. The monoclonal immunoglobulin isotype identified was identical for the two brothers (IgG kappa) as well as their genotype (a = A2B12BfSDR4 GIo2/d:A9B27BfSDR2GIol). Blood protein electrophoresis and the major histocompatibility complex markers (HLA A, B, DR, Bf, glyoxalase phenotypes) were also determined in the other family members. The immunochemical study revealed no other case of monoclonal gammapathy, but 12 cases of low gamma-globulin and three cases of polyclonal hypergammapathy were found. The immunogenetic study showed that no other family member had the a/d genotype of the two brothers, whereas nine family members were semi-identical for haplotype a and five for haplotype d. It is unlikely that a double immunochemical and immunogenetic identity in two siblings with multiple myeloma would be due only to random encounter, rather this finding suggests that, besides environmental factors, genetic factors may be involved in the pathogenesis. Systematic immunochemical and immunogenetic studies in familial multiple myeloma are proposed as a method to further elucidate an eventual genetic background in multiple myeloma.

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HLA Antigens and Monoclonal Gammapathy

Cited by 18 publications

References 7 publications

The Association of HLA Class 1 and Class 2 Antigens with Multiple Myeloma in Iranian Patients

The Association of HLA Class 1 and Class 2 Antigens with Multiple Myeloma in Iranian Patients

Genetic studies in multiple myeloma 1. Association with HLA-Cw5

Multiple myeloma in two brothers. An immunochemical and immunogenetic familial study

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