No abstract

This study was conducted to examine the potential of cuttlebone xenograft in the healing of bone using radiography and histology for a period of 24 weeks. One hundred and five New Zealand male rabbits with radius defects in the metaphyseal region were divided into five groups treated with cuttlebone, demineralized bone matrix, bovine cancellous graft, and tricalcium phosphate. The control was no treatment. Clinical, radiological, biochemical and histological evaluations were made 1, 2, 3, 4, 6, 12, and 24 weeks after surgery. Physiological measurements (body temperature, heart rate, and respiratory rate) were not affected by the treatments. The radiological score was greatest in the demineralised bone matrix and tricalcium phosphate groups (score of 8), followed by the bovine cancellous graft (score of 6), cuttlebone (score of 6), and control groups (score of 5). The histological score was greatest in the tricalcium phosphate group (score of 55), followed by the cuttlebone (score of 50), bovine cancellous graft (score of 48), demineralized bone matrix (score of 44) and control groups (score of 42). Oxidative enzyme activities were not different across the treatments. The lack of reinfection and infection responses and faster bone union highlight the potential of cuttlebone xenograft in orthopaedic surgery.

No abstract

P2X7 receptors (P2X7Rs) are ATP sensitive cation channels and have been shown to be effective in various epilepsy models. Absence epilepsy is a type of idiopathic, generalized, non-convulsive epilepsy. Limited data exist on the role of P2X7Rs and no data has been reported regarding the interaction between P2X7Rs and glutamate receptor NMDA in absence epilepsy. Thus, this study was designed to investigate the role of P2X7 and NMDA receptors and their possible interaction in WAG/Rij rats with absence epilepsy. Permanent cannula and electrodes were placed on the skulls of the animals. After the healing period of the electrode and cannula implantation, ECoG recordings were obtained during 180 min before and after drug injections. P2X7R agonist BzATP, at doses of 50 µg and 100 µg (intracerebroventricular; i.c.v.) and antagonist A-438079, at doses of 20 µg and 40 µg (i.c.v.) were administered alone or prior to memantine (5 mg/kg, intraperitoneal; i.p.) injection. The total number (in every 20 min), the mean duration, and the amplitude of spike-wave discharges (SWDs) were calculated and compared. Rats were decapitated and the right and left hemisphere, cerebellum, and brainstem were separated for the measurements of the advanced oxidation protein product (AOPP), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), glutathione peroxide (GPx), and glutathione reductase (GR). BzATP and A-438079 did not alter measured SWDs parameters, whereas memantine reduced them, which is considered anticonvulsant. BzATP did not alter the anticonvulsant effect of memantine, while A-438079 decreased the effect of memantine. Administration of BzATP increased the levels of SOD and GR in cerebrum hemispheres. A-438079 did not alter any of the biochemical parameters. Memantine reduced the levels of MDA, GSH, and GR while increased the level of CAT in the cerebrum. Administration of BzATP before memantine abolished the effect of memantine on MDA levels. The evidence from this study suggests that P2X7Rs

ZT combination did not have a significant effect on IOP in cats, when administered by IM or IN routes.

The aim of this research was to compare rectal, eye and ear temperature of 30 healthy Kangal dogs. Rectal temperature was measured by use of standard rectal digital thermometer. Right and left eye temperatures were detected by infrared thermal camera from the carancula lacrimalis region. Tympanic thermometer was used to determine right and left ear temperatures. Data were analyzed by Pearson correlation test. The comparative analysis showed no significant differences between the measurement methods. Measuring of ear and eye temperature could be an alternative method to obtain body temperature in Kangal dogs. Keywords: Body temperature, Rectal temperature, Eye, Ear, Kangal dog Kangal Irkı Köpeklerde Kulak, Göz ve Rektal Isıların Karşılaştırılması ÖzetBu çalışmanın amacı 30 sağlıklı kangal köpeğinin kulak, göz ve rektal ısılarını karşılaştırmaktı. Rektal ısı standart digital rektal termometre kullanılarak ölçüldü. Sağ ve sol göz ısısı carancula lacrimalis bölgesinden kızılötesi termal kamera ile belirlendi. Timpanik termometre sağ ve sol kulak ısı değerlerini belirlemede kullanıldı. Veriler Pearson korelasyon testi ile analiz edildi. Karşılaştırmalı analizler tüm metodlar arasında önemli bir farklılık olmadığını gösterdi. Kangal köpeklerinde kulak ve göz ısısının ölçülmesi, vücut ısısının belirlenmesi için alternatif bir yöntem olabilir.

Graphical abstract

A fasting duration of ~ 17 hours a day did not affect renal function negatively in patients with early-stage chronic kidney disease due to ADPKD. Also, no significant changes occurred in acute renal failure markers.
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