To extend earlier observations of germline E‐cadherin mutations in kindreds with an inherited susceptibility to diffuse gastric cancer, we searched for germline E‐cadherin mutations in five further families affected predominantly by diffuse gastric cancer and one family with a history of diffuse gastric cancer and early‐onset breast cancer. Heterozygous inactivating mutations were found in the E‐cadherin gene in each of these families. No mutation hotspots were identified. These results demonstrate that germline mutation of the E‐cadherin gene is a common cause of hereditary diffuse gastric cancer and suggest a role for these mutations in the incidence of breast cancer. Hum Mutat 14:249–255, 1999. © 1999 Wiley‐Liss, Inc.

The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.

Increased VAT is an independent risk factor for CRN. Further large scale studies are needed to clarify the causal relationship between VAT and CRN.

Performance failure under pressure appears to be due to disruptions in attentional control once movement has been initiated. These findings support the predictions of attentional control theory and suggest that the QE may have an online control function, providing visual sensory information as the movement unfolds.

No abstract

Hepatitis B virus (HBV) infection is the major cause of chronic liver disease in Korea. This study investigated the seroprevalence of HBV infection with an emphasis on the coexistence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs). In all, 290,212 people undergoing health check-up examinations in 29 institutions during 2009 were recruited. The crude seroprevalences of HBsAg and anti-HBs was adjusted by age, sex, and geographic area using the 2009 estimated population of Korea. The adjusted seroprevalences of HBsAg and anti-HBs was 4.0% and 73.5%, respectively. Males showed higher HBsAg positivity and lower anti-HBs positivity than females (P<0.001). HBsAg positivity increased with age from 3.5% in people 20-29 years old to 4.8% in people 40-49 years old, followed by a decrease in people ≥ 50 years old. HBsAg positivity in Southern provinces (4.5%) including Jeju (5.9%), was significantly higher than that in Central provinces (3.6%; P<0.001). Interestingly, HBsAg and anti-HBs coexisted in 0.1% of the total subjects and in 2.9% of the HBsAg-positive group, showing distinct age distribution and higher alanine aminotransferase levels than those of the group positive for only HBsAg. In conclusion, the seroprevalence of HBsAg and anti-HBs in Korea varies significantly by age, sex and geographical location and coexisted in 2.9% of HBsAg-positive subjects. Continuous monitoring of seroepidemiology may facilitate the eventual eradication of HBV infection.

Colonoscopy is a useful modality for colorectal cancer screening in Korea, as established in Western countries. However, the screening colonoscopy may begin at an older age for Koreans than for Westerners. Similarly, the optimal starting age for screening in Korean women may be higher than that in men by 10 years.

Attendance at college sporting events generates billions of dollars annually for athletics departments at the college level in the United States. Based on Identity Theory and prior research, we developed and tested two models that were successful in predicting actual attendance, attendance intentions (conative loyalty), and support for the team across time. Respondents (N = 165; 60% female, 95% Caucasian) filled out three surveys across the year. In Model A (RMSEA = .066, x 2 /df = 50.02/29 = 1.73), prior season attendance, number of games intending to attend, and preseason team-fan role identity (Time 1) explained 63% of self-reported attendance behavior (Time 2). Those variables and postseason role identity (Time 2) explained 48.5% of attendance intentions (Time 3; Model A) and 43% of supporting the team in the future (Time 3; Model B, RMSEA = .060, x 2 /df = 46.16/29 = 1.59). Sports marketers need to take into account both the impact of role identity as a fan of the team and attendance intentions, not just prior attendance behavior, when predicting future attendance behavior and support for the team. n the United States, attendance for the NCAA (National Collegiate Athletic Association) football teams is fairly high across the Big 5 conferences, but not impressive in other divisions. Across all NCAA divisions, it seems to have plateaued at around 50 million fans per year (Trail & James, 2015). In the 2015 season, The Ohio State University averaged over 107,000 attendees per game (NCAA, 2016) and generated over $30 million (U.S.) from ticket sales for the season, showing how I