Genetic studies in multiple myeloma 1. Association with HLA-Cw5

Leech, Stephen H.; Bryan, Christopher; Elston, Robert C.; Rainey, John M.; Bickers, John N.; Pelias, Mary Z.

doi:10.1002/1097-0142(19830415)51:8<1408::aid-cncr2820510814>3.0.co;2-7

Cited by 27 publications

(9 citation statements)

References 13 publications

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“…More recently, associations have been found with the C locus, involving HLA‐Cw5, HLA‐Cw6 and HLA‐Cw2 antigens (Leech et al ., 1983; Pottern et al ., 1992). A significantly higher frequency of HLA‐Cw2 has been noted in both American blacks and white men (Pottern et al ., 1992).…”

Section: Discussionmentioning

confidence: 99%

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HLA class I and class II antigens associated with multiple myeloma in southern Africa

Patel

Wadee²,

Galpin

et al. 2002

Clinical &Amp; Laboratory Haematology

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While the exact aetiology of myeloma is unknown, genetic factors feature among the potential risk factors. The HLA phenotypes in African blacks with myeloma (the commonest haematopoietic malignancy in this group) have not been characterized. The purpose of this study was to determine the HLA class I and class II phenotypes of patients with multiple myeloma and to compare the findings to an ethnically matched control group of 100 individuals. Analysis of the HLA class I and class II phenotypes in 62 myeloma patients revealed: (i) a corresponding statistically significant association with HLA B18 [odds ratio (OR) 6.3; 95% confidence interval (CI) 1.013-39.727; P < 0.005]; (ii) no statistically significant association with HLA B13, Cw2, Cw6 or the DR and DQ antigens; and (iii) a statistically significant negative (protective) association with HLA Cw7 (OR 0.4; 95% CI 0.21-0.87; P < 0.005). This study suggests that although genetic factors may play a role in the multifactorial aetiology of multiple myeloma, with the exception of HLA B18, there is no specific association between HLA types and multiple myeloma in South African blacks.

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Section: Discussionmentioning

confidence: 99%

“…In American blacks, a strong association was found with the HLA‐Cw5 antigen (four of 22 cases compared to two of 138 controls; OR = 15; Leech et al ., 1983). All four myeloma cases with the Cw5 antigen were males.…”

Section: Discussionmentioning

confidence: 99%

HLA class I and class II antigens associated with multiple myeloma in southern Africa

Patel

Wadee²,

Galpin

et al. 2002

Clinical &Amp; Laboratory Haematology

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“…In an earlier study of HLAs in African Americans, HLA-Cw5 was associated with an increased risk of multiple myeloma. 333 A significant association was found for HLA-B18, but not for the other HLA types in an analysis of HLA class I and class II phenotypes in South African black myeloma patients. 334 Monoclonal gammopathy of undetermined significance MGUS denotes the presence of M-protein in persons without evidence of myeloma or related conditions; however, their risk of developing multiple myeloma is greatly increased.…”

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confidence: 94%

Multiple myeloma: A review of the epidemiologic literature

et al. 2007

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Multiple myeloma, a neoplasm of plasma cells, accounts for 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no established lifestyle, occupational or environmental risk factors. Although several factors have been implicated as potentially etiologic, findings are inconsistent. We reviewed epidemiologic studies that evaluated lifestyle, dietary, occupational and environmental factors; immune function, family history and genetic factors; and the hypothesized precursor, monoclonal gammopathies of undetermined significance (MGUS). Because multiple myeloma is an uncommon disease, etiologic assessments can be difficult because of small numbers of cases in occupational cohort studies, and few subjects reporting exposure to specific agents in case-control studies. Elevated risks have been reported consistently among persons with a positive family history of LHC. A few studies have reported a relationship between obesity and multiple myeloma, and this may be a promising area of research. Factors underlying higher incidence rates of multiple myeloma in African Americans are not understood. The progression from MGUS to multiple myeloma has been reported in several studies; however, there are no established risk factors for MGUS. To improve our understanding of the causes of multiple myeloma, future research efforts should seek the causes of MGUS. More research is also needed on the genetic factors of multiple myeloma, given the strong familial clustering of the disease. ' 2007 Wiley-Liss, Inc.Key words: multiple myeloma; epidemiology Multiple myeloma is a malignancy of plasma cells that results in an overproduction of light and heavy chain monoclonal immunoglobulins. The specific immunoglobulin secreted by the malignant cell is the M-protein, named in reference to its monoclonal characteristics. It is found in the serum and/or urine of persons affected with multiple myeloma.

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“…Most of the HLA‐typing studies in unrelated multiple myeloma have not shown significant association with the major histocompatibility complex markers. In only one series has a significant increase of CW5 in black Americans been demonstrated (Leech & Bryan, 1983). In familial multiple myeloma we have described previously (Grosbois et al , 1986) an HLA identity in two brothers.…”

Section: Discussionmentioning

confidence: 99%

Familial multiple myeloma: report of fifteen families

et al. 1999

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Summary.To further define the frequency, clinical and biological features of familial multiple myeloma we performed a retrospective study of related patients who presented with multiple myeloma. Most cases of familial multiple myeloma were observed in siblings (10/15), in whom the mean age at diagnosis was similar to unrelated multiple myeloma. In successive generations the mean age at diagnosis was lower. Monoclonal component was identical (IgG kappa) in seven families. Familial history of monoclonal gammopathy of undetermined significance was observed in three families. Five other prospective studies of 1263 patients identified four affected families (3·2 per 1000 cases of multiple myeloma), and raise the question of a genetic background in multiple myeloma.

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Genetic studies in multiple myeloma 1. Association with HLA-Cw5

Cited by 27 publications

References 13 publications

HLA class I and class II antigens associated with multiple myeloma in southern Africa

HLA class I and class II antigens associated with multiple myeloma in southern Africa

Multiple myeloma: A review of the epidemiologic literature

Familial multiple myeloma: report of fifteen families

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