Visceral obesity as a risk factor for colorectal neoplasm

Oh, Tae Hoon; Byeon, Jeong‐Sik; Myung, Seung‐Jae; Yang, Suk-Kyun; Choi, Kyeong‐Hee; Chung, Jun‐Won; Kim, Benjamin; Lee, Don; Byun, Jae Ho; Jang, Se Jin; Kim, Jin-Ho

doi:10.1111/j.1440-1746.2007.05125.x

Cited by 89 publications

(73 citation statements)

References 35 publications

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“…Recent epidemiological studies have found that abdominal adiposity, in particular the presence of a large VAT compartment, is an important risk factor for cancer development and results in poor prognosis. [16][17][18][19][20] These findings suggest therefore that adipose tissue distribution may be an independent prognostic factor in patients treated curatively for localized prostate cancer. The prognostic significance of abdominal fat distribution in patients with prostate cancer treated with EBRT on Gleason score (GS), prostate-specific antigen (PSA) or clinical stage and outcomes, has not yet been studied.…”

Section: -14mentioning

confidence: 79%

Prognostic impact of abdominal adiposity, waist circumference and body mass index in patients with intermediate-risk prostate cancer treated with radiotherapy

Zilli

Nguyễn

et al. 2011

Int J Obes

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Objective: We tested the potential role of abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues, waist circumference (WC) and body mass index (BMI) as prognostic factors in patients with intermediate-risk prostate cancer (clinical stage T1b-2b, and Gleason Score (GS) ¼ 7 and prostate-specific antigen PSA level o15 ng ml À1 , or GS p6 and PSA between 10 and 20 ng ml À1 ) treated with ultrasound-based image-guided radiotherapy. Methods: VAT, SAT and WC (measured from planning abdominal computed tomography) and BMI were compared with clinical and pathologic factors using univariate analyses. Cox regression analyses were performed to evaluate whether obesity indices significantly predicted biochemical disease free-survival (bDFS). Results: Of the 112 eligible patients, 30 (27%) were obese. Median BMI at baseline was 27.5 kg m À2 (range, 19.2-51.5 kg m À2 ). Greater abdominal adiposity, WC and BMI were significantly associated with younger age at diagnosis and increased prostate volume (P ¼ 0.003 and P ¼ 0.002, respectively). No significant correlation between obesity measures and T-stage, GS, PSA or percentage of positive cores at biopsy was found. On Cox regression analyses, none of the obesity measures predicted for bDFS. No association was observed between obesity indices and surrogate markers of biochemical failure as PSA nadir (nPSA) or time to nPSA. Conclusions: Abdominal adiposity, WC and BMI are associated with younger age at diagnosis and greater prostate volume but not with an increased risk of biochemical failure in patients with intermediate-risk prostate cancer.

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Section: -14mentioning

confidence: 79%

Prognostic impact of abdominal adiposity, waist circumference and body mass index in patients with intermediate-risk prostate cancer treated with radiotherapy

Zilli

Nguyễn

et al. 2011

Int J Obes

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“…Betes et al [26] have proposed using BMI to stratify average-risk individuals for screening by colonoscopy, but their findings were limited by the lack of inclusion of important risk factors such as smoking in their study. In our study, we examined known risk factors, especially those that have been predictive of advanced neoplasia in asymptomatic Western [20][21][22]24] and Asian populations [34]. Driver et al [27] have demonstrated that BMI as well as age, smoking, and alcohol use were important factors in the development of a predictive model of colorectal cancer in men.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index as a Predictor of Colorectal Neoplasia in Ethnically Diverse Screening Population

et al. 2010

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“…Abdominal obesity, which is characterised as increased adipose tissue surrounding the intraabdominal organs, is also referred to as visceral or central obesity. It has been distinctly linked to several pathological conditions including impaired glucose and lipid metabolism, insulin resistance [7,8], increased predisposition to cancers of the colon [9], breast [10] and prostate [11], and it is associated with prolonged hospital stays, increased incidence of infections and non-infectious complications, and increased mortality in hospital [12]. Visceral obesity itself is an independent component of metabolic syndrome and the magnitude of obesity directly relates to the prognosis of this condition [7,13,14].…”

Section: Clinical Implications Of Obesitymentioning

confidence: 99%

The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis

Shuster¹,

Patlas²,

Pinthus³

et al. 2012

BJR

622

525

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ABSTRACT. As a result of the rising epidemic of obesity, understanding body fat distribution and its clinical implications is critical to timely treatment. Visceral adipose tissue is a hormonally active component of total body fat, which possesses unique biochemical characteristics that influence several normal and pathological processes in the human body. Abnormally high deposition of visceral adipose tissue is known as visceral obesity. This body composition phenotype is associated with medical disorders such as metabolic syndrome, cardiovascular disease and several malignancies including prostate, breast and colorectal cancers. Quantitative assessment of visceral obesity is important for evaluating the potential risk of development of these pathologies, as well as providing an accurate prognosis. This review aims to compare different methods of measuring visceral adiposity with emphasis on their advantages and drawbacks in clinical practice.

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Visceral obesity as a risk factor for colorectal neoplasm

Abstract: Increased VAT is an independent risk factor for CRN. Further large scale studies are needed to clarify the causal relationship between VAT and CRN.

Cited by 89 publications

References 35 publications

Prognostic impact of abdominal adiposity, waist circumference and body mass index in patients with intermediate-risk prostate cancer treated with radiotherapy

Prognostic impact of abdominal adiposity, waist circumference and body mass index in patients with intermediate-risk prostate cancer treated with radiotherapy

Body Mass Index as a Predictor of Colorectal Neoplasia in Ethnically Diverse Screening Population

The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis

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