Cardiovascular disease and toxic metals

Sevim, Çiğdem; Doğan, Elif; Çomaklı, Selim

doi:10.1016/j.cotox.2020.01.004

Cited by 35 publications

(14 citation statements)

References 40 publications

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“…On the contrary, chromium (Cr), rubidium (Rb), and barium (Ba) were found at higher levels in controls’ serum; the difference was statistically significant ( p > 0.05) only in the case of Cr though ( Figure 3 , Table S3 ). Recent reviews have highlighted the association of both known toxic and essential metals with CVDs development [ 77 , 78 ]; thus, the elements that were observed with significantly different concentrations in cases’ or control’s serum will be separately discussed.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, Cd and Pb compete with the essential Zn, as they have similar physicochemical properties, for the binding sites of enzyme proteins [ 134 ]. As a result, the strong relation among some specific metals can be indicative of a similar mechanism, although the metal-induced cardiotoxicity mechanisms vary widely, and there is still a great matter of research [ 77 ]. Interestingly, the PCA that refers to the controls’ samples is completely different, with mixed factors and less significant correlations, supporting the hypothesis that PAHs and trace elements constitute a notable factor of heart failure development.…”

Section: Resultsmentioning

confidence: 99%

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Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

et al. 2021

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Cardiovascular diseases (CVDs) have been associated with environmental pollutants. The scope of this study is to assess any potential relation of polycyclic aromatic hydrocarbons (PAHs), their hydroxylated derivatives, and trace elements with heart failure via their direct determination in human serum of Greek citizens residing in different areas. Therefore, we analyzed 131 samples including cases (heart failure patients) and controls (healthy donors), and the respective demographic data were collected. Significantly higher concentrations (p < 0.05) were observed in cases’ serum regarding most of the examined PAHs and their derivatives with phenanthrene, fluorene, and fluoranthene being the most abundant (median of >50 μg L−1). Among the examined trace elements, As, Cd, Cu, Hg, Ni, and Pb were measured at statistically higher concentrations (p < 0.05) in cases’ samples, with only Cr being significantly higher in controls. The potential impact of environmental factors such as smoking and area of residence has been evaluated. Specific PAHs and trace elements could be possibly related with heart failure development. Atmospheric degradation and smoking habit appeared to have a significant impact on the analytes’ serum concentrations. PCA–logistic regression analysis could possibly reveal common mechanisms among the analytes enhancing the hypothesis that they may pose a significant risk for CVD development.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

et al. 2021

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“…The adverse effects might impact humans in a long-term manner as dietary fish consumption (Ling and Liao, 2007). Heavy metal accumulation in the human body is associated with various health implications, including cancers (Saher and Kanwal, 2019), CVD (Sevim et al, 2020), hypertension (Martins et al, 2021), diabetes (Javaid et al, 2021), brain damage (Paithankar et al, 2021), disruption of immune function and impaired gastrointestinal system (Yu et al, 2021b), andanemia (Ashley-Martin et al, 2021). More importantly, pregnant women who were exposed to these toxic metals might experience miscarriage, stillbirth, premature birth, low birth weight, and fetal malformations (WHO, 2016).…”

Section: Heavy Metalsmentioning

confidence: 99%

Insight Into the Relation Between Nutritional Benefits of Aquaculture Products and its Consumption Hazards: A Global Viewpoint

2022

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Aquaculture plays a huge role in supporting the needs and demands of fish and other aquatic organisms globally. Being a vital contributor in the fisheries sector, aquatic sources derived from the aquaculture industry are well-known for their high nutritive values that are compromised with high-quality protein, essential omega-3 fatty acids, vitamins, and minerals. Aquaculture has also widened fish availability to regions and countries with limited access to farmed species, leading to improved nutrition and food security. However, the presence of dangerous contaminants, notably heavy metals, endocrine disrupting compounds, polycyclic aromatic hydrocarbons, microplastics, as well as antimicrobial drug residues, has been detected in the aquaculture products. In conjunction, the risk–benefit assessment (RBA) approach has been proposed to be used as a meaningful tool for evaluating the health impacts of the consumption of aquatic sources on the targeted population. This narrative review outlines a compilation of aquaculture products as a nutritional source for human consumption. The aquaculture industry is well-appreciated, especially in low-income countries, for achieving sustainable food security. The organoleptics and preferences of aquaculture products as means of dietary variations were demonstrated. The damaging contaminants contained in the commercially available aquaculture products were quantitatively outlined. Furthermore, the adaptation of the risk–benefit approach underlying its potent impacts on public health concerns, with its current challenges and limitations, is elucidated.

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“…Exposure to toxic metals such as As, Cd, Pb, Hg is associated with an increased risk of diabetes, atherosclerosis, cardiac arrest and hypertension, which are risk factors for cardiovascular disease (CVD) [ 43 , 44 ]. These metals increase the risk of CVD by inducing endocrine disruptions and creating reactive oxygen species in the myocytes of the heart [ 43 , 44 , 45 ]. Toxic metals are characterized by oxidizing abilities.…”

Section: Toxic Effects Of Metalsmentioning

confidence: 99%

Disorders of the Reproductive Health of Cattle as a Response to Exposure to Toxic Metals

Wrzecińska

Kowalczyk

Cwynar

et al. 2021

Biology

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The aim of this review is to comprehensively present disorders of the reproductive system in cattle exposed to contact with toxic metals. Toxic metals are a common environmental pollutant and can come from mines, smelters, fossil fuel combustion, or volcanic eruptions. Metals have the ability to bioaccumulate in living organisms, thus contaminating the food chain and may pose a threat to humans. They accumulate mainly in the liver and kidneys, but also in muscles and fat tissue. Toxic metals such as lead (Pb), arsenic (As), mercury (Hg), and cadmium (Cd) have a negative impact on the fertility of animals; they can lead to abortions, premature calving, or oocyte dysfunction. Moreover, in the male reproductive system, they disrupt spermatogenesis, and cause apoptosis of sperm and oxidative damage. The main source of exposure of livestock to toxic metals is through the consumption of feed or contaminated water. It is important to monitor the level of heavy metals in animal products to prevent human poisoning. Toxic metal biomonitoring can be performed by testing urine, blood, milk, plasma, or hair. Chromium (Cr), arsenic (As), and cadmium (Cd) are excreted in the urine, while lead can be detected by examining the blood of animals, while in milk, arsenic (As), cadmium (Cd), nickel (Ni), and lead (Pb) can be detected. Moreover, toxic metals do not biodegrade in the environment. To purify soil and waters, remediation methods, e.g., biological or chemical, should be used.

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Cardiovascular disease and toxic metals

Cited by 35 publications

References 40 publications

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

Insight Into the Relation Between Nutritional Benefits of Aquaculture Products and its Consumption Hazards: A Global Viewpoint

Disorders of the Reproductive Health of Cattle as a Response to Exposure to Toxic Metals

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