<scp>ALK</scp>1 expression in oral lichen planus: a possible relation to microvessel density

Hazzaa, Hala H.; El-Wakeel, N.; Attia, Enas A. S.; Hager, Eman A. Abo

doi:10.1111/jop.12396

Cited by 8 publications

(26 citation statements)

References 40 publications

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“…Additionally, MVD in OLP tissue increased with the deterioration of the lesion. Previous results, together with those from the present study, indicated that increased angiogenesis may serve a vital role in the malignant transformation of OLP (29,30). However, the mechanism underlying this phenomenon remains unclear.…”

Section: Discussionsupporting

confidence: 66%

Interleukin‑6 released by oral lichen planus myofibroblasts promotes angiogenesis

Liu

et al. 2021

Exp Ther Med

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Oral lichen planus (OLP), defined as a potential for malignant transformation, is a chronic inflammatory disease in which abnormal angiogenesis serves a role in the malignant changes of the disease. OLP-associated fibroblasts (OLP-MFs), derived from the stroma of OLP tissues, are characterized by the presence of myofibroblasts and contribute to the secretion of pro-inflammatory cytokines, which may be involved in the molecular pathogenesis of OLP. However, the associated mechanisms of angiogenesis in OLP remain unknown. The present study aimed to verify the expression of intercellular adhesion molecular 1, vascular cell adhesion molecule 1, VEGF and CD34 in OLP, and to investigate whether IL-6 secreted by OLP-MFs promoted OLP angiogenesis and the effect of its corresponding antibody inhibition. The results of the experiments demonstrated that inflammation was present and OLP upregulated the secretion of IL-6 by OLP stromal fibroblasts, thereby enhancing OLP angiogenesis. Anti-IL-6 receptor antibody inhibited OLP-stroma IL-6 signaling and suppressed OLP angiogenesis. The antibody inhibited the inflammatory response by inhibiting the secretion of inflammatory factors, including IL-6, to suppress angiogenesis and reduce disease progression, thus indicating that this could be a potential target to develop a treatment for OLP.

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Section: Discussionsupporting

confidence: 66%

Interleukin‑6 released by oral lichen planus myofibroblasts promotes angiogenesis

Liu

et al. 2021

Exp Ther Med

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“…[ 16 ] and Hazzaa et al . [ 32 ] These observations suggested that angiogenesis is one of the key contributing factors in the progression of OLP.…”

Section: Discussionmentioning

confidence: 99%

Horoscopic role of CD105 (Endoglin) in progression of oral lichen planus: An immunohistochemical study

Parvathala

Baghirath

Reddy

et al. 2021

J Oral Maxillofac Pathol

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Context: Role of CD105(Endoglin) in Pathogenesis and progression of OLP. Aim: To assess the role of neoangiogenesis in the progression of OLP by determining the expression of CD105 in OLP and normal mucosa. Settings and Design: The present study includes a total of 70 formalin-fixed paraffin-embedded blocks of which the study group comprises 50 tissue sections histopathologically confirmed as OLP. They were subdivided into two groups - Group I (Reticular OLP) and Group II (Erosive OLP) - 25 each. The control group (designated as Group III) included 20 sections of normal mucosa. Materials and Methods: All the sections were 4 μm thick and stained with CD105 antibodies. After identifying areas of highest vascularity (hot spots) in low power (×10) magnification, individual microvessels were counted manually at high power (×40) magnification. Statistical Analysis Used: Analysis of variance test was used to determine the difference of microvessel density (MVD) between variants of OLP and normal mucosa and Cohen's kappa statistic was used to check interobserver variability. Results: CD105 staining showed a mean MVD of 1.31 ± 1.8 in the normal mucosa compared to 1.68 ± 1.4 and 4.14 ± 2.7 in the reticular and erosive variants, respectively, with a P = 0.000*, which is statistically significant (*P < 0.05 is statistically significant). Conclusion: Based on our observations, it is evident that compared to normal mucosa, MVD is greater in lichen planus. Within the two variants of OLP, MVD is higher in Erosive variant compared with Reticular variant, foreshadowing the role of neoangiogenesis in the progression of OLP and its possible malignant transformation.

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“…endothelial growth factor correlated closely with the different clinical forms of OLP regions [13,37,38]. Mittal, et al suggested that angiogenesis was significantly increased in OLP as compared to normal oral mucosa, and also in erosive OLP as compared to reticular OLP; this suggests angiogenesis as a main contributing factor in the progression of OLP [13].…”

Section: Evaluation Of Average Areas and Ipcl Anglesmentioning

confidence: 92%

Histomorphometric Evaluation of Intraepithelial Papillary Capillaries in Oral Lichen Planus: A Histopathological Study

Hara¹,

Sakamaki²,

Higuchi³

et al. 2018

J Dermatol Res Ther

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Background: Definitive diagnosis of oral lichen planus (OLP) is important for planning treatment. The problems and difficulties of diagnosing OLP based on histopathological features were showing inter-and intra-observer variability. In terms of pathological diagnosis on OLP, microvascular appearance was not highly valued. Comparative histomorphometric analysis of intraepithelial papillary capillary loops (IPCLs) of OLP was performed to investigate the potential for use as diagnostic criteria. Methods: Immunohistochemical and histopathological evaluations of microvascular morphology were performed in 42 cases diagnosed as OLP clinico-histopathologically. Average areas and capillary loop angles at the sites adjacent to the lesion and most prominent and erosive areas of OLP were measured using image analysis software under microscopic observation. Results: Area of IPCLs in sites adjacent to the lesion was larger than those in prominent areas of OLP (p < 0.001). Capillary loop angles were 26.6 ± 19.3*, 84.5 ± 17.8*, 30.2 ± 2.4* and 34.4 ± 19.3* for normal mucosa, sites adjacent to the lesion, prominent areas of OLP, and erosive areas, respectively. Significant differences were observed between the prominent areas and adjacent sites to the lesion (p < 0.001). Conclusions: Characteristic IPCL patterns were identified in the present study despite reticular/erosive type. This research thus suggested the utility of these patterns in pathological diagnostic criteria.

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ALK1 expression in oral lichen planus: a possible relation to microvessel density

Abstract: ALK1 expression and MVD are increased in OLP, particularly in A/ELP type.

Cited by 8 publications

References 40 publications

Interleukin‑6 released by oral lichen planus myofibroblasts promotes angiogenesis

Interleukin‑6 released by oral lichen planus myofibroblasts promotes angiogenesis

Horoscopic role of CD105 (Endoglin) in progression of oral lichen planus: An immunohistochemical study

Histomorphometric Evaluation of Intraepithelial Papillary Capillaries in Oral Lichen Planus: A Histopathological Study

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