ALK1 expression and MVD are increased in OLP, particularly in A/ELP type.

No abstract

Purpose:The extent of invasion can be analyzed by the expression and production of various genes and proteins by lesional cells. However, current clinical parameters lack the potential to predict the neoplastic behavior in solid ameloblastoma (SAB) and odontogenic keratocyst (OKC). Cortactin, an F-actin binding protein, overexpression has been correlated with advanced clinic pathological stage and poor prognosis in several tumors. E-cadherin belongs to the classical cadherins which. Low E-cadherin expression correlated to aggressive, poorly differentiated, high-grade carcinomas and low patient survival. Human-murine double minute 2 (MDM2), contributes to the promotion of cell growth, survival, invasion, and therapeutic resistance, overexpression of MDM2 has been observed in various human cancers and can contribute to genomic instability, thus, further promoting tumorigenesis. The purpose of this work was to investigate the role of Cortactin, E-Cadherin, MDM2 proteins expression in SAB and OKC and correlate the expression of these markers with the aggressive behavior of these tumors. Material and method: 10 case of solid ameloblastoma with its different histologic variants and 10 cases of the keratocystic odontogenic tumor were collected as paraffin embedded blocks. An immunohistochemical investigation using, Cortactin, E-Cadherin, and MDM2 antibodieswere done for all specimens. Results: The mean area percent of immunoexpression of Cortactin was greatest in SAB while, the mean area percent of immunoexpression of E-Cadherin, MDM2 were greatest in OKC. Conculsion:According to the current study, the absence of any significant differences between AB and OKC indicate the neoplastic and aggressive nature of OKC similar to AB.

No abstract

Purpose:The purpose of this work stayed to evaluate the expression of GRP78 as a prognostic indicator of aggressiveness in tumors of the salivary gland and to relate its expression with the salivary gland tumors biological behavior. Material and Method: 80 cases of salivary gland tissues were collected as paraffin embedded blocks: 30 benign cases (15 pleomorphic adenoma and 15 Warthin's tumors) and 45 malignant cases (15 carcinoma ex pleomorphic adenomas, 15 mucoepidermoid carcinomas in addition to 15 adenoid cystic carcinoma). Additionally, 5 normal salivary gland tissues. Using GRP78 antibody, an immunohistochemical investigation was done for all specimens. Results: The greatest mean area percent of GRP78 immunoexpressioin was in malignant variants of salivary gland tumors, followed by benign variants of salivary gland tumors and the least value recorded in normal salivary gland tissue. Conclusion: According to the current study, GRP78 is considered as a useful marker for diagnosis of malignancy of salivary gland. Codex : 35/1907 azhardentj@azhar.edu.eg