Assessment of Anti-carcinogenic Effect of Pomegranate in Oral Squamous Cell Carcinoma (Pre-clinical Study)

Morsy, Reham A.A.; Abbass, Effat A.; Hager, Eman A. Abo; Farid, Mohamed; Ellithy, Marwa M; Azmy, Aliaa

doi:10.3923/pjbs.2019.580.584

Cited by 3 publications

(4 citation statements)

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“…A total of seven articles were included in the scoping review: Weisburg et al, 2010 [ 40 ], Morsy et al, 2019 [ 41 ], Peng et al, 2021 [ 42 ] Peng Et al., 2020, [ 43 ], Gao et al, 2022 [ 44 ], Seeram et al, 2005 [ 45 ]; Kasimsetty et al, 2010 [ 46 ]. All studies were in vitro (cell line studies).…”

Section: Resultsmentioning

confidence: 99%

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Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review

et al. 2022

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The Punica granatum L. is an ancient fruit plant native to south-western Asia. It belongs to the Litraceae family and of its genus we have only one other Punica protopunic species. The fruit is rich in polyphenols, whose extract is consumed as a food and is considered safe. In medicine, it is used for its antioxidant properties; it has a rich component of tannic polyphenols among which the most bioactive are: punicalagin (flavonoids) and anthocyanins (delphinidin, cyanidin, pelargonidin), which are found mainly in the skins and in the pericarp; however, all the parts of the Punica granatum are used for therapeutic purposes as anti-inflammatories and analgesics and in diabetes and cardio-vascular disease. Punica granatum extracts also show interesting anticancer activities in influencing tumorgenesis and angiogenesis and cell transformation and proliferation. The purpose of this scoping review is to summarize all the scientific evidence on the possible applications of Punica granatum extracts in the treatment and prevention of oral cavity tumors to investigate the anticancer properties of the active ingredients extracted from Punica granatum. Methods: The scoping review was carried out following the PRISMA-ScR checklist; the search was performed on three databases (Scopus, Science direct and PubMed) and one registry (Cochrane library). Results: The search produced a number of bibliographic sources equal to 11,403; with the removal of duplicates, 670 potentially admissible articles were obtained, from 24 of which only 7 in vitro studies on OSCC cell lines were included. Conclusions: From the preliminary data on the cellular lines of OSCC, it emerges that for oral cancer there are conditions for which the extracts of Punic granatum are effective at least from a prevention perspective.

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Section: Resultsmentioning

confidence: 99%

“…As an alternative to the powder usually supplied in capsules, the second main formulation used is POM (Wonderful, LLC, Los Angeles, California) [ 45 ] or more generally pomegranate juice [ 46 ], or some main elagittannins (punicalagin) contained in the extracts as in Morsy et al, 2019 [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review

et al. 2022

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“…Additionally, in the literature reviewed in the present contribution, the variety of pharmaceutical forms prepared with pomegranate, such as gel, mouthwash, mouthwash with silver nitrate nanoparticles, chewable tablets, silver nitrate nanoparticles, and aerosol [ 89 , 92 , 95 , 102 , 104 , 120 ], indicates that pomegranate can be manipulated without complications in order to elaborate the necessary pharmaceutical form according to the needs of patients. Regarding anti-oral candidiasis treatment, it still faces some challenges due to the humidity and surface tension of the oral mucosa that makes the adhesion to surfaces difficult.…”

Section: Discussionmentioning

confidence: 99%

Punica granatum as Anticandidal and Anti-HIV Agent: An HIV Oral Cavity Potential Drug

Huerta-Reyes

Gaitán-Cepeda

Sánchez-Vargas

2022

Plants

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The oral cavity is crucial from diagnosis to adherence to HAART therapy in the HIV/AIDS population; consequently, drugs that can maintain healthy conditions in the oral cavity are necessary for patients with HIV/AIDS. Punica granatum (pomegranate) is a tree that has been employed extensively for centuries in the traditional medicine of ancient cultures for the treatment of a wide range of diseases, including oral and dental diseases. In recent decades, its potent anticandidal properties have been shown, especially on Candida albicans, the cause of the most common clinical manifestation in HIV patients. The present work contributes to the review of the anti-HIV and anticandidal properties of the plant species P. granatum as involved with the oral cavity. The literature reviewed revealed that crude extracts of pomegranate and its main isolated compounds possess inhibitory activity on different HIV targets, including binding viral proteins and the three replicative HIV enzymes. In addition, in the literature reviewed, pomegranate exhibited anticandidal effects on 10 different species. Thus, pomegranate appears to be an excellent candidate to explore and incorporate into the treatment of the oral cavity of HIV/AIDS patients, in that, in addition to its pharmacological effects such as antiviral and anticandidal, pomegranate represents an easily available, inexpensive, and safe natural source.

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“…Punicalagin (PUN, Supplementary Figure S1 ), which is the main active ingredient of pomegranate ( Punica granatum L.) peel, possesses multiple bioactivities, such as antioxidant ( Chen et al, 2012 ), antibacterial ( Sun Q. et al, 2019 ) and anti-tumor ( Morsy et al, 2019 ; Huang et al, 2020 ; Pan et al, 2020 ) activities. Intriguingly, the regulatory effects of punicalagin on suppressing inflammation have attracted the researcher’s attention.…”

Section: Introductionmentioning

confidence: 99%

Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion

Tang

Zhang

et al. 2022

Front. Pharmacol.

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Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate (Punica granatum L.) peel with multiple biological activities, such as antibacterial, antioxidant and anti-tumor effects. However, the potential effect of PUN on psoriasis remains unknown. In this study, we want to investigate the pharmacological effect of PUN on psoriasis by using imiquimod (IMQ)-induced psoriatic mice model in vivo and tumor necrosis factor a (TNF-α) and interleukin-17A (IL-17A)-stimulated HaCaT cells in vitro. Our results showed that PUN can effectively alleviate the severity of psoriasis-like symptoms. Mechanistically, PUN potently suppresses the aberrant upregulation of interleukin-1β (IL-1β) and subsequent IL-1β-mediated inflammatory cascade in keratinocytes by inhibiting the nuclear factor kappa B (NF-κB) activation and cleaved caspase-1 expression in vitro and in vivo. Taken together, our findings indicate that PUN can relieve psoriasis by repressing NF-κB-mediated IL-1β transcription and caspase-1-regulated IL-1β secretion, which provide evidence that PUN might represent a novel and promising candidate for the treatment of psoriasis.

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Assessment of Anti-carcinogenic Effect of Pomegranate in Oral Squamous Cell Carcinoma (Pre-clinical Study)

Cited by 3 publications

References 12 publications

Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review

Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review

Punica granatum as Anticandidal and Anti-HIV Agent: An HIV Oral Cavity Potential Drug

Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion

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