Multiple myeloma in two brothers. An immunochemical and immunogenetic familial study

Grosbois, B.; Guéguen, M.; Fauchet, R.; Lebouc, Hervé; Guenot, A.; Lancelin, Francois; Lauvin, R.; Leblay, R; Genetet, B

doi:10.1002/1097-0142(19861201)58:11<2417::aid-cncr2820581111>3.0.co;2-s

Cited by 14 publications

(10 citation statements)

References 32 publications

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“…It has been suggested that in Waldenstrom's macroglobulinaemia there is an autosomal dominant mode of transmission linked to the HLA A2 B8 DR3 haplotype (Reiner et al, 1989), although other familial reports of this disease have failed to show a common haplotype. Grosbois et al (1986) described two brothers with multiple myeloma who had identical HLA Comparison of age at diagnosis of malignant plasma cell dyscrasia between the observed cases and those in the general population. A significant difference is observed between the age at diagnosis in the child generation (P < 0·005), but not between that of the parent generation and cases in the general population.…”

Section: Discussionmentioning

confidence: 99%

Anticipation in familial plasma cell dyscrasias

Deshpande

Marino

et al. 1998

Br J Haematol

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Summary. Familial myeloma was described as early as 1925; however, the causative factors are unknown. Studies of families with other familial haematological malignancies demonstrate anticipation. Five new families are described in which plasma cell dyscrasias occurred in parent and child generations (six such pairs), and data were pooled with those of 16 other families (with 20 parent-child pairs affected) recorded in the literature. Disease-free survival for parent and child generations were each estimated and differences in the disease-free survival between generations were tested by the log-rank and signed rank methods. In all six previously unreported parent-child pairs with plasma cell dyscrasia and in 18/20 such pairs found in the literature, the disease occurred at an earlier age in the child generation. The median age of onset of myeloma in the parent and child generations of all 26 pairs was 71 years (95% CI 67-78 years) and 50 years (95% CI 45-55 years), respectively (P < 0·0001). The ages of onset of malignant plasma cell dyscrasias in the parent and child generations of these families compared with patients in the general population were significantly different for the child generation (P < 0·005) but not for the parent generation. It would appear that anticipation occurs in familial myeloma.

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Section: Discussionmentioning

confidence: 99%

Anticipation in familial plasma cell dyscrasias

Deshpande

Marino

et al. 1998

Br J Haematol

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“…These findings suggest that the Cw2 allele, or a gene located in proximity to this locus, may confer susceptibility to the development of MM [11]. Reports of plasma and lymphocyte dyscrasias in siblings and other near relatives of MM patients suggest that the predisposition to the development of MM may be inherited [12,13].…”

Section: Introductionmentioning

confidence: 99%

IL-6 and IL-10 promoter gene polymorphisms do not associate with the susceptibility for multiple myeloma

et al. 2005

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“…In only one series has a significant increase of CW5 in black Americans been demonstrated (Leech & Bryan, 1983). In familial multiple myeloma we have described previously (Grosbois et al , 1986) an HLA identity in two brothers. Loth & Perrotta (1991) also reported HLA identity in two sisters.…”

Section: Discussionmentioning

confidence: 94%

“…Multiple myeloma in two members of the same family is a rare occurrence. In a previous report we described two cases with immunochemical and immunogenetic identity and emphasized the great value of such cases for improved understanding of the disease pathogenesis (Grosbois et al , 1986).…”

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confidence: 93%

Familial multiple myeloma: report of fifteen families

et al. 1999

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Summary.To further define the frequency, clinical and biological features of familial multiple myeloma we performed a retrospective study of related patients who presented with multiple myeloma. Most cases of familial multiple myeloma were observed in siblings (10/15), in whom the mean age at diagnosis was similar to unrelated multiple myeloma. In successive generations the mean age at diagnosis was lower. Monoclonal component was identical (IgG kappa) in seven families. Familial history of monoclonal gammopathy of undetermined significance was observed in three families. Five other prospective studies of 1263 patients identified four affected families (3·2 per 1000 cases of multiple myeloma), and raise the question of a genetic background in multiple myeloma.

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Multiple myeloma in two brothers. An immunochemical and immunogenetic familial study

Cited by 14 publications

References 32 publications

Anticipation in familial plasma cell dyscrasias

Anticipation in familial plasma cell dyscrasias

IL-6 and IL-10 promoter gene polymorphisms do not associate with the susceptibility for multiple myeloma

Familial multiple myeloma: report of fifteen families

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