Screening colonoscopy in asymptomatic average‐risk Koreans: Analysis in relation to age and sex

Choe, Jun-Ho; Chang, Hyo Won; Yang, Suk‐Kyun; Myung, Seung‐Jae; Byeon, Jeong‐Sik; Lee, Don; Song, Hebok; Lee, Hyun Ju; Chung, Eun-Ju; Kim, Sun Young; Jung, Hwoon‐Yong; Lee, Gin-Hyug; Hong, Weon‐Seon; Kim, Jin-Ho; Min, Young Il

doi:10.1111/j.1440-1746.2006.04774.x

Cited by 64 publications

(46 citation statements)

References 23 publications

(62 reference statements)

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“…In comparison with other studies, our results are lower than previous reports from developed countries among the asymptomatic average-risk subjects (Lieberman et al, 2000;Choe et al, 2007;Rundle et al, 2008;Siegel et al, 2012;Ng and Wong 2013;Yang et al, 2014). Heitman et al reported in their meta-analysis that the prevalence of non-advanced, advanced adenoma and cancer in North America were 17.7%, 5.7% and 0.3%, respectively (Heitman et al, 2009).…”

Section: Discussioncontrasting

confidence: 55%

“…Researchers from Asian-pacific developed countries have also reported a significant increase of CRC over the last decades. It seems that these countries actually have the same incidence as western countries; this could be due to the "westernization" of lifestyles in these countries (Choe et al, 2007;Chung et al, 2010;Aswakul et al, 2012;Ng and Wong 2013;Yang et al, 2014). This discrepancy between our findings and theirs might be related to lifestyle, diet, younger population and also genetic differences.…”

Section: Discussioncontrasting

confidence: 51%

“…It is expected that in an older age the prevalence of colorectal neoplasia would increase (Regula et al, 2006;Choe et al, 2007;Boursi et al, 2009;Corley et al, 2013). In our study, majority of the adenoma and advanced adenomas were found in subjects 50-59 years old followed by the 60-69 year old age group.…”

Section: Discussionmentioning

confidence: 50%

“…Therefore, some researchers have suggested considering gender as a factor for the time of initiation of colorectal screening. However, current guidelines do not recommend considering gender as a criteria for the initiation of screening (Choe et al, 2007;Corley et al, 2013). We could not indicate the appropriate age for the initiation of colorectal screening in men and women, separately.…”

Section: Discussionmentioning

confidence: 55%

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Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Sohrabi¹,

Zamani²,

Ajdarkosh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is one of the prime causes of mortality around the globe, with a significantly rising incidence in the Middle East region in recent decades. Since detection of CRC in the early stages is an important issue, and also since to date there are no comprehensive epidemiologic studies depicting the Middle East region with special attention to the average risk group, further investigation is of significant necessity in this regard. Aim: Our aim was to investigate the prevalence of preneoplastic and neoplastic lesions of the colon in an average risk population. Materials and Methods: A total of 1,208 eligible asymptomatic, average-risk adults older than 40 years of age, referred to Firuzgar Hospotal in the years 2008-2012, were enrolled. They underwent colonoscopy screening and all polypoid lesions were removed and examined by an expert gastrointestinal pathologist. The lesions were classified by size, location, numbers and pathologic findings. Size of lesions was measured objectively by endoscopists. Results: The mean age of participants was 56.5 ± 9.59 and 51.6% were male. The overall polyp detection rate was 199/1208 (16.5 %), 26 subjects having non-neoplastic polyps, including hyperplastic lesions, and 173/1208 (14.3%) having neoplastic polyps, of which 26 (2.15%) were advanced neoplasms .The prevalence of colorectal neoplasia was more common among the 50-59 age group. Advanced adenoma was more frequent among the 60-69 age group. The majority of adenomas were detected in the distal colon, but a quarter of advanced adenomas were found in the proximal colon; advance age and male gender was associated with the presence of adenoma. Conclusions: It seems that CRC screening among average-risk population might be recommended in countries such as Iran. However, sigmioidoscopy alone would miss many colorectal adenomas. Furthermore, the 50-59 age group could be considered as an appropriate target population for this purpose in Iran.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 55%

See 2 more Smart Citations

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Sohrabi¹,

Zamani²,

Ajdarkosh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Because cancer incidence tends to increase with age and CRC is more prevalent in males [20], the high incidence of CRC in elderly patients and males was not surprising. According to previous studies, male sex [6,21], age C50 years old [21], and smoking [6] were significantly associated with colorectal neoplasm (colorectal adenoma and cancer).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic features of gastric cancer with synchronous and metachronous colorectal cancer in Korea: are microsatellite instability and p53 overexpression useful markers for predicting colorectal cancer in gastric cancer patients?

Kim

Choi

et al. 2015

Gastric Cancer

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Background A large-scale study was performed to identify the risk factors for developing synchronous and metachronous colorectal cancer (CRC) in gastric cancer (GC) patients, including microsatellite instability (MSI) and p53 overexpression. Methods A total of 1041 GC patients who underwent endoscopic resection or surgery and underwent colonoscopy simultaneously or during surveillance for GC were consecutively enrolled. Clinicopathologic characteristics, MSI, and p53 overexpression were compared between the GC patients with and those without synchronous and metachronous CRC. Results Of the 1041 patients, CRCs were detected in 67 (6.4 %) patients with GC. Forty-six (4.4 %) had synchronous CRC and 21 (2.0 %) had metachronous CRC. Univariate analysis indicated that age C63 years (P \ 0.001), male sex (P = 0.005), and p53 overexpression (P = 0.040) were significantly associated with a higher incidence of CRC. However, body mass index, smoking, tumor location, tumor multiplicity, tumor histology, TNM stage, and MSI were not significantly associated with the incidence of CRC. Age C63 years (OR: 5.881; 95 % CI: 3.083-11.221; P \ 0.001) and male sex (OR: 2.933; 95 % CI: 1.307-6.584; P = 0.009) were risk factors for CRC in GC patients according to multivariate analysis. Conclusions GC patients who are male and/or C63 years old are recommended to receive colonoscopy to detect CRC. MSI and p53 overexpression were not useful molecular markers for predicting CRC in GC.

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Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee–Indiana Adenoma Recurrence Study

Washington

Ness

et al. 2016

Molecular Carcinogenesis

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It is unclear if proximal and distal traditional adenomas present with differences in molecular events which contribute to cancer heterogeneity by tumor anatomical subsite. Participants from a colonoscopy-based study (n=380) were divided into subgroups based on the location of their most advanced adenoma: proximal, distal, or “equivalent both sides”. Eight biomarkers in the most advanced adenomas were evaluated by immunohistochemistry (Ki-67, COX-2, TGFβRII, EGFR, β-catenin, cyclin D1, c-Myc) or TUNEL (apoptosis). After an adjustment for pathological features, there were no significant differences between proximal and distal adenomas for any biomarker. Conversely, expression levels did vary by other features, such as their size, villous component, and synchronousness. Large adenomas had higher expression levels of Ki-67(P<0.001), TGFβRII (P<0.0001), c-Myc (P<0.001), and cyclin D1 (P<0.001) in comparison to small adenomas, and tubulovillous/villous adenomas also were more likely to have similar higher expression levels in comparison to tubular adenomas. Adenoma location is not a major determinant of the expression of these biomarkers outside of other pathological features. This study suggests similarly important roles of Wnt/β-catenin and TGF-β pathways in carcinogenesis in both the proximal and distal colorectum.

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Screening colonoscopy in asymptomatic average‐risk Koreans: Analysis in relation to age and sex

Cited by 64 publications

References 23 publications

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Clinicopathologic features of gastric cancer with synchronous and metachronous colorectal cancer in Korea: are microsatellite instability and p53 overexpression useful markers for predicting colorectal cancer in gastric cancer patients?

Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee–Indiana Adenoma Recurrence Study

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