Expression of MMP-1 and MMP-9 in Localized Aggressive Periodontitis Patients Before and After Treatment: A Clinical and Immunohistochemical Study

Hazzaa, Hala H.; Hager, Eman A. Abo

doi:10.21608/edj.2017.75015

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…nTIMP1 inhibits nMMP-9, which was identified in neuronal cells, and exhibits insignificant or low levels of nMMP-9-derived gelatinase activity [ 80 , 81 , 87 ]. nTIMP1 was detected in gingival fibroblasts (in which nMMP-1 and nMMP-9 were later identified), and also in breast carcinoma cells, where nMMP-1 was also subsequently identified [ 23 , 24 , 76 , 77 ]. The mechanistic relationship shared between nMMPs and nTIMPs based upon them simultaneously residing in the nucleus have not been fully investigated in model systems, but immunofluorescence analysis has indicated nMMP/nTIMP co-localization within the nucleus of neural stem cells in Huntington’s disease (HD) can contribute to enhanced neurotoxicity.…”

Section: Mechanistic Regulation Of Nuclear Mmpsmentioning

confidence: 99%

Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design

Frolova

Petushkova

Макаров

et al. 2020

Biology

View full text Add to dashboard Cite

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for the degradation of a wide range of extracellular matrix proteins, which are involved in many cellular processes to ensure the normal development of tissues and organs. Overexpression of MMPs has been observed to facilitate cellular growth, migration, and metastasis of tumor cells during cancer progression. A growing number of these proteins are being found to exist in the nuclei of both healthy and tumor cells, thus highlighting their localization as having a genuine purpose in cellular homeostasis. The mechanism underlying nuclear transport and the effects of MMP nuclear translocation have not yet been fully elucidated. To date, nuclear MMPs appear to have a unique impact on cellular apoptosis and gene regulation, which can have effects on immune response and tumor progression, and thus present themselves as potential therapeutic targets in certain types of cancer or disease. Herein, we highlight and evaluate what progress has been made in this area of research, which clearly has some value as a specific and unique way of targeting the activity of nuclear matrix metalloproteinases within various cell types.

show abstract