Familial multiple myeloma: report of fifteen families

Grosbois, B.; Jégo, Patrick; Attal, Michel; Payen, Catherine; Rapp, Marie‐José; Fuzibet, J. G.; Maigre, M.; Bataille, Régis

doi:10.1046/j.1365-2141.1999.01415.x

Cited by 55 publications

(32 citation statements)

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“…There have been many reports of the familial occurrence of myeloma in the literature, implying a hereditary element or a common environmental factor [11][12][13][14][15][16]. Most of these families have been of Caucasian origin.…”

Section: Introductionmentioning

confidence: 99%

“…Brown et al [8] found that cigarette smoking and alcohol intake could not account for the disparity in the incidence rates. Other work has suggested that environmental factors such as exposure to pesticides and solvents or genetic factors such as translocations involving Chromosomes 13 and 14 may play a role [9,10].There have been many reports of the familial occurrence of myeloma in the literature, implying a hereditary element or a common environmental factor [11][12][13][14][15][16]. Most of these families have been of Caucasian origin.…”

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confidence: 99%

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Familial myeloma and monoclonal gammopathy: A report of eight African American families

2008

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Previous descriptions of familial myeloma have been mainly of Caucasian families. We report here eight African American families with familial multiple myeloma and monoclonal gammopathy identified over a 30 year period. Six patients with multiple myeloma (MM) and two with monoclonal gammopathy of unknown significance (MGUS) reported a family history of MM or had family members with MGUS found on screening. A pedigree compiled for each family included a history of other cancers. In the eight families, 21 of 58 first degree relatives had a plasma cell dyscrasia including 12 MM, eight MGUS, and one amyloidosis patient(s). The age of the MM patients ranged from 50 to 78 years (median 61 years). Four families had two members with MM, including one mother-son and three sibling pairs. Two MM families each had two additional first degree relatives with MGUS, with three generations involved in one family. Anticipation was suggested in two families with parent-child pairs with monoclonal gammopathy. The eight pedigrees had 66 members, 21 of whom had a diagnosis of cancer, including non-Hodgkin lymphoma and Hodgkin disease, or a clonal myeloproliferative disorder other than MM. Although the mode of genetic transmission and anticipation cannot be confirmed due to the small sample size, the increased number of MM and MGUS family members suggests underlying genetic susceptibility factors for plasma cell dyscrasias and possibly for other cancers in these families. Am. J. Hematol. 84:34-38, 2009. V V C 2008 Wiley-Liss, Inc. IntroductionMultiple myeloma (MM) is a progressive disease of malignant plasma cells causing 20% of the deaths due to hematologic malignancies [1]. A more common clonal plasma cell disorder is monoclonal gammopathy of unknown significance (MGUS) which occurs in 1-2% of the population over the age of 50 years and is associated with progression to malignant plasma cell disorders at a rate of 1% per year [2]. The incidence rate of MM is twice as high for African Americans (AAs) (11.3 per 100,000) when compared with Whites (5.1 per 100,000) [3]. Similarly, it has been shown that MGUS is found more frequently in AAs than in White individuals [4][5][6].Several studies have investigated possible reasons for the race-related differences in MM. Pottern et al. [7] showed an association between MM and the HLA-Cw2 allele; however, this allele was found in the same frequency in AA and Caucasian controls, suggesting other factors must play a role. Brown et al. [8] found that cigarette smoking and alcohol intake could not account for the disparity in the incidence rates. Other work has suggested that environmental factors such as exposure to pesticides and solvents or genetic factors such as translocations involving Chromosomes 13 and 14 may play a role [9,10].There have been many reports of the familial occurrence of myeloma in the literature, implying a hereditary element or a common environmental factor [11][12][13][14][15][16]. Most of these families have been of Caucasian origin. A recent study [16] investigated 39 MM...

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Familial myeloma and monoclonal gammopathy: A report of eight African American families

2008

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“…A familial occurrence of hematological malignancies like MM, non-Hodgkin's lymphoma and MDS has been described. 10,11,12 Of note is that in our series of patients, the donor and recipient in all three cases were diagnosed with the same hematological malignancy. This leads to the consideration that in addition to older donors particularly in donors with potential for familial malignancies more extensive screening investigations including serum protein electrophoresis and bone marrow aspiration may be reasonable.…”

Section: Cfu-gmmentioning

confidence: 66%

Bone marrow aspirates as part of routine donor assessment for allogeneic blood and marrow transplantation can reveal presence of occult hematological malignancies in otherwise asymptomatic individuals

Kiss

Chang

Daly

et al. 2004

Bone Marrow Transplant

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“…[45][46][47] There are several reports of the familial incidence of myeloma, the germline genetics of which have not been established. 48 There are a smaller number of reported instances of familial AL but no genetic studies have been performed on any of these very rare kindreds 49,50 Interestingly, a number of studies have reported that African-Americans have a higher frequency of multiple myeloma and examination of the Department of Veterans Affairs inpatient data base suggests that they also have a higher frequency of AL. 51 Similarly, an extensive autopsy series indicated that Hispanics of Mexican descent seemed to have a higher prevalence of both AL and AA, but neither observation has been confirmed by a formal epidemiologic study nor have they been subjected to genetic analysis; hence, the possibility remains that the effect may be environmental rather than genetic.…”

Section: Amyloidoses Derived From Molecules Involved In Immune Functionmentioning

confidence: 99%

The genetics of the amyloidoses: interactions with immunity and inflammation

Buxbaum

2006

Genes Immun

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Historically, the amyloidoses have been associated with inflammation and the immune response. From Virchow's original description in human pathologic inflammatory states through their identification in horses used to produce antitoxin to their frequent occurrence in the course of multiple myeloma and a somewhat abortive designation as 'gammaloid', the disorders were felt to have an inflammatory origin. These presumptive associations antedated the availability of a reliable method for tissue extraction that would allow chemical analysis of the major deposited molecules. With the identification of the multiple precursors and the realization that most were not intrinsic elements of immune/inflammatory pathways, the investigative emphasis shifted to the analysis of the biophysical events involved in aggregation and fibril formation. As more in vivo models and better tools for examination of tissues have become available, it appears as if inflammation may participate as both a response to, and an amplifier of, the effects of the fibrillar aggregates. Hence, while only a limited number of amyloid protein precursors are involved in immunity and inflammation per se, host defense, in its broadest sense, is likely to be involved in the clinically relevant amyloidoses. Further it now appears that harnessing the immune respone in an appropriate fashion may be able to play a role in treatment.

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Familial multiple myeloma: report of fifteen families

Cited by 55 publications

References 9 publications

Familial myeloma and monoclonal gammopathy: A report of eight African American families

Familial myeloma and monoclonal gammopathy: A report of eight African American families

Bone marrow aspirates as part of routine donor assessment for allogeneic blood and marrow transplantation can reveal presence of occult hematological malignancies in otherwise asymptomatic individuals

The genetics of the amyloidoses: interactions with immunity and inflammation

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