Background: Covid-19, caused by a new type of coronavirus named SARS-CoV-2, has become a pandemic. Together with SARS-CoV and MERS-CoV, Covid-19 is a large global outbreak of coronavirus infection; however, its rate of spread is much higher. Since the vaccines and anti-SARS-CoV-2 have not been found, a faster control mechanism is needed. Traditional herbs have shown the potential for this purpose, as has been demonstrated by the Chinese Government with a high success rate. One of the herbs used was Lindera aggregata, which is part of the collection in Purwodadi Botanic Garden. Objectives: Through in silico study, this research aims to reveal the secondary metabolites contained in L. aggregata that have the potential to serve as anti-SARS-CoV-2 medication as well as showcase their inhibitory mechanisms. Methods: The research was conducted through molecular docking analysis of terpenoids and alkaloids contained in the root of L. aggregata, with target proteins 3CLpro, PLpro, Spike, and ACE 2 playing a role in SARS-CoV-2 infection. Result: All analyzed compounds tended to interact with all four target proteins with different binding affinity values, but the interaction seemed stronger with 3CLpro and Spike. Terpenoids, linderane and linderalactone, had the strongest interaction tendency with 3CLpro, PLpro, and Spike; the compound norboldine, an alkaloid, had the strongest interaction with ACE 2, with a binding affinity value of -8.2 kcal/mol. Conclusion: Terpenoids and alkaloids contained in the root of L. aggregata, which caused inhibition of adsorption and replication of SARS-CoV-2, could serve as anti-SARS-CoV-2.
Purwodadi Botanic Garden (KR Purwodadi) is an ex situ conservation institution for dry climate lowland plants aiming at saving and protecting biodiversity from extinction. In supporting ex situ conservation efforts, plant exploration activities in their natural habitat need to be carried out. Alas Purwo National Park has a lowland forest area with abundant plant diversity. In addition to functioning as a conservation forest, this area is also a natural and religious tourist attraction, so it is likely to undergo ecosystem damage. Therefore, this plant diversity study with the activity of plants exploration and collection was carried out for the purpose of ex situ conservation in KR Purwodadi. This study was conducted in August to September 2019 using an explorative method. A total of 24 species were obtained, of which 8 species were not yet cultivated by KR Purwodadi. Besides, there were 5 species included in the IUCN red list, namely Aglaonema simplex, Brucea javanica, Cycas rumphii, Melanolepis multiglandulosa, and Musa acuminata. This study has increased the number of plant collections in KR Purwodadi and contribute positively to the comprehensiveness of plant species data in Alas Purwo National Park.
<p>Tumbuhan telah dikenal sebagai sumber obat alami yang dapat menyembuhkan berbagai macam penyakit karena mengandung senyawa metabolit sekunder dengan aktivitas biomedik. Tumbuhan paku merupakan kelompok tumbuhan tertua di bumi yang memiliki lebih dari 12.000 jenis. Tumbuhan paku mengandung senyawa metabolit sekunder yang berpotensi obat berdasarkan<br />studi etnobotani dan farmakologi. Sebanyak 20 suku dan 38 marga tumbuhan paku dikoleksi dan dikonservasi secara ex situ oleh Kebun Raya (KR) Purwodadi. Nephrolepis merupakan salah satu marga dari koleksi tumbuhan paku KR Purwodadi dengan jumlah spesimen paling banyak. Nephrolepis termasuk kelompok tumbuhan paku epifit atau setengah epifit yang daunnya tersusun<br />menyirip tunggal seperti pedang. Selama ini Nephrolepis hanya dikenal sebagai bahan sayuran dan tanaman hias oleh masyarakat. Namun belum ada informasi mengenai potensi obat dari koleksi Nephrolepis tersebut. Oleh karena itu, penelitian ini dilakukan untuk menginventarisasi dan mengarakterisasi potensi koleksi Nephrolepis di KR Purwodadi sebagai tanaman obat. Metode yang<br />digunakan pada penelitian ini adalah inventarisasi data dari Sistem Informasi Katalog Koleksi Tanaman (SIKATAN), pengamatan langsung di rumah kaca, dan studi etnomedisin dan fitokimia berdasarkan literatur. Berdasarkan hasil inventarisasi, telah diperoleh 36 spesimen yang termasuk dalam 6 jenis Nephrolepis. Spesimen tersebut memiliki potensi mengobati berbagai macam penyakit, baik yang telah dikenal dalam pengobatan tradisional maupun dari hasil penelitian. Koleksi Nephrolepis tersebut mengandung berbagai senyawa, seperti alkaloid, flavonoid, dan terpenoid yang memiliki aktivitas farmakologi, di antaranya antioksidan, antiinflamasi, antimikroba, antivirus, dan antikanker. Di samping itu, jenis N. cordifolia merupakan koleksi yang paling potensial<br />sebagai obat karena bagian daun, rimpang, hingga umbinya memiliki aktivitas antiinflamasi, antimikroba, antikanker, antimalaria, dan antioksidan.</p>
BromoTenggerSemeruNationalPark(BTSNP)isoneofnaturalconservationareasinEastJavawitharound1,025plantspecies.Impatiensplatypetala,locallyknownaspacartere,isaplantspeciesmostlybefoundinmountainousareasofJavaandwithhighpotentialasmedicinalandornamentalplant.However,researchonthisspeciesisstilllimited.Thisstudywasconductedtoinventory,describethemorphologicalcharacteristicsandtesttheseedviabilityofpacartereinfourresortsofBTSNP,namelyRPTNGunungPenanjakan,CobanTrisula,Senduro,andRanuDarungan.Surveymethodwasusedtoinventorytheplantpopulations.Directfieldobservationwasusedtocharacterizetheplantmorphology.Seedsviabilitytestwasconductedthroughgerminationonstrawpapermedia.TheresultsshowedthatpacarterepopulationswerefoundinthosefourBTSNPresorts,onshadeandhumidhabitats,alsoinopenareaswithwetsoilconditions.Theplantischaracterizedasanerectparennialherb,spursedpinkflower,capsulafruitwhichdehiscentwhenripe,withflattenedcone-shapedandsmoothhairyseeds.Seedgerminationtestshowedthattheseedsbegantogerminateonday5aftersowing(around20sprouts/day),epigealtype,withpercentageofgerminationandviabilitywas56%and90%respectively.ResultsofthisstudyareexpectedtoprovidebasicinformationtosupporttheconservationeffortsofI.platypetalabothin-situandex-situ(seedandlivingplant),alsoitspropagationeffortsforfurtherbioprospectingresearches
Wild bananas provide important genetic materials for further banana improvement, therefore they need to be conserved and studied. This study aimed to describe morphological characteristics of plant and seed and also to study the seed germination of wild banana M. acuminata var. flava (Ridl.) Nasution. The morphological characteristics were observed descriptively by referring to the descriptor for banana. The internal and external morphology of the seeds were observed using a digital microscope. The germination testing was carried out by a completely randomized design, using fresh seeds extracted from a bunch of fruits with two ripeness levels i.e. fully-ripe (yellow peel) and under-ripe (green-yellow peel). The data resulted was then analyzed using an independent t-test. The results showed that M. acuminata var. flava is characterized as a perennial herb; pseudostem height ≥3 m; male bud like a top with prominent green-yellow bracts; fruit curved and tasted mild-sweet when ripe. The seed is angular with wrinkled surface, and dark brown-black color when ripe. The longitudinal section showed parts of the seeds comprising the seed coat, outer and inner integument, embryo, endosperm, chalazal mass, micropyle cap and channel. The seeds are classified as orthodox, with hypogeal type and gradual germination pattern. The seeds extracted from fully-ripe fruit germinated faster with higher germination percentage and growth variables (root number and plant height). Thus, it is suggested to use physiologically mature seeds (seeds from fully-ripe fruits) which should be separated from the seeds of under-ripe fruits to lower the heterogeneity.
Ferns (Pteridophyta) is the oldest group of plants on earth that has more than 11.000 species. Ethnobotany and pharmacological studies have revealed that ferns contain potentially secondary metabolites as medicine. Purwodadi Botanic Gardens (Purwodadi BG) has fern collections that have not revealed information about drug potential. This research was conducted to inventory Purwodadi BG’s fern collections which have potential as medicine and to determine their conservation status. Inventory of fern collections is carried out by collecting data from the Registration Unit and observing directly in the field, while information about drug potential is obtained by literature review. A total of 31 species of 171 specimens of Purwodadi BG’s fern collections are known to be efficacious for treating various diseases, both traditional medicine, and research results. As many as 6 species of fern collections that have medicinal potential are included in IUCN Red List and categorized as least concern/LC and critically endangered/CR. The potential for medicinal plants of fern collections include anti-oxidants, anti-inflammatory, anti-microbial, anti-viral, and anti-cancer properties. This potential information is expected to increase the value of the fern’s function and their conservation efforts.
Adiantum spp. yang dikenal sebagai suplir merupakan tanaman hijau sepanjang tahun dan memiliki keragaman spesies yang tinggi yaitu lebih dari 200 spesies. Karakteristik Adiantum spp. terdapat pada daun majemuk dengan ukuran anak daun (pinnule) yang kecil dan bentuknya beragam dengan sori di bagian tepi abaksial daun, serta memiliki tangkai ental (stipe) berwarna hitam. Kebun Raya Purwodadi (KRP) memiliki koleksi lima spesies Adiantum spp., yaitu Adiantum caudatum, A. concinnum, A. cunninghamii, A. hispidulum, dan A. peruvianum. Penelitian ini bertujuan untuk mengkarakterisasi secara morfologi dan anatomi lima spesies Adiantum spp. koleksi KRP. Penelitian ini dilakukan pada bulan Oktober hingga November 2021 dengan mengamati dan men-deskripsikan karakter morfologi dan anatomi kelima spesies koleksi Adiantum spp. Analisis data dilakukan secara deskriptif kualitatif. Hasil penelitian menunjukkan bahwa kelimanya memiliki persamaan karakter pada permukaan tangkai ental, warna sisik, tipe indusium, bentuk spora, dan tipe stomata. Selain itu, terdapat pula karakter yang menjadi pembeda antar lima spesies Adiantum spp., yaitu ukuran tanaman, keberadaan sisik pada ental (frond), warna tangkai ental, tipe percabangan, panjang rakis, ukuran, bentuk, kedalaman toreh, jumlah, dan warna anak daun, bentuk dan susunan sel sisik, ukuran dan warna fiddlehead, jumlah dan ukuran spora, serta jumlah stomata. Hasil penelitian ini diharapkan dapat memberikan peran yang berharga untuk studi biologi serta dapat menjadi informasi dasar dalam melakukan identifikasi spesies tumbuhan paku.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.